STRINGSTRING
rluB rluB APB32463.1 APB32463.1 rluD rluD aroH aroH APB32589.1 APB32589.1 APB32698.1 APB32698.1 APB32737.1 APB32737.1 groL groL pheA2 pheA2 APB33100.1 APB33100.1 rfbC rfbC trpF trpF rpiA rpiA manB manB fcl fcl APB33301.1 APB33301.1 tig tig gyrA-1 gyrA-1 hemL hemL alr alr hisA hisA nanE nanE APB33661.1 APB33661.1 nnrE nnrE purE purE pgi pgi gpmI gpmI APB33965.1 APB33965.1 APB34064.1 APB34064.1 ppiB ppiB queA queA tpiA tpiA APB34344.1 APB34344.1 cbiC cbiC dapF dapF sqhC sqhC topA topA truA truA murI murI APB34477.1 APB34477.1 wecB wecB groL-2 groL-2 pgm pgm gyrA-2 gyrA-2 APB34889.1 APB34889.1 mtnA mtnA gyrB gyrB rluE rluE truB truB crtH crtH APB35198.1 APB35198.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
rluBPseudouridine synthase; Belongs to the pseudouridine synthase RsuA family. (242 aa)
APB32463.1NAD dependent epimerase/dehydratase family. (335 aa)
rluDRibosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (325 aa)
aroHChorismate mutase of the AroH class; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (126 aa)
APB32589.1ABC-type uncharacterized transport systems, ATPase components. (874 aa)
APB32698.1UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (327 aa)
APB32737.1Hypothetical protein. (236 aa)
groLChaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (559 aa)
pheA2Prephenate dehydratase domain protein. (282 aa)
APB33100.1Cyclophilin type peptidyl-prolyl cis-trans isomerase. (400 aa)
rfbCdTDP-6-deoxy-L-mannose-dehydrogenase. (188 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (210 aa)
rpiARibose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (236 aa)
manBPhosphoglucosamine mutase. (495 aa)
fclGDP-fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (312 aa)
APB33301.1Peptidyl-prolyl cis-trans isomerase, FKBP-type domain protein. (177 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (497 aa)
gyrA-1DNA topoisomerase IV subunit A. (755 aa)
hemLGlutamate-1-semialdehyde aminotransferase. (434 aa)
alrAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (393 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (256 aa)
nanEBifunctional enzyme NanE/nanK; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (226 aa)
APB33661.1Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (229 aa)
nnrEHypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] (518 aa)
purEPhosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (529 aa)
gpmIPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (532 aa)
APB33965.1Putative bifunctional glutamate-1-semialdehyde 2,1-aminomutase/3-deoxy-manno-octulosonate cytidylyltransferase. (676 aa)
APB34064.1Phosphoglucomutase/phosphomannomutase, C-terminal domain family. (468 aa)
ppiBPeptidyl-prolyl cis-trans isomerase cyclophilin type; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (241 aa)
queAS-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (366 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (246 aa)
APB34344.1Putative membrane protein. (230 aa)
cbiCprecorrin-8X methylmutase. (212 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (281 aa)
sqhCSqualene/oxidosqualene cyclase. (651 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (874 aa)
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (259 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (269 aa)
APB34477.1Nucleotidyl transferase. (838 aa)
wecBUDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (367 aa)
groL-2Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (542 aa)
pgmPhosphoglucomutase. (544 aa)
gyrA-2DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (826 aa)
APB34889.1Aldose 1-epimerase. (288 aa)
mtnATranslation initiation factor IF-2B subunit alpha; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (344 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (644 aa)
rluEPutative pseudouridylate synthase; Belongs to the pseudouridine synthase RsuA family. (191 aa)
truBtRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (296 aa)
crtHCarotene isomerase. (495 aa)
APB35198.1UDP-glucose 4-epimerase. (308 aa)
Your Current Organism:
Gloeomargarita lithophora
NCBI taxonomy Id: 1188229
Other names: Candidatus Gloeomargarita lithophora D10, G. lithophora Alchichica-D10, Gloeomargarita lithophora Alchichica-D10, Gloeomargarita lithophora PMC 919.15
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