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ilvG-1 ilvG-1 acnB acnB APB32523.1 APB32523.1 leuA-1 leuA-1 glcD glcD maeA maeA ilvC ilvC putA putA acs acs gabD gabD leuC leuC gltA gltA glcF glcF ilvG-2 ilvG-2 glcE glcE ilvG-3 ilvG-3 leuD leuD APB33982.1 APB33982.1 ldh ldh APB34103.1 APB34103.1 APB34154.1 APB34154.1 APB34157.1 APB34157.1 APB34258.1 APB34258.1 leuA-2 leuA-2 APB34372.1 APB34372.1 APB34423.1 APB34423.1 alsD alsD leuB leuB sdhA sdhA APB34558.1 APB34558.1 ilvN ilvN fumC fumC nemA nemA sdhB sdhB ilvD ilvD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ilvG-1Acetolactate synthase. (59 aa)
acnBBifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Belongs to the aconitase/IPM isomerase family. (842 aa)
APB32523.1Sodium:dicarboxylate symporter; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (437 aa)
leuA-12-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (489 aa)
glcDGlycolate oxidase subunit GlcD. (481 aa)
maeAMalic enzyme, NAD-binding. (463 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa)
putADelta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (966 aa)
acsacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa)
gabDAldehyde dehydrogenase. (460 aa)
leuCIsopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (465 aa)
gltACitrate synthase; Belongs to the citrate synthase family. (382 aa)
glcFGlycolate oxidase, iron-sulfur subunit. (449 aa)
ilvG-2Acetolactate synthase; Belongs to the TPP enzyme family. (545 aa)
glcEFAD linked oxidase domain-containing protein. (418 aa)
ilvG-3Acetolactate synthase, large subunit, biosynthetic type. (595 aa)
leuDIsopropylmalate isomerase small subunit; Belongs to the LeuD family. (190 aa)
APB33982.1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (526 aa)
ldhL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (318 aa)
APB34103.1Transporter, SSS family protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (574 aa)
APB34154.1Transposase IS5 family. (127 aa)
APB34157.1Transposase ISL2 family protein. (57 aa)
APB34258.1Isocitrate dehydrogenase. (479 aa)
leuA-2Alpha-isopropylmalate/homocitrate synthase family transferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (535 aa)
APB34372.12-hydroxyhepta-2,4-diene-1,7-dioate isomerase. (252 aa)
APB34423.1Small subunit of soluble hydrogenase. (384 aa)
alsDAlpha-acetolactate decarboxylase. (271 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (361 aa)
sdhASuccinate dehydrogenase flavoprotein subunit. (629 aa)
APB34558.1Hypothetical protein. (216 aa)
ilvNAcetolactate synthase, small subunit. (173 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (477 aa)
nemAXenobiotic reductase B. (364 aa)
sdhBSuccinate dehydrogenase and fumarate reductase iron-sulfur protein. (243 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (562 aa)
Your Current Organism:
Gloeomargarita lithophora
NCBI taxonomy Id: 1188229
Other names: Candidatus Gloeomargarita lithophora D10, G. lithophora Alchichica-D10, Gloeomargarita lithophora Alchichica-D10, Gloeomargarita lithophora PMC 919.15
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