STRINGSTRING
FZD8 FZD8 SOS2 SOS2 SHC3 SHC3 WNT10A WNT10A KRAS KRAS CSNK1A1 CSNK1A1 E2F1 E2F1 WNT6 WNT6 MGST2 MGST2 ACTB ACTB LOC103079434 LOC103079434 SMARCC1 SMARCC1 GADD45G GADD45G SOS1 SOS1 PHF10 PHF10 LOC103091064 LOC103091064 FZD4 FZD4 SMAD3 SMAD3 GSTM3 GSTM3 BCL2L1 BCL2L1 DVL1 DVL1 WNT7A WNT7A LRP5 LRP5 GSK3B GSK3B MAP2K1 MAP2K1 NQO1 NQO1 MET MET PRKCB PRKCB MAPK1 MAPK1 SMARCB1 SMARCB1 LOC103082472 LOC103082472 NFE2L2 NFE2L2 ARID1B ARID1B RPS6KB1 RPS6KB1 LOC103081925 LOC103081925 PBRM1 PBRM1 GSTA4 GSTA4 SMARCD1 SMARCD1 LOC103070610 LOC103070610 LOC103079831 LOC103079831 ARAF ARAF PIK3R3 PIK3R3 WNT1 WNT1 RPS6KB2 RPS6KB2 LOC103082194 LOC103082194 APC APC ELK1 ELK1 PIK3CD PIK3CD WNT2 WNT2 GSTA2 GSTA2 FZD1 FZD1 PLCG2 PLCG2 MAPK3 MAPK3 LEF1 LEF1 WNT10B WNT10B MGST1 MGST1 CDKN2A CDKN2A TGFA TGFA PRKCA PRKCA SHC4 SHC4 AXIN1 AXIN1 DDB2 DDB2 WNT7B WNT7B FRAT1 FRAT1 LOC103076632 LOC103076632 WNT3A WNT3A GRB2 GRB2 PIK3R1 PIK3R1 E2F3 E2F3 AKT1 AKT1 DPF3 DPF3 MYC MYC AXIN2 AXIN2 HMOX1 HMOX1 SHC1 SHC1 TGFBR2 TGFBR2 WNT5A WNT5A FRAT2 FRAT2 AKT2 AKT2 WNT9A WNT9A SMARCD2 SMARCD2 TP53 TP53 ARID1A ARID1A BRD7 BRD7 TGFB3 TGFB3 MGST3 MGST3 DVL2 DVL2 TXNRD2 TXNRD2 WNT2B WNT2B APC2 APC2 E2F2 E2F2 WNT4 WNT4 WNT16 WNT16 SMARCA4 SMARCA4 TGFB1 TGFB1 PRKCG PRKCG POLK POLK TGFBR1 TGFBR1 WNT11 WNT11 SHC2 SHC2 MAP2K2 MAP2K2 CDK6 CDK6 KEAP1 KEAP1 PIK3R2 PIK3R2 ACTG1 ACTG1 GADD45B GADD45B GADD45A GADD45A AKT3 AKT3 LOC103069848 LOC103069848 BAX BAX TCF7 TCF7 WNT8A WNT8A RAF1 RAF1 FZD5 FZD5 EGFR EGFR ARID2 ARID2 BAD BAD MTOR MTOR NRAS NRAS PLCG1 PLCG1 FZD6 FZD6 SMAD4 SMAD4 GAB1 GAB1 FZD3 FZD3 LOC103071337 LOC103071337 PIK3CB PIK3CB CTNNB1 CTNNB1 ACTL6A ACTL6A PIK3CA PIK3CA WNT9B WNT9B SMARCE1 SMARCE1 WNT3 WNT3 TXNRD3 TXNRD3 SMAD2 SMAD2 SMARCA2 SMARCA2 CCND1 CCND1 HRAS HRAS IGF2 IGF2 LOC103075878 LOC103075878 RB1 RB1 LOC103087422 LOC103087422 LOC103089486 LOC103089486 BRAF BRAF HGF HGF FZD7 FZD7 FZD9 FZD9 CDKN1A CDKN1A TCF7L2 TCF7L2 CDK4 CDK4 SMARCC2 SMARCC2 ACTL6B ACTL6B IGF1R IGF1R PTEN PTEN GSTO2 GSTO2 WNT5B WNT5B DVL3 DVL3 WNT8B WNT8B LRP6 LRP6 SMARCD3 SMARCD3 TERT TERT FZD10 FZD10 LOC103090726 LOC103090726 TGFB2 TGFB2 TCF7L1 TCF7L1 GSTM1 GSTM1 DPF1 DPF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FZD8LOW QUALITY PROTEIN: frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (672 aa)
SOS2Son of sevenless homolog 2-like. (1272 aa)
SHC3SHC-transforming protein 3. (588 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
KRASGTPase KRas. (188 aa)
CSNK1A1Casein kinase I isoform alpha isoform X1; Belongs to the protein kinase superfamily. (365 aa)
E2F1Transcription factor E2F1. (437 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
MGST2LOW QUALITY PROTEIN: microsomal glutathione S-transferase 2. (154 aa)
ACTBActin, cytoplasmic 1. (375 aa)
LOC103079434Glutathione S-transferase theta-1-like. (207 aa)
SMARCC1SWI/SNF complex subunit SMARCC1. (996 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
PHF10PHD finger protein 10 isoform X1. (574 aa)
LOC103091064Thioredoxin reductase 1, cytoplasmic-like isoform X1. (497 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
GSTM3Glutathione S-transferase. (225 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X2. (699 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1451 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
NQO1LOW QUALITY PROTEIN: NAD(P)H dehydrogenase [quinone] 1. (222 aa)
METHepatocyte growth factor receptor isoform X1. (1412 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa)
LOC103082472Glutathione S-transferase theta-1-like; Belongs to the GST superfamily. (240 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X1. (615 aa)
ARID1BAT-rich interactive domain-containing protein 1B. (2101 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
LOC103081925Glutathione S-transferase theta-1-like; Belongs to the GST superfamily. (195 aa)
PBRM1LOW QUALITY PROTEIN: protein polybromo-1. (1581 aa)
GSTA4Glutathione S-transferase A4. (223 aa)
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (515 aa)
LOC103070610Glutathione S-transferase P-like; Belongs to the GST superfamily. (237 aa)
LOC103079831Glutathione S-transferase P-like; Belongs to the GST superfamily. (282 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X2. (609 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
LOC103082194Glutathione S-transferase theta-4-like; Belongs to the GST superfamily. (241 aa)
APCAdenomatous polyposis coli protein isoform X1. (2847 aa)
