STRINGSTRING
SOS2 SOS2 SHC3 SHC3 CAMK2B CAMK2B KRAS KRAS E2F1 E2F1 CALML4 CALML4 GADD45G GADD45G SOS1 SOS1 MAP2K1 MAP2K1 CAMK2A CAMK2A PDGFRB PDGFRB PRKCB PRKCB MAPK1 MAPK1 CALML6 CALML6 ARAF ARAF PIK3R3 PIK3R3 CAMK4 CAMK4 PIK3CD PIK3CD CAMK1G CAMK1G PLCG2 PLCG2 IGF1 IGF1 MAPK3 MAPK3 CAMK2D CAMK2D CAMK1D CAMK1D CDKN2A CDKN2A TGFA TGFA PRKCA PRKCA SHC4 SHC4 DDB2 DDB2 PDGFRA PDGFRA PDGFB PDGFB GRB2 GRB2 PIK3R1 PIK3R1 E2F3 E2F3 AKT1 AKT1 SHC1 SHC1 AKT2 AKT2 TP53 TP53 E2F2 E2F2 CALM3 CALM3 PRKCG PRKCG POLK POLK SHC2 SHC2 MAP2K2 MAP2K2 CDK6 CDK6 PIK3R2 PIK3R2 GADD45B GADD45B GADD45A GADD45A AKT3 AKT3 LOC103069848 LOC103069848 BAX BAX MDM2 MDM2 RAF1 RAF1 EGFR EGFR MTOR MTOR NRAS NRAS PLCG1 PLCG1 EGF EGF PIK3CB PIK3CB PIK3CA PIK3CA PDGFA PDGFA LOC103074541 LOC103074541 CCND1 CCND1 CALML5 CALML5 HRAS HRAS RB1 RB1 BRAF BRAF CAMK2G CAMK2G CDKN1A CDKN1A CDK4 CDK4 IGF1R IGF1R PTEN PTEN CALM1 CALM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOS2Son of sevenless homolog 2-like. (1272 aa)
SHC3SHC-transforming protein 3. (588 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
KRASGTPase KRas. (188 aa)
E2F1Transcription factor E2F1. (437 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
CALML6Calmodulin-like protein 6. (190 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X2. (609 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (473 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
CAMK1GCalcium/calmodulin-dependent protein kinase type 1G isoform X2; Belongs to the protein kinase superfamily. (476 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
IGF1Insulin-like growth factor I isoform X1. (174 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
CAMK2DLOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit delta. (536 aa)
CAMK1DCalcium/calmodulin-dependent protein kinase type 1D; Belongs to the protein kinase superfamily. (385 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoforms 1/2/3. (152 aa)
TGFAProtransforming growth factor alpha. (145 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
SHC4SHC-transforming protein 4 isoform X1. (631 aa)
DDB2DNA damage-binding protein 2 isoform X1. (463 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
E2F3Transcription factor E2F3. (469 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
E2F2Transcription factor E2F2. (439 aa)
CALM3Calmodulin isoform X2; Belongs to the calmodulin family. (149 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
POLKDNA polymerase kappa. (885 aa)
SHC2SHC-transforming protein 2. (801 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC103069848Putative Bcl-2 homologous antagonist/killer 2-like. (211 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
NRASGTPase NRas. (189 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
LOC103074541LOW QUALITY PROTEIN: calmodulin-like protein 1-like; Belongs to the calmodulin family. (289 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CALML5Calmodulin-like protein 5. (140 aa)
HRASGTPase HRas isoform X1. (189 aa)
RB1Retinoblastoma-associated protein isoform X1. (929 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (672 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (164 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CALM1Calmodulin isoform X1; Belongs to the calmodulin family. (150 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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