STRINGSTRING
mfd mfd uvrA uvrA clpA clpA hsdR_2 hsdR_2 cadA cadA EKJ88546.1 EKJ88546.1 EKJ88580.1 EKJ88580.1 EKJ88618.1 EKJ88618.1 secG secG dnaB dnaB ychF ychF EKJ88659.1 EKJ88659.1 mutL mutL EKJ86129.1 EKJ86129.1 EKJ87050.1 EKJ87050.1 EKJ87844.1 EKJ87844.1 mgtA mgtA EKJ88196.1 EKJ88196.1 EKJ87547.1 EKJ87547.1 recA recA EKJ87146.1 EKJ87146.1 EKJ88453.1 EKJ88453.1 hslU hslU groL groL groS groS EKJ87334.1 EKJ87334.1 EKJ86019.1 EKJ86019.1 EKJ86030.1 EKJ86030.1 EKJ85871.1 EKJ85871.1 hrpB hrpB EKJ86055.1 EKJ86055.1 EKJ86027.1 EKJ86027.1 EKJ85771.1 EKJ85771.1 EKJ85848.1 EKJ85848.1 EKJ85831.1 EKJ85831.1 EKJ85884.1 EKJ85884.1 EKJ86020.1 EKJ86020.1 recD recD EKJ86153.1 EKJ86153.1 EKJ86154.1 EKJ86154.1 EKJ86157.1 EKJ86157.1 gyrB gyrB soj soj EKJ86388.1 EKJ86388.1 EKJ87641.1 EKJ87641.1 dnaK dnaK EKJ88214.1 EKJ88214.1 secA secA hsdR_1 hsdR_1 EKJ87721.1 EKJ87721.1 EKJ87315.1 EKJ87315.1 EKJ86605.1 EKJ86605.1 ydcU ydcU clpC clpC EKJ87753.1 EKJ87753.1 EKJ86355.1 EKJ86355.1 hflB hflB EKJ87546.1 EKJ87546.1 EKJ86371.1 EKJ86371.1 gyrA gyrA recG recG EKJ87590.1 EKJ87590.1 EKJ87451.1 EKJ87451.1 ruvB ruvB EKJ87393.1 EKJ87393.1 EKJ87966.1 EKJ87966.1 EKJ87470.1 EKJ87470.1 radA radA atpA atpA atpD atpD mutS mutS uvrB uvrB lon lon EKJ87286.1 EKJ87286.1 EKJ86789.1 EKJ86789.1 EKJ88295.1 EKJ88295.1 clpP clpP clpX clpX rho rho EKJ85214.1 EKJ85214.1 cysA cysA cysW cysW cysT cysT kdpA kdpA kdpB kdpB kdpC kdpC EKJ84867.1 EKJ84867.1 EKJ85148.1 EKJ85148.1 EKJ85563.1 EKJ85563.1 secD secD secF secF smc smc ruvA ruvA EKJ85068.1 EKJ85068.1 EKJ85619.1 EKJ85619.1 priA priA clpP-2 clpP-2 EKJ85191.1 EKJ85191.1 EKJ85650.1 EKJ85650.1 EKJ88163.1 EKJ88163.1 EKJ85082.1 EKJ85082.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1140 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (963 aa)
clpAATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. (755 aa)
hsdR_2Type I site-specific deoxyribonuclease, HsdR family; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1009 aa)
cadACadmium-exporting ATPase. (671 aa)
EKJ88546.1PF01883 domain protein. (107 aa)
EKJ88580.1ABC transporter, ATP-binding protein. (426 aa)
EKJ88618.1Putative ATP-dependent helicase PcrA. (678 aa)
secGPreprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (110 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (427 aa)
ychFGTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (365 aa)
EKJ88659.1DEAD/DEAH box helicase; Belongs to the DEAD box helicase family. (536 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (610 aa)
EKJ86129.1AAA domain protein. (498 aa)
EKJ87050.1ABC transporter, ATP-binding protein. (283 aa)
EKJ87844.1ATP-dependent DNA helicase, RecQ family. (484 aa)
mgtAMagnesium-importing ATPase. (777 aa)
EKJ88196.1Putative calcium-translocating P-type ATPase, PMCA-type. (836 aa)
EKJ87547.1ATPase, AAA family; Belongs to the ClpA/ClpB family. (795 aa)
recARecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (387 aa)
EKJ87146.1ABC transporter transmembrane region 2. (567 aa)
EKJ88453.1Hypothetical protein. (427 aa)
hslUATP-dependent protease HslVU, ATPase subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (472 aa)
groLChaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (548 aa)
groSChaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (96 aa)
EKJ87334.1ABC transporter, ATP-binding protein. (600 aa)
EKJ86019.1E1-E2 ATPase. (896 aa)
EKJ86030.1PF11074 domain protein. (676 aa)
EKJ85871.1ATPase, AAA family. (786 aa)
hrpBATP-dependent helicase HrpB. (821 aa)
EKJ86055.1Copper-exporting ATPase. (820 aa)
EKJ86027.1CobQ/CobB/MinD/ParA nucleotide binding domain protein. (308 aa)
EKJ85771.1ATPase, AAA family. (298 aa)
EKJ85848.1Hsp90 protein. (610 aa)
EKJ85831.1YhjQ protein. (250 aa)
EKJ85884.1DEAD/DEAH box helicase; Belongs to the DEAD box helicase family. (528 aa)
EKJ86020.1Putative exodeoxyribonuclease V, beta subunit. (1203 aa)
recDExodeoxyribonuclease V, alpha subunit. (597 aa)
EKJ86153.1GHKL domain protein. (585 aa)
EKJ86154.1DEAD/DEAH box helicase. (957 aa)
EKJ86157.1ATPase MipZ. (290 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (610 aa)
sojSporulation initiation inhibitor protein Soj. (253 aa)
EKJ86388.1Putative ABC transporter, permease/ATP-binding protein. (607 aa)
