STRINGSTRING
BMP4 BMP4 RHOA RHOA MAPK8 MAPK8 IL1B IL1B SRC SRC MGST2 MGST2 ACTB ACTB LOC103079434 LOC103079434 CALML4 CALML4 TRPV4 TRPV4 EDN1 EDN1 LOC103084808 LOC103084808 IL1A IL1A ACVR1 ACVR1 MAP2K5 MAP2K5 LOC103089492 LOC103089492 TXN2 TXN2 GSTM3 GSTM3 TXN TXN LOC103081641 LOC103081641 VCAM1 VCAM1 LOC103086710 LOC103086710 LOC103073174 LOC103073174 CTSL CTSL RAC1 RAC1 NQO1 NQO1 CAV2 CAV2 PRKCZ PRKCZ MAPK7 MAPK7 LOC103082472 LOC103082472 NFE2L2 NFE2L2 CALML6 CALML6 LOC103081925 LOC103081925 GSTA4 GSTA4 MMP9 MMP9 LOC103070610 LOC103070610 LOC103079831 LOC103079831 KDR KDR NCF2 NCF2 PIK3R3 PIK3R3 LOC103082194 LOC103082194 PIK3CD PIK3CD CAV1 CAV1 GSTA2 GSTA2 MAPK11 MAPK11 MAP3K7 MAP3K7 HSP90B1 HSP90B1 SDC2 SDC2 MGST1 MGST1 ITGA2B ITGA2B LOC103084028 LOC103084028 ASS1 ASS1 IKBKB IKBKB HSP90AA1 HSP90AA1 MAPK12 MAPK12 RAC2 RAC2 PDGFB PDGFB LOC103070012 LOC103070012 SUMO2 SUMO2 LOC103075562 LOC103075562 LOC103082678 LOC103082678 ACVR2A ACVR2A PIK3R1 PIK3R1 AKT1 AKT1 MAP2K4 MAP2K4 CDH5 CDH5 LOC103072956 LOC103072956 HMOX1 HMOX1 PLAT PLAT ARHGEF2 ARHGEF2 ITGB3 ITGB3 SELE SELE PECAM1 PECAM1 BMPR1A BMPR1A CCL2 CCL2 AKT2 AKT2 IKBKG IKBKG LOC103069948 LOC103069948 TP53 TP53 LOC103090930 LOC103090930 HSP90AB1 HSP90AB1 LOC103070113 LOC103070113 MGST3 MGST3 LOC103070382 LOC103070382 THBD THBD VEGFA VEGFA MAP2K7 MAP2K7 CALM3 CALM3 ICAM1 ICAM1 MMP2 MMP2 MEF2A MEF2A TNF TNF FOS FOS KEAP1 KEAP1 RELA RELA PIK3R2 PIK3R2 ACTG1 ACTG1 JUN JUN AKT3 AKT3 NPPC NPPC PIAS4 PIAS4 KLF2 KLF2 IFNG IFNG ACVR2B ACVR2B BMPR1B BMPR1B RAC3 RAC3 PRKAA2 PRKAA2 SDC4 SDC4 BCL2 BCL2 LOC103074911 LOC103074911 MAPK9 MAPK9 MAPK10 MAPK10 CAV3 CAV3 SDC1 SDC1 NFKB1 NFKB1 LOC103071337 LOC103071337 PIK3CB PIK3CB SQSTM1 SQSTM1 CTNNB1 CTNNB1 DUSP1 DUSP1 PTK2 PTK2 PIK3CA PIK3CA MAPK14 MAPK14 PDGFA PDGFA MEF2C MEF2C MAPK13 MAPK13 LOC103074541 LOC103074541 NOX1 NOX1 CALML5 CALML5 LOC103075878 LOC103075878 LOC103090543 LOC103090543 LOC103087422 LOC103087422 LOC103089486 LOC103089486 BMPR2 BMPR2 LOC103069346 LOC103069346 TNFRSF1A TNFRSF1A LOC103072080 LOC103072080 GPC1 GPC1 GSTO2 GSTO2 NCF1 NCF1 SUMO1 SUMO1 CHUK CHUK PRKAA1 PRKAA1 NOS3 NOS3 LOC103090726 LOC103090726 GSTM1 GSTM1 CALM1 CALM1 ITGAV ITGAV
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
RHOATransforming protein RhoA isoform X1. (221 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
SRCTyrosine-protein kinase. (548 aa)
MGST2LOW QUALITY PROTEIN: microsomal glutathione S-transferase 2. (154 aa)
ACTBActin, cytoplasmic 1. (375 aa)
LOC103079434Glutathione S-transferase theta-1-like. (207 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (863 aa)
EDN1Endothelin-1. (202 aa)
LOC103084808Small ubiquitin-related modifier 2-like. (76 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5-like. (282 aa)
LOC103089492Cathepsin L1-like; Belongs to the peptidase C1 family. (333 aa)
TXN2Thioredoxin, mitochondrial. (166 aa)
GSTM3Glutathione S-transferase. (225 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
LOC103081641LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6-like; Belongs to the protein kinase superfamily. (394 aa)
VCAM1Vascular cell adhesion protein 1 isoform X1. (739 aa)
LOC103086710Argininosuccinate synthase, chloroplastic-like. (405 aa)
LOC103073174Heat shock cognate 90 kDa protein-like. (634 aa)
CTSLCathepsin L1; Belongs to the peptidase C1 family. (332 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (201 aa)
NQO1LOW QUALITY PROTEIN: NAD(P)H dehydrogenase [quinone] 1. (222 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (774 aa)
LOC103082472Glutathione S-transferase theta-1-like; Belongs to the GST superfamily. (240 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X1. (615 aa)
CALML6Calmodulin-like protein 6. (190 aa)
LOC103081925Glutathione S-transferase theta-1-like; Belongs to the GST superfamily. (195 aa)
GSTA4Glutathione S-transferase A4. (223 aa)
MMP9Matrix metalloproteinase-9. (708 aa)
LOC103070610Glutathione S-transferase P-like; Belongs to the GST superfamily. (237 aa)
LOC103079831Glutathione S-transferase P-like; Belongs to the GST superfamily. (282 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
NCF2Neutrophil cytosol factor 2 isoform X1. (526 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
LOC103082194Glutathione S-transferase theta-4-like; Belongs to the GST superfamily. (241 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
GSTA2Glutathione S-transferase. (223 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
