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rpmD rpmD rplO rplO rpmJ rpmJ rpsM rpsM rpsK rpsK rpsD rpsD rplQ rplQ hpf hpf rpmB rpmB rpmG rpmG GAO32098.1 GAO32098.1 sspB sspB rpsF rpsF priB priB rpsR rpsR rplI rplI GAO32005.1 GAO32005.1 rpsP rpsP rimM rimM rplS rplS rplX rplX dnaA_2 dnaA_2 dnaG dnaG rpsU rpsU GAO34501.1 GAO34501.1 GAO34444.1 GAO34444.1 GAO34397.1 GAO34397.1 rpsT rpsT recQ recQ rplY rplY rpsA rpsA ihfB_2 ihfB_2 gyrB gyrB slmA_3 slmA_3 gyrA gyrA draG draG recO recO recR recR ybaB ybaB rpsI rpsI rplM rplM holC holC GAO33635.1 GAO33635.1 clpS clpS slmA_2 slmA_2 rpmE rpmE recN recN rarA rarA ihfB_1 ihfB_1 topA topA parB parB slmA_1 slmA_1 yvqK yvqK GAO33022.1 GAO33022.1 fliR fliR fliQ fliQ fliP fliP fliO fliO fliN fliN fliM fliM GAO32951.1 GAO32951.1 fliK fliK fliJ fliJ fliH fliH fliG fliG fliF fliF fliE fliE dnaB dnaB GAO32834.1 GAO32834.1 rpsO rpsO parC parC parE parE flgB flgB flgC flgC flgE flgE flgF flgF flgG flgG flgH flgH flgI flgI flgK flgK flgL flgL rpmF rpmF rplU rplU rpmA rpmA rpmI rpmI rplT rplT rpmH rpmH priA priA fis fis rpsB rpsB ycgR ycgR GAO32362.1 GAO32362.1 fliD fliD hag_2 hag_2 hag_1 hag_1 rplK rplK rplA rplA rplJ rplJ rplL rplL rpsL rpsL rpsG rpsG rpsJ rpsJ rplC rplC rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplP rplP rpmC rpmC rpsQ rpsQ rplN rplN rplE rplE rpsN rpsN rpsH rpsH rplF rplF rplR rplR rpsE rpsE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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rpmD50S ribosomal protein L30. (61 aa)
rplO50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa)
rpmJ50S ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
rpsM30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (121 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (130 aa)
rpsD30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (209 aa)
rplQ50S ribosomal protein L17. (130 aa)
hpfRibosome hibernation promoting factor. (107 aa)
rpmB50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (78 aa)
rpmG50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (55 aa)
GAO32098.1Chemotaxis regulator CheZ; Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P). (239 aa)
sspBStringent starvation protein B. (134 aa)
rpsF30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (126 aa)
priBPrimosomal replication protein n; Binds single-stranded DNA at the primosome assembly site (PAS). (81 aa)
rpsR30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (89 aa)
rplI50S ribosomal protein L9; Binds to the 23S rRNA. (149 aa)
GAO32005.1Putative ribosomal oxygenase. (387 aa)
rpsP30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (84 aa)
rimMRibosome maturation factor RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (166 aa)
rplS50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (121 aa)
rplX50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (104 aa)
dnaA_2Chromosomal replication initiator protein DnaA. (258 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (577 aa)
rpsU30S ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (70 aa)
GAO34501.1Nuclease-related domain protein. (134 aa)
GAO34444.1Restriction endonuclease. (211 aa)
GAO34397.1Hypothetical protein. (897 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (87 aa)
recQATP-dependent DNA helicase RecQ. (605 aa)
rplY50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (199 aa)
rpsA30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (568 aa)
ihfB_2Integration host factor subunit beta; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (95 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (793 aa)
slmA_3Nucleoid occlusion factor SlmA. (204 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (861 aa)
draGADP-ribosyl-[dinitrogen reductase] glycohydrolase. (297 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (240 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa)
ybaBNucleoid-associated protein YbaB; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (108 aa)
rpsI30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (130 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (145 aa)
holCDNA polymerase III subunit chi. (172 aa)
GAO33635.1Restriction endonuclease. (229 aa)
clpSATP-dependent Clp protease adapter protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (102 aa)
slmA_2Nucleoid occlusion factor SlmA. (204 aa)
rpmE50S ribosomal protein L31; Binds the 23S rRNA. (73 aa)
recNDNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (553 aa)
rarAReplication-associated recombination protein A. (438 aa)
ihfB_1Integration host factor subunit beta; Belongs to the bacterial histone-like protein family. (110 aa)
topADNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (824 aa)
parBPutative chromosome-partitioning protein ParB; Belongs to the ParB family. (278 aa)
