STRINGSTRING
SOS2 SOS2 SHC3 SHC3 KRAS KRAS LOC103079983 LOC103079983 CALML4 CALML4 SOS1 SOS1 CRH CRH GNG2 GNG2 PPP1CC PPP1CC HDAC11 HDAC11 LOC103070885 LOC103070885 LOC103072537 LOC103072537 DDC DDC GNAS GNAS MAP2K1 MAP2K1 LOC103076424 LOC103076424 MAPK1 MAPK1 LOC103071163 LOC103071163 CAMKK2 CAMKK2 CALML6 CALML6 GNB1 GNB1 ADCY5 ADCY5 LOC103070340 LOC103070340 LOC103071706 LOC103071706 ADORA2A ADORA2A LOC103071989 LOC103071989 LOC103073911 LOC103073911 GNAI3 GNAI3 LOC103085385 LOC103085385 GNG10 GNG10 PPP1CA PPP1CA GNG11 GNG11 LOC103074978 LOC103074978 HDAC2 HDAC2 ARAF ARAF HDAC6 HDAC6 ATF2 ATF2 CAMK4 CAMK4 LOC103081391 LOC103081391 ATF4 ATF4 HDAC10 HDAC10 LOC103076444 LOC103076444 MAPK3 MAPK3 GNG4 GNG4 LOC103080676 LOC103080676 GRIN2B GRIN2B LOC103074048 LOC103074048 SHC4 SHC4 GRIN2C GRIN2C GNG13 GNG13 CREB3 CREB3 LOC103084962 LOC103084962 CAMKK1 CAMKK1 LOC103090666 LOC103090666 PKIA PKIA HDAC5 HDAC5 GRB2 GRB2 SLC29A3 SLC29A3 LOC103083673 LOC103083673 MAOB MAOB CREB3L1 CREB3L1 GRIN3A GRIN3A LOC103090400 LOC103090400 SHC1 SHC1 SLC29A1 SLC29A1 MAOA MAOA LOC103086084 LOC103086084 LOC103071198 LOC103071198 PRKACB PRKACB GNG8 GNG8 FOSB FOSB HAT1 HAT1 CREB3L4 CREB3L4 GRIN3B GRIN3B CALM3 CALM3 ATF6B ATF6B GRIN1 GRIN1 LOC103079324 LOC103079324 SHC2 SHC2 GNB5 GNB5 CREB3L3 CREB3L3 ADORA2B ADORA2B GRIN2D GRIN2D LOC103082240 LOC103082240 RAF1 RAF1 SLC29A2 SLC29A2 GNG3 GNG3 NRAS NRAS LOC103079884 LOC103079884 LOC103081255 LOC103081255 GRIN2A GRIN2A HDAC7 HDAC7 LOC103080427 LOC103080427 LOC103081704 LOC103081704 LOC103081970 LOC103081970 LOC103069308 LOC103069308 DRD1 DRD1 TH TH LOC103089645 LOC103089645 CREB5 CREB5 NPY NPY PPP1R1B PPP1R1B LOC103075492 LOC103075492 LOC103089724 LOC103089724 GNAI1 GNAI1 PDYN PDYN CREB3L2 CREB3L2 LOC103070776 LOC103070776 HDAC8 HDAC8 LOC103074541 LOC103074541 CALML5 CALML5 HRAS HRAS GNAI2 GNAI2 LOC103069500 LOC103069500 BRAF BRAF GNB2 GNB2 GNB4 GNB4 PRKACA PRKACA HDAC1 HDAC1 LOC103069787 LOC103069787 GNB3 GNB3 SLC18A2 SLC18A2 HDAC3 HDAC3 LOC103068403 LOC103068403 LOC103068676 LOC103068676 HDAC4 HDAC4 LOC103076354 LOC103076354 LOC103077708 LOC103077708 LOC103079101 LOC103079101 LOC103080383 LOC103080383 CREB1 CREB1 LOC103082925 LOC103082925 LOC103086246 LOC103086246 LOC103088169 LOC103088169 LOC103076894 LOC103076894 LOC103078258 LOC103078258 LOC103080928 LOC103080928 LOC103086798 LOC103086798 SLC18A1 SLC18A1 LOC103074679 LOC103074679 LOC103076624 LOC103076624 LOC103080666 LOC103080666 LOC103081931 LOC103081931 LOC103083197 LOC103083197 LOC103088445 LOC103088445 LOC103081210 LOC103081210 LOC103087068 LOC103087068 LOC103089763 LOC103089763 PPP1CB PPP1CB LOC103077443 LOC103077443 CALM1 CALM1 LOC103078828 LOC103078828 LOC103085965 LOC103085965 SLC6A3 SLC6A3 BDNF BDNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOS2Son of sevenless homolog 2-like. (1272 aa)
SHC3SHC-transforming protein 3. (588 aa)
KRASGTPase KRas. (188 aa)
LOC103079983Histone H2A; Belongs to the histone H2A family. (128 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
CRHCorticoliberin. (193 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
HDAC11Histone deacetylase 11. (266 aa)
LOC103070885Histone H2A; Belongs to the histone H2A family. (128 aa)
LOC103072537Histone H2A; Belongs to the histone H2A family. (130 aa)
DDCaromatic-L-amino-acid decarboxylase. (315 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (991 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
LOC103076424Histone H3.3-like. (136 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
LOC103071163Histone H2B; Belongs to the histone H2B family. (126 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X1. (580 aa)
CALML6Calmodulin-like protein 6. (190 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1. (340 aa)
ADCY5Adenylate cyclase type 5 isoform X1. (1263 aa)
LOC103070340Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103071706Histone H2A; Belongs to the histone H2A family. (130 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (408 aa)
LOC103071989Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103073911Histone H2B; Belongs to the histone H2B family. (126 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
LOC103085385Neuroendocrine secretory protein 55-like. (242 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
LOC103074978Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X2. (609 aa)
HDAC6Histone deacetylase 6. (1142 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (473 aa)
LOC103081391Histone H3.3-like. (172 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
HDAC10Histone deacetylase 10. (668 aa)
LOC103076444Histone H3; Belongs to the histone H3 family. (136 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC103080676Histone H2A; Belongs to the histone H2A family. (129 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B. (1496 aa)
LOC103074048Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (134 aa)
SHC4SHC-transforming protein 4 isoform X1. (631 aa)
GRIN2CGlutamate receptor ionotropic, NMDA 2C. (1201 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X1. (376 aa)
LOC103084962Histone H2A; Belongs to the histone H2A family. (143 aa)
CAMKK1Calcium/calmodulin-dependent protein kinase kinase 1. (505 aa)
LOC103090666Histone H2A; Belongs to the histone H2A family. (130 aa)
PKIAcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (92 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1127 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
SLC29A3Equilibrative nucleoside transporter 3. (474 aa)
LOC103083673Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (379 aa)