EKJ87641.1Type III restriction enzyme, res subunit. (947 aa)
dnaKChaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (644 aa)
EKJ88214.1CbbQ/NirQ/NorQ C-terminal domain protein. (260 aa)
secAPreprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (918 aa)
hsdR_1Type I site-specific deoxyribonuclease, HsdR family; Subunit R is required for both nuclease and ATPase activities, but not for modification. (987 aa)
EKJ87721.1DEAD/DEAH box helicase; Belongs to the DEAD box helicase family. (471 aa)
EKJ87315.1Copper-exporting ATPase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. (734 aa)
EKJ86605.1Polyamine ABC transporter, ATP-binding protein; Belongs to the ABC transporter superfamily. (341 aa)
ydcUABC transporter, permease protein YdcU. (305 aa)
clpCNegative regulator of genetic competence ClpC/MecB; Belongs to the ClpA/ClpB family. (850 aa)
EKJ87753.1ABC transporter transmembrane region. (631 aa)
EKJ86355.1ABC transporter transmembrane region. (742 aa)
hflBATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (650 aa)
EKJ87546.1ATP-dependent DNA helicase, RecQ family. (635 aa)
EKJ86371.1MutS domain V protein. (507 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (841 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (689 aa)
EKJ87590.1TonB-dependent receptor. (689 aa)
EKJ87451.1ABC-2 family transporter protein. (243 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (341 aa)
EKJ87393.1PF11074 domain protein. (501 aa)
EKJ87966.1DNA gyrase/topoisomerase IV, A subunit. (456 aa)
EKJ87470.1DNA topoisomerase II, N-terminal domain protein. (708 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (455 aa)
atpAATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (504 aa)
atpDATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (468 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. (840 aa)
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (664 aa)
lonEndopeptidase La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (790 aa)
EKJ87286.1Multidrug export ATP-binding/permease protein SAV1866 family protein. (617 aa)
EKJ86789.1ABC transporter, ATP-binding protein. (399 aa)
EKJ88295.1ATPase FliI/YscN family. (454 aa)
clpPATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (200 aa)
clpXATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (426 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (467 aa)
EKJ85214.1Putative ATP-dependent Clp endopeptidase, proteolytic subunit ClpP. (186 aa)
cysASulfate ABC transporter, ATP-binding protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (354 aa)
cysWSulfate ABC transporter, permease protein CysW. (271 aa)
cysTSulfate ABC transporter, permease protein CysT; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (275 aa)
kdpAK+-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (545 aa)
kdpBK+-transporting ATPase, B subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (684 aa)
kdpCPutative K+-transporting ATPase, C subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (192 aa)
EKJ84867.1Smr domain protein. (91 aa)
EKJ85148.1Recombination factor protein RarA. (419 aa)
EKJ85563.1AAA domain protein. (608 aa)
secDExport membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (644 aa)
secFExport membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (312 aa)
smcRecF/RecN/SMC N-terminal domain protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (927 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (199 aa)
EKJ85068.1Holliday junction DNA helicase RuvB, N-terminal domain protein; Belongs to the AAA ATPase family. (419 aa)
EKJ85619.1Putative ATP-dependent DNA helicase PcrA. (727 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (650 aa)
clpP-2Putative ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (202 aa)
EKJ85191.1Helicase C-terminal domain protein. (662 aa)
EKJ85650.1UvrD/REP helicase N-terminal domain protein. (662 aa)
EKJ88163.1Type III restriction enzyme, res subunit. (565 aa)
EKJ85082.1ATPase, AAA family. (262 aa)
Your Current Organism:
Leptospira meyeri
NCBI taxonomy Id: 1193051
Other names: L. meyeri serovar Hardjo str. Went 5, Leptospira meyeri serovar Hardjo str. Went 5
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