ELK1ETS domain-containing protein Elk-1 isoform X1. (444 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
GSTA2Glutathione S-transferase. (223 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoforms 1/2/3. (152 aa)
TGFAProtransforming growth factor alpha. (145 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
SHC4SHC-transforming protein 4 isoform X1. (631 aa)
AXIN1Axin-1. (866 aa)
DDB2DNA damage-binding protein 2 isoform X1. (463 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
FRAT1Proto-oncogene FRAT1. (277 aa)
LOC103076632Frizzled-2-like; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
E2F3Transcription factor E2F3. (469 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
DPF3Zinc finger protein DPF3. (461 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa)
AXIN2Axin-2. (846 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FRAT2GSK-3-binding protein FRAT2. (230 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SMARCD2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2. (531 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
ARID1AAT-rich interactive domain-containing protein 1A. (2224 aa)
BRD7Bromodomain-containing protein 7 isoform X1. (652 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
MGST3Microsomal glutathione S-transferase 3. (152 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2. (734 aa)
TXNRD2Thioredoxin reductase 2, mitochondrial. (425 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
APC2Adenomatous polyposis coli protein 2. (2237 aa)
E2F2Transcription factor E2F2. (439 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
SMARCA4Transcription activator BRG1. (1619 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
POLKDNA polymerase kappa. (885 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SHC2SHC-transforming protein 2. (801 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
KEAP1Kelch-like ECH-associated protein 1. (624 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC103069848Putative Bcl-2 homologous antagonist/killer 2-like. (211 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
TCF7Transcription factor 7. (252 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
ARID2AT-rich interactive domain-containing protein 2. (1835 aa)
BADBcl2 antagonist of cell death. (168 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
NRASGTPase NRas. (189 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (723 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
LOC103071337Glutathione S-transferase 1, isoform D-like; Belongs to the GST superfamily. (200 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
ACTL6AActin-like protein 6A isoform X1; Belongs to the actin family. (468 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
TXNRD3Thioredoxin reductase 3. (620 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMARCA2Probable global transcription activator SNF2L2-like isoform X1. (1559 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
HRASGTPase HRas isoform X1. (189 aa)
IGF2Insulin-like growth factor II isoform X1. (237 aa)
LOC103075878Glutathione S-transferase U2-like; Belongs to the GST superfamily. (244 aa)
RB1Retinoblastoma-associated protein isoform X1. (929 aa)
LOC103087422Glutathione S-transferase 3-like. (182 aa)
LOC103089486Glutathione S-transferase U4-like; Belongs to the GST superfamily. (219 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (545 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (164 aa)
TCF7L2Transcription factor 7-like 2. (584 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
SMARCC2SWI/SNF complex subunit SMARCC2. (1019 aa)
ACTL6BActin-like protein 6B; Belongs to the actin family. (426 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
GSTO2Glutathione S-transferase omega-2 isoform X1; Belongs to the GST superfamily. (216 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (322 aa)
LRP6Low-density lipoprotein receptor-related protein 6 isoform X1. (1463 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1127 aa)
FZD10LOW QUALITY PROTEIN: frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (563 aa)
LOC103090726Probable glutathione S-transferase GSTF1-like. (207 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TCF7L1Transcription factor 7-like 1. (713 aa)
GSTM1LOW QUALITY PROTEIN: glutathione S-transferase mu 1; Belongs to the GST superfamily. (226 aa)
DPF1Zinc finger protein neuro-d4 isoform X1. (475 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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