STRINGSTRING
KRAS KRAS LOC103088591 LOC103088591 NTRK3 NTRK3 GCK GCK LDHB LDHB LOC103084379 LOC103084379 MAP2K1 MAP2K1 PDGFRB PDGFRB MET MET MAPK1 MAPK1 RET RET LOC103084848 LOC103084848 PIK3R3 PIK3R3 PFKL PFKL HK2 HK2 PIK3CD PIK3CD LOC103075632 LOC103075632 MAPK3 MAPK3 SLC2A1 SLC2A1 HK1 HK1 PDGFRA PDGFRA HKDC1 HKDC1 PGAM1 PGAM1 PIK3R1 PIK3R1 AKT1 AKT1 MYC MYC G6PD G6PD NTRK1 NTRK1 KIT KIT AKT2 AKT2 PDK1 PDK1 LOC103078558 LOC103078558 TP53 TP53 SLC1A5 SLC1A5 MAP2K2 MAP2K2 SLC16A3 SLC16A3 PIK3R2 PIK3R2 AKT3 AKT3 SIRT6 SIRT6 RAF1 RAF1 EGFR EGFR MTOR MTOR NRAS NRAS SLC2A2 SLC2A2 GLS GLS ERBB2 ERBB2 HK3 HK3 PGAM2 PGAM2 IDH1 IDH1 PFKP PFKP LDHA LDHA PIK3CB PIK3CB PIK3CA PIK3CA SIRT3 SIRT3 LDHC LDHC FGFR3 FGFR3 HRAS HRAS PKM PKM PFKM PFKM PDHB PDHB GLS2 GLS2 PTEN PTEN PDHA1 PDHA1 LOC103077691 LOC103077691 SLC7A5 SLC7A5 FGFR2 FGFR2 FGFR1 FGFR1 IDH2 IDH2 FLT3 FLT3 HIF1A HIF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRASGTPase KRas. (188 aa)
LOC103088591Uncharacterized protein LOC103088591. (856 aa)
NTRK3Tyrosine-protein kinase receptor. (839 aa)
GCKPhosphotransferase. (466 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
LOC103084379Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (394 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
METHepatocyte growth factor receptor isoform X1. (1412 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1026 aa)
LOC103084848Isocitrate dehydrogenase [NADP]. (418 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (781 aa)
HK2Hexokinase-2 isoform X1. (1002 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
LOC103075632Protein SCO2 homolog, mitochondrial-like. (266 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1-like; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
HK1Hexokinase-1. (917 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
HKDC1Putative hexokinase HKDC1. (917 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (543 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
LOC103078558Isocitrate dehydrogenase [NADP] cytoplasmic-like. (214 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
SLC1A5Amino acid transporter. (541 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SLC16A3Monocarboxylate transporter 4. (461 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform X1. (359 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
NRASGTPase NRas. (189 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
GLSGlutaminase kidney isoform, mitochondrial. (311 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
HK3Hexokinase-3. (924 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (791 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (334 aa)
LDHCL-lactate dehydrogenase C chain. (167 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
HRASGTPase HRas isoform X1. (189 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (853 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
GLS2Glutaminase liver isoform, mitochondrial isoform X1. (602 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
LOC103077691Fructose-2,6-bisphosphatase TIGAR. (269 aa)
SLC7A5Large neutral amino acids transporter small subunit 1. (496 aa)
FGFR2Fibroblast growth factor receptor. (839 aa)
FGFR1Fibroblast growth factor receptor. (837 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (973 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (822 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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