STRINGSTRING
KRAS KRAS FGF16 FGF16 E2F1 E2F1 GADD45G GADD45G MITF MITF MAP2K1 MAP2K1 PDGFRB PDGFRB CDH1 CDH1 MET MET MAPK1 MAPK1 PDGFD PDGFD ARAF ARAF PIK3R3 PIK3R3 FGF17 FGF17 PIK3CD PIK3CD IGF1 IGF1 MAPK3 MAPK3 CDKN2A CDKN2A FGF7 FGF7 DDB2 DDB2 PDGFRA PDGFRA PDGFB PDGFB PIK3R1 PIK3R1 E2F3 E2F3 AKT1 AKT1 AKT2 AKT2 TP53 TP53 FGF22 FGF22 E2F2 E2F2 POLK POLK FGF10 FGF10 MAP2K2 MAP2K2 CDK6 CDK6 FGF20 FGF20 PIK3R2 PIK3R2 GADD45B GADD45B GADD45A GADD45A AKT3 AKT3 LOC103069848 LOC103069848 BAX BAX MDM2 MDM2 RAF1 RAF1 EGFR EGFR PDGFC PDGFC BAD BAD NRAS NRAS EGF EGF FGF21 FGF21 FGF9 FGF9 LOC103081170 LOC103081170 PIK3CB PIK3CB PIK3CA PIK3CA FGF4 FGF4 PDGFA PDGFA FGF18 FGF18 CCND1 CCND1 HRAS HRAS RB1 RB1 BRAF BRAF HGF HGF FGF1 FGF1 CDKN1A CDKN1A FGF6 FGF6 FGF23 FGF23 CDK4 CDK4 IGF1R IGF1R PTEN PTEN FGF2 FGF2 FGFR1 FGFR1 FGF8 FGF8 FGF3 FGF3 FGF5 FGF5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRASGTPase KRas. (188 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
E2F1Transcription factor E2F1. (437 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
MITFMicrophthalmia-associated transcription factor isoform X1. (520 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
CDH1Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
METHepatocyte growth factor receptor isoform X1. (1412 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
PDGFDPlatelet-derived growth factor D-like isoform X1. (370 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X2. (609 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
IGF1Insulin-like growth factor I isoform X1. (174 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoforms 1/2/3. (152 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
DDB2DNA damage-binding protein 2 isoform X1. (463 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
E2F3Transcription factor E2F3. (469 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
FGF22LOW QUALITY PROTEIN: fibroblast growth factor 22; Belongs to the heparin-binding growth factors family. (229 aa)
E2F2Transcription factor E2F2. (439 aa)
POLKDNA polymerase kappa. (885 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC103069848Putative Bcl-2 homologous antagonist/killer 2-like. (211 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PDGFCPlatelet-derived growth factor C. (345 aa)
BADBcl2 antagonist of cell death. (168 aa)
NRASGTPase NRas. (189 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC103081170Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (465 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
HRASGTPase HRas isoform X1. (189 aa)
RB1Retinoblastoma-associated protein isoform X1. (929 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (164 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (373 aa)
FGFR1Fibroblast growth factor receptor. (837 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (232 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (266 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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