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JBW_00062 JBW_00062 ilvD ilvD JBW_00549 JBW_00549 ilvC ilvC JBW_00553 JBW_00553 ilvE ilvE JBW_01095 JBW_01095 JBW_01161 JBW_01161 JBW_01162 JBW_01162 JBW_01789 JBW_01789 JBW_02073 JBW_02073 coaD coaD JBW_02530 JBW_02530 coaE coaE acpS acpS JBW_03783 JBW_03783 JBW_03827 JBW_03827 coaX coaX panD panD panC panC panB panB JBW_04259 JBW_04259
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
JBW_00062PFAM: 4'-phosphopantetheinyl transferase; KEGG: hypothetical protein; Belongs to the P-Pant transferase superfamily. (248 aa)
ilvDTIGRFAM: dihydroxy-acid dehydratase; KEGG: Dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; HAMAP : Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (550 aa)
JBW_00549PFAM: Acetolactate synthase, small subunit; KEGG: acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit. (181 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa)
JBW_00553Acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein, thiamine pyrophosphate central domain-containing protein; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; KEGG: acetolactate synthase, large subunit, biosynthetic type. (557 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (304 aa)
JBW_01095Aminodeoxychorismate lyase; PFAM: aminotransferase class IV; KEGG: ilvE, branched-chain amino acid aminotransferase. (292 aa)
JBW_01161KEGG: acetolactate synthase large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein, thiamine pyrophosphate central domain-containing protein. (566 aa)
JBW_01162TIGRFAM: acetolactate synthase, small subunit; KEGG: acetolactate synthase small subunit; PFAM: Acetolactate synthase, small subunit. (165 aa)
JBW_01789Acetolactate synthase; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein, thiamine pyrophosphate central domain-containing protein; KEGG: acetohydroxyacid synthase large subunit; Belongs to the TPP enzyme family. (587 aa)
JBW_02073Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (398 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
JBW_02530Dihydropyrimidinase; KEGG: D-hydantoinase; TIGRFAM: dihydropyrimidinase. (459 aa)
coaEDephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (204 aa)
acpSHolo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (125 aa)
JBW_037832-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (342 aa)
JBW_03827KEGG: branched chain amino acid aminotransferase; TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. (357 aa)
coaXPutative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (254 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (128 aa)
panCPantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (281 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (279 aa)
JBW_04259KEGG: dihydroxyacid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (545 aa)
Your Current Organism:
Pelosinus fermentans
NCBI taxonomy Id: 1192197
Other names: P. fermentans JBW45, Pelosinus fermentans JBW45, Pelosinus fermentans str. JBW45, Pelosinus fermentans strain JBW45
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