STRINGSTRING
MAPK8 MAPK8 SOS2 SOS2 KRAS KRAS IFNAR1 IFNAR1 SRC SRC E2F1 E2F1 NFATC4 NFATC4 STAT5B STAT5B SOS1 SOS1 NFATC2 NFATC2 FASLG FASLG EGR2 EGR2 SMAD3 SMAD3 STAT5A STAT5A STAT3 STAT3 TBK1 TBK1 IL6 IL6 LOC103081641 LOC103081641 NFATC1 NFATC1 LOC103079638 LOC103079638 MAP2K3 MAP2K3 MAP2K1 MAP2K1 LOC103069156 LOC103069156 PRKCB PRKCB MAPK1 MAPK1 TICAM2 TICAM2 TLR4 TLR4 MMP9 MMP9 ARAF ARAF PIK3R3 PIK3R3 PCNA PCNA JAK2 JAK2 ATF2 ATF2 EGR3 EGR3 LOC103088795 LOC103088795 MAP3K1 MAP3K1 ELK1 ELK1 PIK3CD PIK3CD CREBBP CREBBP ATF4 ATF4 MAPK11 MAPK11 EP300 EP300 TAB1 TAB1 MAP3K7 MAP3K7 SLC10A1 SLC10A1 MAPK3 MAPK3 LOC103090661 LOC103090661 CCNE2 CCNE2 MAVS MAVS LOC103069739 LOC103069739 PRKCA PRKCA IKBKB IKBKB DDB2 DDB2 CREB3 CREB3 MAPK12 MAPK12 LOC103068617 LOC103068617 GRB2 GRB2 YWHAQ YWHAQ PIK3R1 PIK3R1 E2F3 E2F3 AKT1 AKT1 LOC103091202 LOC103091202 LOC103069181 LOC103069181 LOC103073219 LOC103073219 CREB3L1 CREB3L1 LOC103073772 LOC103073772 MAP2K4 MAP2K4 MYC MYC ATP6AP1 ATP6AP1 LOC103072956 LOC103072956 TRAF3 TRAF3 VDAC3 VDAC3 TGFBR2 TGFBR2 DDX3X DDX3X AKT2 AKT2 IKBKG IKBKG IRAK1 IRAK1 TP53 TP53 CASP9 CASP9 TGFB3 TGFB3 TAB2 TAB2 CREB3L4 CREB3L4 E2F2 E2F2 MAP2K7 MAP2K7 HSPG2 HSPG2 ATF6B ATF6B TNF TNF TGFB1 TGFB1 FOS FOS PRKCG PRKCG TGFBR1 TGFBR1 MAP2K2 MAP2K2 RELA RELA DDB1 DDB1 JAK3 JAK3 PIK3R2 PIK3R2 IRAK4 IRAK4 JAK1 JAK1 JUN JUN CREB3L3 CREB3L3 AKT3 AKT3 TICAM1 TICAM1 MYD88 MYD88 TYK2 TYK2 IRF3 IRF3 BAX BAX BIRC5 BIRC5 RAF1 RAF1 LOC103079424 LOC103079424 BAD BAD NRAS NRAS CCNA2 CCNA2 BCL2 BCL2 NFKBIA NFKBIA STAT4 STAT4 MAPK9 MAPK9 TIRAP TIRAP SMAD4 SMAD4 MAPK10 MAPK10 NFKB1 NFKB1 YWHAB YWHAB YWHAZ YWHAZ FADD FADD LOC103069117 LOC103069117 CREB5 CREB5 LOC103075495 LOC103075495 PTK2B PTK2B CCNA1 CCNA1 TLR3 TLR3 PIK3CB PIK3CB IFIH1 IFIH1 LOC103090179 LOC103090179 PIK3CA PIK3CA MAPK14 MAPK14 MAPK13 MAPK13 CREB3L2 CREB3L2 HRAS HRAS IRF7 IRF7 RB1 RB1 LOC103083173 LOC103083173 CASP3 CASP3 BRAF BRAF CASP8 CASP8 LOC103074001 LOC103074001 APAF1 APAF1 CDKN1A CDKN1A IL8 IL8 STAT6 STAT6 STAT2 STAT2 CDK2 CDK2 BID BID FAS FAS CCNE1 CCNE1 CREB1 CREB1 CASP10 CASP10 CHUK CHUK TGFB2 TGFB2 IKBKE IKBKE DDX58 DDX58
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK8Mitogen-activated protein kinase. (427 aa)
SOS2Son of sevenless homolog 2-like. (1272 aa)
KRASGTPase KRas. (188 aa)
IFNAR1Interferon alpha/beta receptor 1. (562 aa)
SRCTyrosine-protein kinase. (548 aa)
E2F1Transcription factor E2F1. (437 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (901 aa)
STAT5BSignal transducer and activator of transcription. (792 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (919 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (485 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT3Signal transducer and activator of transcription. (654 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (753 aa)
IL6LOW QUALITY PROTEIN: interleukin-6. (243 aa)
LOC103081641LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6-like; Belongs to the protein kinase superfamily. (394 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (697 aa)
LOC103079638Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (173 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
LOC103069156Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
TICAM2TIR domain-containing adapter molecule 2. (235 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
MMP9Matrix metalloproteinase-9. (708 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X2. (609 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
EGR3Early growth response protein 3 isoform X1. (387 aa)
LOC103088795TNF receptor-associated factor 6-like. (315 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1926 aa)
ELK1ETS domain-containing protein Elk-1 isoform X1. (444 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
CREBBPCREB-binding protein isoform X1. (2429 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
EP300Histone acetyltransferase p300. (2420 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (504 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
SLC10A1Sodium/bile acid cotransporter. (349 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
LOC103090661Interferon alpha-1-like. (189 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
MAVSMitochondrial antiviral-signaling protein. (514 aa)
