STRINGSTRING
RPS6KA2 RPS6KA2 RHOA RHOA MAPK8 MAPK8 IL1B IL1B ARF6 ARF6 SRC SRC LCP2 LCP2 ACTB ACTB ELMO1 ELMO1 NFATC2 NFATC2 PXN PXN ELMO2 ELMO2 TBK1 TBK1 IL6 IL6 LOC103081641 LOC103081641 NFATC1 NFATC1 VAV3 VAV3 MAP2K3 MAP2K3 GSK3B GSK3B MAP2K1 MAP2K1 GIT2 GIT2 RAC1 RAC1 WAS WAS MAPK1 MAPK1 LOC103082455 LOC103082455 NLRC4 NLRC4 CRKL CRKL WIPF1 WIPF1 TLR4 TLR4 PIK3R3 PIK3R3 ARHGEF12 ARHGEF12 LOC103088795 LOC103088795 VAV2 VAV2 PYCARD PYCARD PIK3CD PIK3CD DOCK1 DOCK1 MEFV MEFV MAPK11 MAPK11 TAB1 TAB1 MAP3K7 MAP3K7 MAPK3 MAPK3 CRK CRK LAT LAT ARHGEF7 ARHGEF7 IKBKB IKBKB RPS6KA6 RPS6KA6 MAPK12 MAPK12 RAC2 RAC2 LOC103075361 LOC103075361 PIK3R1 PIK3R1 AKT1 AKT1 LOC103073772 LOC103073772 MAP2K4 MAP2K4 LOC103072956 LOC103072956 LOC103075075 LOC103075075 CCL2 CCL2 ARHGEF1 ARHGEF1 AKT2 AKT2 IKBKG IKBKG FN1 FN1 IRAK1 IRAK1 RPS6KA1 RPS6KA1 ROCK2 ROCK2 ARHGEF28 ARHGEF28 GNAQ GNAQ TAB2 TAB2 PIP5K1A PIP5K1A PIP5K1C PIP5K1C MAP2K7 MAP2K7 TNF TNF FOS FOS TRAF2 TRAF2 WASF2 WASF2 CDC42 CDC42 MAP2K2 MAP2K2 LOC103078860 LOC103078860 RELA RELA PIK3R2 PIK3R2 ACTG1 ACTG1 BAIAP2 BAIAP2 IRAK4 IRAK4 JUN JUN AKT3 AKT3 TICAM1 TICAM1 MYD88 MYD88 VAV1 VAV1 FYB FYB LOC103081962 LOC103081962 IRF3 IRF3 ITGA4 ITGA4 BCAR1 BCAR1 RAC3 RAC3 IL18 IL18 PLCG1 PLCG1 NFKBIA NFKBIA IL2 IL2 RHOG RHOG WIPF2 WIPF2 MAPK9 MAPK9 MAPK10 MAPK10 NFKB1 NFKB1 LOC103069126 LOC103069126 LOC103073993 LOC103073993 ACTR2 ACTR2 PTK2B PTK2B PIK3CB PIK3CB PTK2 PTK2 PIP5K1B PIP5K1B PIK3CA PIK3CA MAPK14 MAPK14 MAPK13 MAPK13 CD8A CD8A WIPF3 WIPF3 SKAP2 SKAP2 LIMK1 LIMK1 CD8B CD8B ITGA5 ITGA5 RPS6KA3 RPS6KA3 IL8 IL8 CD4 CD4 PKN2 PKN2 PKN1 PKN1 LCK LCK ZAP70 ZAP70 CHUK CHUK ACTR3B ACTR3B LOC103083466 LOC103083466 IL10 IL10 WASL WASL ITGB1 ITGB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
RHOATransforming protein RhoA isoform X1. (221 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
SRCTyrosine-protein kinase. (548 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
ACTBActin, cytoplasmic 1. (375 aa)
ELMO1Engulfment and cell motility protein 1 isoform X1. (742 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (919 aa)
PXNPaxillin-like isoform X1; Belongs to the paxillin family. (591 aa)
ELMO2Engulfment and cell motility protein 2 isoform X3. (732 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (753 aa)
IL6LOW QUALITY PROTEIN: interleukin-6. (243 aa)
LOC103081641LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6-like; Belongs to the protein kinase superfamily. (394 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (697 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X1. (875 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
GIT2ARF GTPase-activating protein GIT2 isoform X1. (758 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (201 aa)
WASwiskott-Aldrich syndrome protein. (502 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
LOC103082455Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
NLRC4NLR family CARD domain-containing protein 4. (1024 aa)
CRKLCrk-like protein. (303 aa)
WIPF1WAS/WASL-interacting protein family member 1-like. (495 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
ARHGEF12LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 12. (1563 aa)
LOC103088795TNF receptor-associated factor 6-like. (315 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (878 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (195 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
DOCK1Dedicator of cytokinesis protein 1; Belongs to the DOCK family. (1886 aa)
MEFVPyrin. (668 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (504 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
LATLinker for activation of T-cells family member 1. (260 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7 isoform X2. (803 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
