STRINGSTRING
MAPK8 MAPK8 KRAS KRAS E2F1 E2F1 GADD45G GADD45G SMAD3 SMAD3 LOC103076219 LOC103076219 BCL2L1 BCL2L1 STAT3 STAT3 MAP2K1 MAP2K1 RAC1 RAC1 MAPK1 MAPK1 RPS6KB1 RPS6KB1 ARAF ARAF PIK3R3 PIK3R3 RPS6KB2 RPS6KB2 PIK3CD PIK3CD ARHGEF6 ARHGEF6 MAPK3 MAPK3 RALGDS RALGDS CDKN2A CDKN2A TGFA TGFA IKBKB IKBKB DDB2 DDB2 RAC2 RAC2 PIK3R1 PIK3R1 E2F3 E2F3 AKT1 AKT1 PLD2 PLD2 TGFBR2 TGFBR2 AKT2 AKT2 IKBKG IKBKG TP53 TP53 CASP9 CASP9 TGFB3 TGFB3 RALBP1 RALBP1 VEGFA VEGFA E2F2 E2F2 TGFB1 TGFB1 CDC42 CDC42 POLK POLK TGFBR1 TGFBR1 CDK6 CDK6 RELA RELA PIK3R2 PIK3R2 JAK1 JAK1 GADD45B GADD45B GADD45A GADD45A RAD51 RAD51 AKT3 AKT3 LOC103069848 LOC103069848 BAX BAX RAF1 RAF1 EGFR EGFR BRCA2 BRCA2 BAD BAD MTOR MTOR RAC3 RAC3 RALA RALA ERBB2 ERBB2 EGF EGF MAPK9 MAPK9 SMAD4 SMAD4 MAPK10 MAPK10 NFKB1 NFKB1 LOC103069117 LOC103069117 PIK3CB PIK3CB PLD1 PLD1 PIK3CA PIK3CA SMAD2 SMAD2 CCND1 CCND1 RB1 RB1 BRAF BRAF CDKN1A CDKN1A CDK4 CDK4 RALB RALB CHUK CHUK TGFB2 TGFB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK8Mitogen-activated protein kinase. (427 aa)
KRASGTPase KRas. (188 aa)
E2F1Transcription factor E2F1. (437 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LOC103076219DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
STAT3Signal transducer and activator of transcription. (654 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (201 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X2. (609 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
ARHGEF6Rho guanine nucleotide exchange factor 6. (777 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (842 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoforms 1/2/3. (152 aa)
TGFAProtransforming growth factor alpha. (145 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
DDB2DNA damage-binding protein 2 isoform X1. (463 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
E2F3Transcription factor E2F3. (469 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PLD2Phospholipase. (933 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (419 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (452 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
RALBP1ralA-binding protein 1. (635 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
E2F2Transcription factor E2F2. (439 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
POLKDNA polymerase kappa. (885 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
RELATranscription factor p65 isoform X1. (560 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC103069848Putative Bcl-2 homologous antagonist/killer 2-like. (211 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
BRCA2LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3441 aa)
BADBcl2 antagonist of cell death. (168 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (192 aa)
RALARas-related protein Ral-A. (206 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
LOC103069117LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-like. (721 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PLD1Phospholipase. (1074 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
RB1Retinoblastoma-associated protein isoform X1. (929 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (164 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RALBRas-related protein Ral-B. (206 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (747 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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