LOC103069739Interferon alpha-1-like. (189 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
DDB2DNA damage-binding protein 2 isoform X1. (463 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X1. (376 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
LOC103068617Interferon alpha-1-like. (188 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
E2F3Transcription factor E2F3. (469 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC103091202Interferon alpha-1-like. (188 aa)
LOC103069181Interferon alpha-1-like. (189 aa)
LOC103073219LOW QUALITY PROTEIN: interferon alpha-8-like. (248 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
LOC103073772Interferon beta-2-like. (186 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (410 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa)
ATP6AP1V-type proton ATPase subunit S1. (469 aa)
LOC103072956Uncharacterized protein LOC103072956. (225 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
VDAC3Voltage-dependent anion-selective channel protein 3 isoform X1. (284 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
DDX3XATP-dependent RNA helicase DDX3X-like isoform X1; Belongs to the DEAD box helicase family. (662 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (419 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (732 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (452 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (426 aa)
E2F2Transcription factor E2F2. (439 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
HSPG2Basement membrane-specific heparan sulfate proteoglycan core protein. (4406 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X1. (709 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
RELATranscription factor p65 isoform X1. (560 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (337 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2. (458 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (701 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
TYK2Tyrosine-protein kinase. (1186 aa)
IRF3Interferon regulatory factor 3 isoform X1. (420 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
LOC103079424LOW QUALITY PROTEIN: caspase-12-like; Belongs to the peptidase C14A family. (446 aa)
BADBcl2 antagonist of cell death. (168 aa)
NRASGTPase NRas. (189 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (432 aa)
BCL2Apoptosis regulator Bcl-2. (232 aa)
NFKBIANF-kappa-B inhibitor alpha. (304 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein. (228 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (246 aa)
YWHAZ14-3-3 protein zeta/delta isoform X1; Belongs to the 14-3-3 family. (245 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
LOC103069117LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-like. (721 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (508 aa)
LOC103075495Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (421 aa)
TLR3LOW QUALITY PROTEIN: toll-like receptor 3; Belongs to the Toll-like receptor family. (956 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
IFIH1Interferon-induced helicase C domain-containing protein 1. (1022 aa)
LOC103090179Toll-like receptor 2-like isoform X1; Belongs to the Toll-like receptor family. (785 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
HRASGTPase HRas isoform X1. (189 aa)
IRF7Interferon regulatory factor 7. (486 aa)
RB1Retinoblastoma-associated protein isoform X1. (929 aa)
LOC103083173Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (275 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
LOC103074001LOW QUALITY PROTEIN: 14-3-3 protein zeta-like; Belongs to the 14-3-3 family. (230 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (164 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
STAT2Signal transducer and activator of transcription. (895 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
BIDBH3-interacting domain death agonist. (297 aa)
FASTumor necrosis factor receptor superfamily member 6. (342 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (293 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (456 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (747 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (752 aa)
DDX58LOW QUALITY PROTEIN: DEAD (Asp-Glu-Ala-Asp) box polypeptide 58. (886 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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