STRINGSTRING
LAMB2 LAMB2 IL1B IL1B RAB5C RAB5C ADCY1 ADCY1 LAMA3 LAMA3 IL6 IL6 GNAS GNAS PRKCB PRKCB LAMC1 LAMC1 LOC103069249 LOC103069249 ARG2 ARG2 LOC103085385 LOC103085385 LAMC2 LAMC2 PLCB4 PLCB4 TLR4 TLR4 PRDX1 PRDX1 PLCB1 PLCB1 PIK3R3 PIK3R3 NOS2 NOS2 LAMA2 LAMA2 LAMC3 LAMC3 PIK3CD PIK3CD LAMB3 LAMB3 SERPINB6 SERPINB6 ACTN1 ACTN1 ITGAM ITGAM ITGB2 ITGB2 LAMA4 LAMA4 LOC103084028 LOC103084028 PRKCA PRKCA COL4A1 COL4A1 LAMB4 LAMB4 IL12A IL12A LOC103075361 LOC103075361 COL4A2 COL4A2 PIK3R1 PIK3R1 LAMB1 LAMB1 LOC103075075 LOC103075075 ARG1 ARG1 FN1 FN1 LOC103069948 LOC103069948 C8G C8G LOC103069096 LOC103069096 LOC103090225 LOC103090225 PRKACB PRKACB TGFB3 TGFB3 GNAQ GNAQ GNA11 GNA11 LAMA1 LAMA1 TNF TNF TGFB1 TGFB1 PRKCG PRKCG C9 C9 PLCB2 PLCB2 GNA15 GNA15 RELA RELA GNA14 GNA14 PLCB3 PLCB3 PIK3R2 PIK3R2 C8A C8A CD14 CD14 GNAL GNAL LOC103071959 LOC103071959 IFNG IFNG CSF2 CSF2 C8B C8B SERPINB10 SERPINB10 LAMA5 LAMA5 COL4A6 COL4A6 LOC103071404 LOC103071404 LOC103071675 LOC103071675 COL4A5 COL4A5 NFKB1 NFKB1 LOC103071971 LOC103071971 PIK3CB PIK3CB IL12B IL12B LOC103090179 LOC103090179 PTK2 PTK2 PIK3CA PIK3CA COL3A1 COL3A1 RAB7A RAB7A COL4A4 COL4A4 MUC2 MUC2 RAB5B RAB5B CASP3 CASP3 PRKACA PRKACA VCL VCL IL8 IL8 COL4A3 COL4A3 HSPB1 HSPB1 ACTN4 ACTN4 RAB7B RAB7B IL10 IL10 TGFB2 TGFB2 RAB5A RAB5A CTSG CTSG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LAMB2Laminin subunit beta-2. (1801 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
RAB5CRas-related protein Rab-5C. (216 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1134 aa)
LAMA3Laminin subunit alpha-3. (3338 aa)
IL6LOW QUALITY PROTEIN: interleukin-6. (243 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (991 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
LAMC1LOW QUALITY PROTEIN: laminin subunit gamma-1. (1618 aa)
LOC103069249Collagen alpha-2(I) chain-like isoform X3. (1370 aa)
ARG2Arginase. (354 aa)
LOC103085385Neuroendocrine secretory protein 55-like. (242 aa)
LAMC2Laminin subunit gamma-2. (1191 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
PRDX1Peroxiredoxin-1 isoform X1. (224 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
LAMA2Laminin subunit alpha-2 isoform X1. (3125 aa)
LAMC3Laminin subunit gamma-3. (1577 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
LAMB3Laminin subunit beta-3. (1172 aa)
SERPINB6Serpin B6; Belongs to the serpin family. (373 aa)
ACTN1Alpha-actinin-1 isoform X1. (914 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (1152 aa)
ITGB2Integrin beta. (769 aa)
LAMA4Laminin subunit alpha-4 isoform X2. (1823 aa)
LOC103084028LOW QUALITY PROTEIN: interleukin-1 receptor type 1-like. (592 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
COL4A1Collagen alpha-1(IV) chain. (1668 aa)
LAMB4LOW QUALITY PROTEIN: laminin subunit beta-4. (1740 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (257 aa)
LOC103075361Putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like. (149 aa)
COL4A2Collagen alpha-2(IV) chain. (1671 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
LAMB1Laminin subunit beta-1. (1786 aa)
LOC103075075Putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like. (149 aa)
ARG1Arginase. (322 aa)
FN1LOW QUALITY PROTEIN: fibronectin. (2483 aa)
LOC103069948LOW QUALITY PROTEIN: interleukin-1 receptor type 2-like. (450 aa)
C8GComplement component C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (320 aa)
LOC103069096T-cell surface glycoprotein CD1b-1-like. (333 aa)
LOC103090225Cathepsin G-like; Belongs to the peptidase S1 family. (250 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta. (274 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
LAMA1Laminin subunit alpha-1. (3063 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
C9Complement component C9. (548 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1420 aa)
GNA15Guanine nucleotide-binding protein subunit alpha-15. (374 aa)
RELATranscription factor p65 isoform X1. (560 aa)
GNA14Guanine nucleotide-binding protein subunit alpha-14. (355 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
C8AComplement component C8 alpha chain. (589 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
GNALGuanine nucleotide-binding protein G(Olf) subunit alpha isoform X1. (380 aa)
LOC103071959C-X-C motif chemokine. (100 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
C8BComplement component C8 beta chain. (586 aa)
SERPINB10Serpin B10; Belongs to the serpin family. (398 aa)
LAMA5Laminin subunit alpha-5. (3689 aa)
COL4A6Collagen alpha-6(IV) chain. (1688 aa)
LOC103071404C-X-C motif chemokine. (227 aa)
LOC103071675C-X-C motif chemokine. (196 aa)
COL4A5Collagen alpha-5(IV) chain isoform X2. (1694 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
LOC103071971Collagen alpha-1(I) chain-like. (1463 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
LOC103090179Toll-like receptor 2-like isoform X1; Belongs to the Toll-like receptor family. (785 aa)
PTK2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1003 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
COL3A1Collagen alpha-1(III) chain-like. (1462 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
COL4A4Collagen alpha-4(IV) chain. (1686 aa)
MUC2Mucin-2. (3417 aa)
RAB5BRas-related protein Rab-5B isoform X1. (215 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (275 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
VCLVinculin isoform X1. (1134 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
COL4A3Collagen alpha-3(IV) chain. (1681 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
ACTN4Alpha-actinin-4 isoform X1. (933 aa)
RAB7BRas-related protein Rab-7b. (200 aa)
IL10Interleukin-10. (178 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (250 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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