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| | JBW_00056 | KEGG: CysE, serine acetyltransferase; PFAM: transferase hexapeptide repeat containing protein; TIGRFAM: serine O-acetyltransferase. (222 aa) |
| | JBW_00521 | Threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; TIGRFAM: threonine dehydratase; KEGG: threonine dehydratase. (403 aa) |
| | JBW_00804 | Dehydratase, YjhG/YagF family; KEGG: dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; TIGRFAM: dehydratase, YjhG/YagF family; Belongs to the IlvD/Edd family. (661 aa) |
| | JBW_00805 | PFAM: Gluconate transporter; TIGRFAM: gluconate transporter; KEGG: gntP, H+:gluconate symporter. (447 aa) |
| | JBW_00806 | PFAM: dihydrodipicolinate synthetase; KEGG: pyruvate-dependent class I aldolase; Belongs to the DapA family. (298 aa) |
| | JBW_00811 | KEGG: dapB, dihydrodipicolinate reductase; PFAM: Dihydrodipicolinate reductase, C-terminal, dihydrodipicolinate reductase; TIGRFAM: dihydrodipicolinate reductase; Belongs to the DapB family. (255 aa) |
| | dsdA | HAMAP : D-serine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: D-serine dehydratase; TIGRFAM: D-serine ammonia-lyase; Belongs to the serine/threonine dehydratase family. DsdA subfamily. (451 aa) |
| | JBW_01008 | PFAM: aminotransferase class I and II; KEGG: class I and II aminotransferase. (387 aa) |
| | JBW_01093 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase type 1; KEGG: protein PabA. (191 aa) |
| | JBW_01094 | KEGG: para-aminobenzoate synthase component I; PFAM: Chorismate binding domain-containing protein, Anthranilate synthase component I domain protein; TIGRFAM: para-aminobenzoate synthase, subunit I. (466 aa) |
| | JBW_01177 | KEGG: cystathionine gamma-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (372 aa) |
| | JBW_01250 | PFAM: Orn/DAP/Arg decarboxylase 2, N-terminal, Orn/DAP/Arg decarboxylase 2, C-terminal; KEGG: diaminopimelate decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (422 aa) |
| | JBW_01307 | Methylglyoxal reductase (NADPH-dependent); KEGG: 2,5-diketo-D-gluconic acid reductase; PFAM: NADP-dependent oxidoreductase domain. (280 aa) |
| | JBW_01399 | TIGRFAM: threonine dehydratase; KEGG: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit, amino acid-binding ACT domain-containing protein. (411 aa) |
| | JBW_01677 | Phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: aroA, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, chorismate mutase-isozyme 3; PFAM: DAHP synthetase I/KDSA, Chorismate mutase, type II; SMART: Chorismate mutase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase, chorismate mutase. (358 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (250 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (180 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (355 aa) |
| | JBW_01803 | PFAM: DAHP synthetase I/KDSA; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I beta. (337 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa) |
| | trpF | KEGG: phosphoribosylanthranilate isomerase; HAMAP : N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5 phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (185 aa) |
| | JBW_01807 | KEGG: Indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase. (259 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (497 aa) |
| | JBW_01811 | KEGG: glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase type 1; TIGRFAM: glutamine amidotransferase of anthranilate synthase. (187 aa) |
| | pheA | PFAM: prephenate dehydratase, amino acid-binding ACT domain-containing protein; KEGG: prephenate dehydratase. (286 aa) |
| | JBW_01813 | KEGG: GCN5-like N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase. (152 aa) |
| | JBW_01831 | KEGG: L-serine dehydratase, beta subunit; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; PFAM: serine dehydratase beta chain, amino acid-binding ACT domain-containing protein. (220 aa) |
| | JBW_01832 | KEGG: L-serine ammonia-lyase; PFAM: serine dehydratase alpha chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit. (296 aa) |
| | JBW_01860 | Cystathionine beta-lyase; KEGG: aminotransferase class I and II; PFAM: aminotransferase class I and II. (399 aa) |
| | JBW_01912 | KEGG: chorismate mutase; TIGRFAM: chorismate mutase; PFAM: Chorismate mutase of the AroH class. (171 aa) |
| | JBW_01939 | KEGG: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; TIGRFAM: threonine synthase. (500 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (281 aa) |
| | aroK-2 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (176 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (366 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (413 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | JBW_02324 | Aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; KEGG: aspartate kinase; TIGRFAM: aspartate kinase, monofunctional class, aspartate kinase; Belongs to the aspartokinase family. (406 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (264 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (302 aa) |
| | JBW_02376 | KEGG: homoserine dehydrogenase; PFAM: homoserine dehydrogenase, homoserine dehydrogenase NAD-binding protein, amino acid-binding ACT domain-containing protein. (431 aa) |
| | JBW_02377 | KEGG: putative ACT domain-containing protein; HAMAP : UPF0735 ACT domain-containing protein; Belongs to the UPF0735 family. (148 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (433 aa) |