MAOBAmine oxidase. (520 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
GRIN3AGlutamate receptor ionotropic, NMDA 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1115 aa)
LOC103090400Histone H2B; Belongs to the histone H2B family. (126 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
SLC29A1Equilibrative nucleoside transporter 1. (456 aa)
MAOAAmine oxidase. (527 aa)
LOC103086084LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit B-like. (375 aa)
LOC103071198Histone H2A; Belongs to the histone H2A family. (144 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta. (274 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (80 aa)
FOSBProtein fosB isoform X1. (341 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (426 aa)
GRIN3BGlutamate receptor ionotropic, NMDA 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1035 aa)
CALM3Calmodulin isoform X2; Belongs to the calmodulin family. (149 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X1. (709 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1 isoform X1. (959 aa)
LOC103079324Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
SHC2SHC-transforming protein 2. (801 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5 isoform X1. (395 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2. (458 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (333 aa)
GRIN2DGlutamate receptor ionotropic, NMDA 2D. (1334 aa)
LOC103082240Histone H2A; Belongs to the histone H2A family. (130 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
SLC29A2Equilibrative nucleoside transporter 2. (456 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
NRASGTPase NRas. (189 aa)
LOC103079884Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC103081255Histone H2B; Belongs to the histone H2B family. (142 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A. (1464 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (946 aa)
LOC103080427Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103081704Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103081970Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC103069308Uncharacterized protein LOC103069308. (439 aa)
DRD1D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (446 aa)
THTyrosine 3-monooxygenase. (492 aa)
LOC103089645Histone H2A; Belongs to the histone H2A family. (128 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
NPYPro-neuropeptide Y. (97 aa)
PPP1R1BProtein phosphatase 1 regulatory subunit 1B. (202 aa)
LOC103075492Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LOC103089724Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
PDYNproenkephalin-B. (252 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
LOC103070776Histone H3-like centromeric protein CSE4-like. (277 aa)
HDAC8Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (415 aa)
LOC103074541LOW QUALITY PROTEIN: calmodulin-like protein 1-like; Belongs to the calmodulin family. (289 aa)
CALML5Calmodulin-like protein 5. (140 aa)
HRASGTPase HRas isoform X1. (189 aa)
GNAI2LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I) subunit alpha-2. (360 aa)
LOC103069500Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (76 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (538 aa)
LOC103069787BDNF/NT-3 growth factors receptor-like isoform X1. (553 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
SLC18A2Synaptic vesicular amine transporter. (517 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
LOC103068403Histone H2B type W-T-like; Belongs to the histone H2B family. (184 aa)
LOC103068676Histone H2B type W-T-like; Belongs to the histone H2B family. (177 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1148 aa)
LOC103076354Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC103077708Histone H3; Belongs to the histone H3 family. (136 aa)
LOC103079101Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103080383Histone H3; Belongs to the histone H3 family. (119 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (293 aa)
LOC103082925Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103086246Histone H2A; Belongs to the histone H2A family. (131 aa)
LOC103088169Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC103076894Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103078258Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103080928Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC103086798Histone H2B; Belongs to the histone H2B family. (126 aa)
SLC18A1Chromaffin granule amine transporter. (523 aa)
LOC103074679Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC103076624Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103080666Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103081931Histone H3; Belongs to the histone H3 family. (150 aa)
LOC103083197Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC103088445Histone H2A; Belongs to the histone H2A family. (117 aa)
LOC103081210Histone H3.1-like isoform X1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (332 aa)
LOC103087068Histone H2A; Belongs to the histone H2A family. (128 aa)
LOC103089763Uncharacterized protein LOC103089763. (411 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
LOC103077443Histone H2A; Belongs to the histone H2A family. (130 aa)
CALM1Calmodulin isoform X1; Belongs to the calmodulin family. (150 aa)
LOC103078828Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC103085965Histone H2B; Belongs to the histone H2B family. (126 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (248 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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