slmA_1Nucleoid occlusion factor SlmA. (191 aa)
yvqKcob(I)yrinic acid a,c-diamide adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (181 aa)
GAO33022.1Flagellar protein YcgR. (229 aa)
fliRFlagellar biosynthetic protein FliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (262 aa)
fliQFlagellar biosynthetic protein FliQ; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (89 aa)
fliPFlagellar biosynthetic protein FliP precursor; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (248 aa)
fliOFlagellar protein FliO. (148 aa)
fliNFlagellar motor switch protein FliN. (153 aa)
fliMFlagellar motor switch protein FliM. (332 aa)
GAO32951.1Flagellar basal body-associated protein FliL; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family. (180 aa)
fliKFlagellar hook-length control protein. (367 aa)
fliJFlagellar FliJ protein. (152 aa)
fliHFlagellar assembly protein FliH. (211 aa)
fliGFlagellar motor switch protein FliG. (331 aa)
fliFFlagellar M-ring protein; The M ring may be actively involved in energy transduction. Belongs to the FliF family. (565 aa)
fliEFlagellar hook-basal body complex protein FliE. (108 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (492 aa)
GAO32834.1Nuclease-related domain protein. (320 aa)
rpsO30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
parCDNA topoisomerase 4 subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (808 aa)
parEDNA topoisomerase 4 subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (656 aa)
flgBFlagellar basal body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body. (135 aa)
flgCFlagellar basal-body rod protein FlgC; Belongs to the flagella basal body rod proteins family. (134 aa)
flgEFlagellar hook protein FlgE. (424 aa)
flgFFlagellar basal-body rod protein FlgF; Belongs to the flagella basal body rod proteins family. (247 aa)
flgGFlagellar basal-body rod protein FlgG; Belongs to the flagella basal body rod proteins family. (260 aa)
flgHFlagellar L-ring protein precursor; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (227 aa)
flgIFlagellar P-ring protein precursor; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (365 aa)
flgKFlagellar hook-associated protein 1. (645 aa)
flgLFlagellar hook-associated protein 3. (411 aa)
rpmF50S ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (59 aa)
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
rpmA50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (85 aa)
rpmI50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (65 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa)
rpmH50S ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (723 aa)
fisDNA-binding protein Fis; Belongs to the transcriptional regulatory Fis family. (87 aa)
rpsB30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (242 aa)
ycgRFlagellar brake protein YcgR; Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility. (252 aa)
GAO32362.1Flagellar hook-length control protein FliK. (337 aa)
fliDFlagellar hook-associated protein 2; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. (660 aa)
hag_2Flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (273 aa)
hag_1Flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (266 aa)
rplK50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (143 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (231 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (170 aa)
rplL50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (123 aa)
rpsL30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (124 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (214 aa)
rplD50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (207 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (105 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (275 aa)
rpsS30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (91 aa)
rplV50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (109 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (236 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (138 aa)
rpmC50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (63 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (87 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa)
rpsN30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rpsH30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rplF50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
rplR50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (118 aa)
rpsE30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (172 aa)
Your Current Organism:
Ferriphaselus amnicola
NCBI taxonomy Id: 1188319
Other names: DSM 26810, F. amnicola, Ferriphaselus amnicola Kato et al. 2014, JCM 18545, beta proteobacterium OYT1, strain OYT1
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