| | JBW_02720 | TIGRFAM: lysine-2,3-aminomutase, lysine 2,3-aminomutase YodO family protein; PFAM: Lysine-2,3-aminomutase, C-terminal domain, Radical SAM domain protein; KEGG: lysine 2,3-aminomutase YodO family protein. (426 aa) |
| | JBW_02820 | KEGG: Prephenate dehydrogenase; PFAM: Prephenate dehydrogenase. (293 aa) |
| | JBW_02821 | KEGG: phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA. (338 aa) |
| | JBW_02842 | PFAM: aminotransferase class I and II; KEGG: aspC, putative aspartate aminotransferase. (416 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (317 aa) |
| | JBW_02907 | PFAM: nitroreductase; KEGG: hypothetical protein; TIGRFAM: SagB-type dehydrogenase domain-containing protein. (245 aa) |
| | hisI | HAMAP : Phosphoribosyl-ATP pyrophosphatase, Phosphoribosyl-AMP cyclohydrolase, Histidine biosynthesis bifunctional protein hisIE; PFAM: phosphoribosyl-AMP cyclohydrolase, Phosphoribosyl-ATP pyrophosphohydrolase-like protein; KEGG: hisIE, putative phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP diphosphatase; In the N-terminal section; belongs to the PRA-CH family. (218 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-(5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; HAMAP : 1-(5-phosphoribosyl)-5-(5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. (242 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (202 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; HAMAP : Imidazoleglycerol-phosphate dehydratase; KEGG: imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; KEGG: hisC, putative histidinol-phosphate aminotransferase; HAMAP : Histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (352 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (449 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (221 aa) |
| | JBW_02916 | Glyoxylate reductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein, D-isomer specific 2-hydroxyacid dehydrogenase catalytic region-containing protein; KEGG: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein. (316 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (398 aa) |
| | JBW_02924 | PFAM: PHP domain protein; TIGRFAM: histidinol phosphate phosphatase HisJ family; KEGG: hisK, histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (256 aa) |
| | JBW_02928 | KEGG: cysteine synthase A; TIGRFAM: cysteine synthase A, cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (312 aa) |
| | JBW_02930 | KEGG: metC, cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (380 aa) |
| | JBW_02931 | KEGG: metB, cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (378 aa) |
| | JBW_03081 | PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: threonine aldolase. (344 aa) |
| | JBW_03147 | KEGG: aspartate/tyrosine/aromatic aminotransferase; PFAM: aminotransferase class I and II. (426 aa) |
| | JBW_03456 | KEGG: diaminopimelate decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2, N-terminal, Orn/DAP/Arg decarboxylase 2, C-terminal. (427 aa) |
| | JBW_03468 | KEGG: Glyoxalase/bleomycin resistance protein/dioxygenase; PFAM: Glyoxalase-like domain. (120 aa) |
| | JBW_03477 | TIGRFAM: aspartate kinase, monofunctional class, aspartate kinase; KEGG: putative aspartokinase; PFAM: aspartate/glutamate/uridylate kinase, amino acid-binding ACT domain-containing protein; Belongs to the aspartokinase family. (411 aa) |
| | JBW_03519 | Threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit, amino acid-binding ACT domain-containing protein; KEGG: L-threonine ammonia-lyase; TIGRFAM: threonine dehydratase. (402 aa) |
| | JBW_03544 | Cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: metC, cystathionine beta-lyase. (370 aa) |
| | JBW_03605 | Serine O-acetyltransferase; PFAM: transferase hexapeptide repeat containing protein; KEGG: serine O-acetyltransferase. (204 aa) |
| | JBW_03654 | Cystathionine beta-lyase; PFAM: aminotransferase class I and II; KEGG: cystathionine beta-lyase. (388 aa) |
| | JBW_03909 | Serine O-acetyltransferase; PFAM: transferase hexapeptide repeat containing protein; TIGRFAM: serine O-acetyltransferase; KEGG: cysE, serine acetyltransferase. (225 aa) |
| | JBW_04001 | Threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: putative threonine synthase. (330 aa) |
| | JBW_04230 | O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; KEGG: O-acetylhomoserine sulfhydrolase. (428 aa) |
| | JBW_04450 | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily. (410 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (304 aa) |
| | dapA-3 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (304 aa) |
| | dapA-4 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | dapB-2 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (272 aa) |
| | JBW_04760 | KEGG: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (288 aa) |
| | JBW_04761 | KEGG: Vitamin B12 dependent methionine synthase activation subunit; PFAM: Vitamin B12 dependent methionine synthase activation region. (226 aa) |
| | JBW_04762 | SMART: Methionine synthase B12-binding module cap domain protein; PFAM: homocysteine S-methyltransferase, dihydropteroate synthase DHPS, Methionine synthase B12-binding module cap domain protein, cobalamin B12-binding domain protein; KEGG: metH, methionine synthase. (795 aa) |
