STRINGSTRING
SOS2 SOS2 EML4 EML4 KRAS KRAS E2F1 E2F1 STAT5B STAT5B GADD45G GADD45G SOS1 SOS1 FOXO3 FOXO3 STAT5A STAT5A STAT3 STAT3 MAP2K1 MAP2K1 MET MET PRKCB PRKCB MAPK1 MAPK1 ARAF ARAF PIK3R3 PIK3R3 PIK3CD PIK3CD LOC103080293 LOC103080293 RASSF1 RASSF1 PLCG2 PLCG2 MAPK3 MAPK3 RXRA RXRA CDKN2A CDKN2A TGFA TGFA PRKCA PRKCA PDPK1 PDPK1 DDB2 DDB2 GRB2 GRB2 PIK3R1 PIK3R1 E2F3 E2F3 AKT1 AKT1 AKT2 AKT2 RXRG RXRG TP53 TP53 CASP9 CASP9 E2F2 E2F2 PRKCG PRKCG POLK POLK MAP2K2 MAP2K2 CDK6 CDK6 JAK3 JAK3 PIK3R2 PIK3R2 GADD45B GADD45B GADD45A GADD45A AKT3 AKT3 LOC103069848 LOC103069848 RXRB RXRB BAX BAX RAF1 RAF1 EGFR EGFR BAD BAD NRAS NRAS PLCG1 PLCG1 ERBB2 ERBB2 EGF EGF RARB RARB PIK3CB PIK3CB STK4 STK4 PIK3CA PIK3CA CCND1 CCND1 HRAS HRAS RB1 RB1 BRAF BRAF HGF HGF CDKN1A CDKN1A CDK4 CDK4 ALK ALK RASSF5 RASSF5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOS2Son of sevenless homolog 2-like. (1272 aa)
EML4Echinoderm microtubule-associated protein-like 4 isoform X2. (1006 aa)
KRASGTPase KRas. (188 aa)
E2F1Transcription factor E2F1. (437 aa)
STAT5BSignal transducer and activator of transcription. (792 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
FOXO3Forkhead box protein O3. (672 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT3Signal transducer and activator of transcription. (654 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
METHepatocyte growth factor receptor isoform X1. (1412 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X2. (609 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
LOC103080293Bis(5'-adenosyl)-triphosphatase. (149 aa)
RASSF1Ras association domain-containing protein 1 isoform X3. (344 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
RXRARetinoic acid receptor RXR-alpha isoform X1. (439 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoforms 1/2/3. (152 aa)
TGFAProtransforming growth factor alpha. (145 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
DDB2DNA damage-binding protein 2 isoform X1. (463 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
E2F3Transcription factor E2F3. (469 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
RXRGRetinoic acid receptor RXR-gamma. (463 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (452 aa)
E2F2Transcription factor E2F2. (439 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
POLKDNA polymerase kappa. (885 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC103069848Putative Bcl-2 homologous antagonist/killer 2-like. (211 aa)
RXRBRetinoic acid receptor RXR-beta isoform X1. (538 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
BADBcl2 antagonist of cell death. (168 aa)
NRASGTPase NRas. (189 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
RARBRetinoic acid receptor beta isoform X1. (458 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
HRASGTPase HRas isoform X1. (189 aa)
RB1Retinoblastoma-associated protein isoform X1. (929 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (164 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ALKTyrosine-protein kinase receptor. (1619 aa)
RASSF5Ras association domain-containing protein 5 isoform X1. (420 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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