STRINGSTRING
PAX8 PAX8 KRAS KRAS GADD45G GADD45G NCOA4 NCOA4 MAP2K1 MAP2K1 CDH1 CDH1 MAPK1 MAPK1 RET RET TPR TPR MAPK3 MAPK3 LEF1 LEF1 RXRA RXRA DDB2 DDB2 MYC MYC TPM3 TPM3 NTRK1 NTRK1 RXRG RXRG TP53 TP53 POLK POLK MAP2K2 MAP2K2 GADD45B GADD45B GADD45A GADD45A LOC103069848 LOC103069848 RXRB RXRB BAX BAX TCF7 TCF7 PPARG PPARG NRAS NRAS CTNNB1 CTNNB1 CCND1 CCND1 HRAS HRAS BRAF BRAF CDKN1A CDKN1A TCF7L2 TCF7L2 CCDC6 CCDC6 TFG TFG TCF7L1 TCF7L1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAX8Paired box protein Pax-8. (288 aa)
KRASGTPase KRas. (188 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
NCOA4Nuclear receptor coactivator 4. (624 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
CDH1Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1026 aa)
TPRNucleoprotein TPR. (2357 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
RXRARetinoic acid receptor RXR-alpha isoform X1. (439 aa)
DDB2DNA damage-binding protein 2 isoform X1. (463 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa)
TPM3Tropomyosin alpha-3 chain isoform X1; Belongs to the tropomyosin family. (284 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
RXRGRetinoic acid receptor RXR-gamma. (463 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
POLKDNA polymerase kappa. (885 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
LOC103069848Putative Bcl-2 homologous antagonist/killer 2-like. (211 aa)
RXRBRetinoic acid receptor RXR-beta isoform X1. (538 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
TCF7Transcription factor 7. (252 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
NRASGTPase NRas. (189 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
HRASGTPase HRas isoform X1. (189 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (164 aa)
TCF7L2Transcription factor 7-like 2. (584 aa)
CCDC6Coiled-coil domain-containing protein 6-like. (476 aa)
TFGProtein TFG-like isoform X1. (405 aa)
TCF7L1Transcription factor 7-like 1. (713 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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