HSP90B1Endoplasmin. (803 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
ITGA2BIntegrin alpha-IIb; Belongs to the integrin alpha chain family. (1035 aa)
LOC103084028LOW QUALITY PROTEIN: interleukin-1 receptor type 1-like. (592 aa)
ASS1Argininosuccinate synthase. (412 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (732 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
LOC103070012Small ubiquitin-related modifier. (101 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
LOC103075562Thioredoxin; Belongs to the thioredoxin family. (108 aa)
LOC103082678Thioredoxin; Belongs to the thioredoxin family. (111 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (410 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (782 aa)
LOC103072956Uncharacterized protein LOC103072956. (225 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X1. (987 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
SELEE-selectin isoform X1. (554 aa)
PECAM1Platelet endothelial cell adhesion molecule. (779 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CCL2C-C motif chemokine. (99 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (419 aa)
LOC103069948LOW QUALITY PROTEIN: interleukin-1 receptor type 2-like. (450 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
LOC103090930Small ubiquitin-related modifier. (98 aa)
HSP90AB1Heat shock protein HSP 90-beta isoform X1. (724 aa)
LOC103070113Small ubiquitin-related modifier. (117 aa)
MGST3Microsomal glutathione S-transferase 3. (152 aa)
LOC103070382Argininosuccinate synthase, chloroplastic-like. (380 aa)
THBDThrombomodulin. (584 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
CALM3Calmodulin isoform X2; Belongs to the calmodulin family. (149 aa)
ICAM1Intercellular adhesion molecule 1. (536 aa)
MMP272 kDa type IV collagenase. (584 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X1. (503 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
KEAP1Kelch-like ECH-associated protein 1. (624 aa)
RELATranscription factor p65 isoform X1. (560 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (337 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NPPCC-type natriuretic peptide. (126 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (513 aa)
KLF2Krueppel-like factor 2. (355 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (192 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
SDC4Syndecan-4. (201 aa)
BCL2Apoptosis regulator Bcl-2. (232 aa)
LOC103074911Heat shock cognate 90 kDa protein-like. (518 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
LOC103071337Glutathione S-transferase 1, isoform D-like; Belongs to the GST superfamily. (200 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
SQSTM1Sequestosome-1. (440 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
PTK2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1003 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (483 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
LOC103074541LOW QUALITY PROTEIN: calmodulin-like protein 1-like; Belongs to the calmodulin family. (289 aa)
NOX1LOW QUALITY PROTEIN: NADPH oxidase 1. (562 aa)
CALML5Calmodulin-like protein 5. (140 aa)
LOC103075878Glutathione S-transferase U2-like; Belongs to the GST superfamily. (244 aa)
LOC103090543Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (192 aa)
LOC103087422Glutathione S-transferase 3-like. (182 aa)
LOC103089486Glutathione S-transferase U4-like; Belongs to the GST superfamily. (219 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
LOC103069346Small ubiquitin-related modifier 2-like. (75 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (445 aa)
LOC103072080Small ubiquitin-related modifier. (106 aa)
GPC1Glypican-1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (560 aa)
GSTO2Glutathione S-transferase omega-2 isoform X1; Belongs to the GST superfamily. (216 aa)
NCF1Neutrophil cytosol factor 1. (393 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (747 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
LOC103090726Probable glutathione S-transferase GSTF1-like. (207 aa)
GSTM1LOW QUALITY PROTEIN: glutathione S-transferase mu 1; Belongs to the GST superfamily. (226 aa)
CALM1Calmodulin isoform X1; Belongs to the calmodulin family. (150 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (1311 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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