STRINGSTRING
RHOA RHOA MAPK8 MAPK8 SOS2 SOS2 KRAS KRAS GADD45G GADD45G SOS1 SOS1 SMAD3 SMAD3 LOC103079638 LOC103079638 GSK3B GSK3B MAP2K1 MAP2K1 LOC103069156 LOC103069156 RAC1 RAC1 MAPK1 MAPK1 RPS6KB1 RPS6KB1 ARAF ARAF PIK3R3 PIK3R3 RPS6KB2 RPS6KB2 APC APC PIK3CD PIK3CD APPL1 APPL1 LOC103071096 LOC103071096 MAPK3 MAPK3 LEF1 LEF1 RALGDS RALGDS TGFA TGFA AXIN1 AXIN1 DDB2 DDB2 RAC2 RAC2 GRB2 GRB2 PIK3R1 PIK3R1 AKT1 AKT1 MYC MYC AXIN2 AXIN2 LOC103072956 LOC103072956 TGFBR2 TGFBR2 BBC3 BBC3 AKT2 AKT2 TP53 TP53 CASP9 CASP9 TGFB3 TGFB3 MSH2 MSH2 MSH6 MSH6 APC2 APC2 TGFB1 TGFB1 FOS FOS POLK POLK TGFBR1 TGFBR1 MAP2K2 MAP2K2 PIK3R2 PIK3R2 GADD45B GADD45B GADD45A GADD45A JUN JUN AKT3 AKT3 MLH1 MLH1 LOC103069848 LOC103069848 AREG AREG EREG EREG BAX BAX TCF7 TCF7 BIRC5 BIRC5 RAF1 RAF1 EGFR EGFR BAD BAD MTOR MTOR NRAS NRAS RAC3 RAC3 RALA RALA BCL2 BCL2 EGF EGF MAPK9 MAPK9 SMAD4 SMAD4 MAPK10 MAPK10 LOC103075495 LOC103075495 PIK3CB PIK3CB CTNNB1 CTNNB1 PIK3CA PIK3CA SMAD2 SMAD2 CCND1 CCND1 HRAS HRAS LOC103083173 LOC103083173 CASP3 CASP3 BRAF BRAF CDKN1A CDKN1A TCF7L2 TCF7L2 RALB RALB BCL2L11 BCL2L11 LOC103083480 LOC103083480 TGFB2 TGFB2 TCF7L1 TCF7L1 MSH3 MSH3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHOATransforming protein RhoA isoform X1. (221 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SOS2Son of sevenless homolog 2-like. (1272 aa)
KRASGTPase KRas. (188 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LOC103079638Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (173 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
LOC103069156Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (201 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X2. (609 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
APCAdenomatous polyposis coli protein isoform X1. (2847 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
APPL1DCC-interacting protein 13-alpha. (708 aa)
LOC103071096DNA mismatch repair protein Msh3-like. (511 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (842 aa)
TGFAProtransforming growth factor alpha. (145 aa)
AXIN1Axin-1. (866 aa)
DDB2DNA damage-binding protein 2 isoform X1. (463 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa)
AXIN2Axin-2. (846 aa)
LOC103072956Uncharacterized protein LOC103072956. (225 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
BBC3Bcl-2-binding component 3. (193 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (452 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
APC2Adenomatous polyposis coli protein 2. (2237 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
POLKDNA polymerase kappa. (885 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (337 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MLH1DNA mismatch repair protein Mlh1 isoform X1. (757 aa)
LOC103069848Putative Bcl-2 homologous antagonist/killer 2-like. (211 aa)
AREGAmphiregulin isoform X1. (254 aa)
EREGProepiregulin. (163 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
TCF7Transcription factor 7. (252 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
BADBcl2 antagonist of cell death. (168 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
NRASGTPase NRas. (189 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (192 aa)
RALARas-related protein Ral-A. (206 aa)
BCL2Apoptosis regulator Bcl-2. (232 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
LOC103075495Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
HRASGTPase HRas isoform X1. (189 aa)
LOC103083173Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (275 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (164 aa)
TCF7L2Transcription factor 7-like 2. (584 aa)
RALBRas-related protein Ral-B. (206 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
LOC103083480LOW QUALITY PROTEIN: netrin receptor DCC-like. (1447 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TCF7L1Transcription factor 7-like 1. (713 aa)
MSH3DNA mismatch repair protein Msh3-like. (620 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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