STRINGSTRING
RHOA RHOA MAPK8 MAPK8 IL1B IL1B LOC103071783 LOC103071783 CALML4 CALML4 IL1A IL1A IL6 IL6 MAPK1 MAPK1 CALML6 CALML6 GNAI3 GNAI3 TICAM2 TICAM2 TLR4 TLR4 LOC103086436 LOC103086436 NOS2 NOS2 LOC103088795 LOC103088795 PYCARD PYCARD C5 C5 MAPK11 MAPK11 MAPK3 MAPK3 ITGAM ITGAM ITGB2 ITGB2 IL12A IL12A LY96 LY96 MAPK12 MAPK12 LOC103072956 LOC103072956 SERPING1 SERPING1 IRAK1 IRAK1 C1QA C1QA C1QB C1QB C1QC C1QC CALM3 CALM3 C2 C2 TNF TNF FOS FOS LOC103070643 LOC103070643 C4A C4A LOC103078860 LOC103078860 RELA RELA IRAK4 IRAK4 JUN JUN TICAM1 TICAM1 CD14 CD14 MYD88 MYD88 C3 C3 CFL1 CFL1 LOC103070856 LOC103070856 LOC103081962 LOC103081962 IRF3 IRF3 IRF1 IRF1 MAPK9 MAPK9 TIRAP TIRAP MAPK10 MAPK10 NFKB1 NFKB1 CFL2 CFL2 NOD1 NOD1 LOC103087851 LOC103087851 LOC103073993 LOC103073993 IL12B IL12B MAPK14 MAPK14 GNAI1 GNAI1 MAPK13 MAPK13 LOC103076856 LOC103076856 LOC103082093 LOC103082093 LOC103074541 LOC103074541 CALML5 CALML5 GNAI2 GNAI2 IRF8 IRF8 CASP3 CASP3 ITGA5 ITGA5 IL23A IL23A IL8 IL8 CASP7 CASP7 C1R C1R LOC103087891 LOC103087891 C1S C1S C4BPB C4BPB IL10 IL10 CALM1 CALM1 ITGB1 ITGB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHOATransforming protein RhoA isoform X1. (221 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
LOC103071783Probable transcriptional regulator ycf29-like. (170 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
IL6LOW QUALITY PROTEIN: interleukin-6. (243 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
CALML6Calmodulin-like protein 6. (190 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
TICAM2TIR domain-containing adapter molecule 2. (235 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
LOC103086436Probable transcriptional regulator ycf29-like. (210 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
LOC103088795TNF receptor-associated factor 6-like. (315 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (195 aa)
C5LOW QUALITY PROTEIN: complement C5. (1677 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (1152 aa)
ITGB2Integrin beta. (769 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (257 aa)
LY96Lymphocyte antigen 96. (160 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
LOC103072956Uncharacterized protein LOC103072956. (225 aa)
SERPING1Plasma protease C1 inhibitor; Belongs to the serpin family. (483 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (732 aa)
C1QAComplement C1q subcomponent subunit A. (245 aa)
C1QBComplement C1q subcomponent subunit B. (252 aa)
C1QCComplement C1q subcomponent subunit C. (245 aa)
CALM3Calmodulin isoform X2; Belongs to the calmodulin family. (149 aa)
C2Complement C2 isoform X1; Belongs to the peptidase S1 family. (751 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
LOC103070643Probable transcriptional regulator ycf29-like. (212 aa)
C4AComplement C4-A. (1739 aa)
LOC103078860Caspase-1-like; Belongs to the peptidase C14A family. (404 aa)
RELATranscription factor p65 isoform X1. (560 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (337 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (701 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
C3Complement C3. (1660 aa)
CFL1Cofilin-1; Belongs to the actin-binding proteins ADF family. (166 aa)
LOC103070856C-X-C motif chemokine. (113 aa)
LOC103081962NACHT, LRR and PYD domains-containing protein 3-like. (1037 aa)
IRF3Interferon regulatory factor 3 isoform X1. (420 aa)
IRF1Interferon regulatory factor. (322 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein. (228 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
CFL2Cofilin-2 isoform X1; Belongs to the actin-binding proteins ADF family. (166 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
LOC103087851Pulmonary surfactant-associated protein A-like isoform X1. (248 aa)
LOC103073993Apoptosis-associated speck-like protein containing a CARD-like. (258 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
LOC103076856Cofilin-1-like; Belongs to the actin-binding proteins ADF family. (262 aa)
LOC103082093Probable transcriptional regulator ycf29-like. (205 aa)
LOC103074541LOW QUALITY PROTEIN: calmodulin-like protein 1-like; Belongs to the calmodulin family. (289 aa)
CALML5Calmodulin-like protein 5. (140 aa)
GNAI2LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I) subunit alpha-2. (360 aa)
IRF8Interferon regulatory factor 8. (426 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (275 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1053 aa)
IL23AInterleukin-23 subunit alpha. (187 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CASP7Caspase-7 isoform X1; Belongs to the peptidase C14A family. (301 aa)
C1RComplement C1r subcomponent; Belongs to the peptidase S1 family. (713 aa)
LOC103087891C4b-binding protein alpha chain-like. (665 aa)
C1SLOW QUALITY PROTEIN: complement C1s subcomponent; Belongs to the peptidase S1 family. (793 aa)
C4BPBC4b-binding protein beta chain. (198 aa)
IL10Interleukin-10. (178 aa)
CALM1Calmodulin isoform X1; Belongs to the calmodulin family. (150 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (805 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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