RPS6KA6Ribosomal protein S6 kinase. (747 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
LOC103075361Putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like. (149 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC103073772Interferon beta-2-like. (186 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (410 aa)
LOC103072956Uncharacterized protein LOC103072956. (225 aa)
LOC103075075Putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like. (149 aa)
CCL2C-C motif chemokine. (99 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1 isoform X1. (913 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (419 aa)
FN1LOW QUALITY PROTEIN: fibronectin. (2483 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (732 aa)
RPS6KA1Ribosomal protein S6 kinase. (742 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1389 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1390 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (549 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma. (828 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
WASF2wiskott-Aldrich syndrome protein family member 2 isoform X1. (498 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
LOC103078860Caspase-1-like; Belongs to the peptidase C14A family. (404 aa)
RELATranscription factor p65 isoform X1. (560 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1. (535 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (337 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (701 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
VAV1Proto-oncogene vav isoform X1. (844 aa)
FYBFYN-binding protein-like isoform X1. (836 aa)
LOC103081962NACHT, LRR and PYD domains-containing protein 3-like. (1037 aa)
IRF3Interferon regulatory factor 3 isoform X1. (420 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (1033 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X1. (867 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (192 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
NFKBIANF-kappa-B inhibitor alpha. (304 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
RHOGRho-related GTP-binding protein RhoG. (191 aa)
WIPF2WAS/WASL-interacting protein family member 2 isoform X1. (440 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
LOC103069126Actin-related protein 3-like isoform X1; Belongs to the actin family. (418 aa)
LOC103073993Apoptosis-associated speck-like protein containing a CARD-like. (258 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PTK2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1003 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1. (540 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CD8AT-cell surface glycoprotein CD8 alpha chain. (239 aa)
WIPF3WAS/WASL-interacting protein family member 3. (416 aa)
SKAP2Src kinase-associated phosphoprotein 2. (357 aa)
LIMK1LIM domain kinase 1. (647 aa)
CD8BT-cell surface glycoprotein CD8 beta chain isoform X1. (210 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1053 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CD4T-cell surface glycoprotein CD4. (454 aa)
PKN2Serine/threonine-protein kinase N2 isoform X1. (983 aa)
PKN1Serine/threonine-protein kinase N1 isoform X2. (950 aa)
LCKTyrosine-protein kinase. (520 aa)
ZAP70Tyrosine-protein kinase. (635 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (747 aa)
ACTR3BActin-related protein 3B-like isoform X1; Belongs to the actin family. (418 aa)
LOC103083466Rho-related GTP-binding protein RhoG-like. (191 aa)
IL10Interleukin-10. (178 aa)
WASLNeural Wiskott-Aldrich syndrome protein. (505 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (805 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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