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| | CHR53_16050 | Unannotated protein. (729 aa) |
| | purU | Unannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (299 aa) |
| | lpdA | Unannotated protein. (466 aa) |
| | glyA | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa) |
| | mdh | Unannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (315 aa) |
| | CHR53_16745 | Unannotated protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (217 aa) |
| | CHR53_16755 | Unannotated protein. (508 aa) |
| | mdh-2 | Unannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (316 aa) |
| | CHR53_16865 | Unannotated protein. (261 aa) |
| | CHR53_16875 | Unannotated protein. (491 aa) |
| | CHR53_17175 | Unannotated protein. (672 aa) |
| | CHR53_17195 | Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (78 aa) |
| | CHR53_17285 | Unannotated protein. (222 aa) |
| | CHR53_18000 | Unannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (422 aa) |
| | odhA | Unannotated protein; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (941 aa) |
| | CHR53_18340 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (163 aa) |
| | thyA | Unannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | fhs | Unannotated protein; Belongs to the formate--tetrahydrofolate ligase family. (562 aa) |
| | CHR53_18690 | Unannotated protein. (396 aa) |
| | CHR53_18990 | Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (425 aa) |
| | dinB | Unannotated protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (425 aa) |
| | CHR53_19345 | Unannotated protein. (373 aa) |
| | CHR53_19350 | Unannotated protein. (515 aa) |
| | mce | Unannotated protein. (137 aa) |
| | CHR53_19360 | Unannotated protein. (170 aa) |
| | CHR53_19385 | Unannotated protein. (439 aa) |
| | CHR53_19390 | Unannotated protein. (371 aa) |
| | CHR53_19395 | Unannotated protein. (732 aa) |
| | CHR53_19400 | Unannotated protein. (611 aa) |
| | CHR53_19405 | Unannotated protein. (436 aa) |
| | CHR53_19410 | Unannotated protein. (327 aa) |
| | CHR53_19415 | Unannotated protein. (330 aa) |
| | lpdA-2 | Unannotated protein. (473 aa) |
| | buk | Unannotated protein; Belongs to the acetokinase family. (367 aa) |
| | CHR53_19430 | Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (367 aa) |
| | CHR53_19435 | Unannotated protein. (306 aa) |
| | folD | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | accC | Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | accB | Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (167 aa) |
| | lipM | Unannotated protein; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. (278 aa) |
| | gcvPB | Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (485 aa) |
| | gcvPA | Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (454 aa) |
| | gcvT | Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. (366 aa) |
| | ldh | Unannotated protein; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (318 aa) |
| | CHR53_20470 | Unannotated protein. (429 aa) |
| | CHR53_20475 | Unannotated protein. (338 aa) |
| | pdhA | Unannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (366 aa) |
| | CHR53_20830 | Unannotated protein; Belongs to the folylpolyglutamate synthase family. (440 aa) |
| | murI | Unannotated protein; Provides the (R)-glutamate required for cell wall biosynthesis. (266 aa) |
| | CHR53_20980 | Unannotated protein. (253 aa) |
| | CHR53_20985 | Unannotated protein. (583 aa) |
| | CHR53_20990 | Unannotated protein. (202 aa) |
| | mdh-3 | Unannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (312 aa) |
| | CHR53_21230 | Unannotated protein. (422 aa) |
| | CHR53_21235 | Unannotated protein; Belongs to the citrate synthase family. (373 aa) |
| | accA | Unannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa) |
| | accD | Unannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (292 aa) |
| | CHR53_21270 | Unannotated protein. (412 aa) |
| | ackA | Unannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa) |
| | CHR53_21395 | Unannotated protein. (527 aa) |
| | CHR53_21450 | Unannotated protein. (573 aa) |
| | pckA | Unannotated protein; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (528 aa) |
| | CHR53_22155 | Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (429 aa) |
| | CHR53_22295 | Unannotated protein. (329 aa) |
| | lipA | Unannotated protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (307 aa) |
| | gcvH | Unannotated protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. (127 aa) |
| | ilvB | Unannotated protein. (567 aa) |
| | CHR53_24240 | Unannotated protein; Belongs to the glutamate synthase family. (470 aa) |
| | CHR53_24245 | Unannotated protein; Belongs to the glutamate synthase family. (473 aa) |
| | CHR53_24465 | Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (316 aa) |
| | CHR53_25220 | Unannotated protein. (316 aa) |
| | glsA | Unannotated protein; Belongs to the glutaminase family. (327 aa) |
| | CHR53_25945 | Unannotated protein. (265 aa) |
| | CHR53_26135 | Unannotated protein; Belongs to the TPP enzyme family. (544 aa) |
| | glyA-2 | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa) |
| | icmF | Unannotated protein; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1083 aa) |
| | lipL | Unannotated protein; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. (284 aa) |
| | pta | Unannotated protein. (323 aa) |
| | CHR53_27625 | Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (460 aa) |
| | mqo | Unannotated protein. (511 aa) |
| | glmS | Unannotated protein; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (600 aa) |
| | CHR53_01280 | Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (430 aa) |
| | CHR53_02145 | Unannotated protein; Belongs to the TPP enzyme family. (557 aa) |
| | CHR53_02155 | Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (391 aa) |
| | CHR53_02275 | Unannotated protein. (362 aa) |
| | CHR53_03170 | Unannotated protein. (504 aa) |
| | CHR53_03675 | Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (462 aa) |
| | CHR53_03680 | Unannotated protein. (521 aa) |
| | CHR53_03730 | Unannotated protein. (524 aa) |
| | CHR53_03735 | Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (462 aa) |
| | CHR53_03875 | Unannotated protein; Belongs to the TPP enzyme family. (547 aa) |
| | CHR53_04060 | Unannotated protein. (360 aa) |
| | CHR53_04065 | Unannotated protein. (393 aa) |
| | CHR53_04725 | Unannotated protein; Belongs to the LDH/MDH superfamily. (324 aa) |
| | CHR53_04920 | Unannotated protein; Belongs to the glutamate synthase family. (531 aa) |
| | CHR53_04965 | Unannotated protein. (458 aa) |
| | CHR53_05560 | Unannotated protein. (123 aa) |
| | leuD | Unannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (194 aa) |
| | leuC | Unannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (472 aa) |
| | leuB | Unannotated protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (368 aa) |
| | leuA | Unannotated protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (513 aa) |
| | ilvC | Unannotated protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (343 aa) |
| | CHR53_05755 | Unannotated protein. (173 aa) |
| | ilvB-2 | Unannotated protein. (575 aa) |
| | ilvD | Unannotated protein; Belongs to the IlvD/Edd family. (555 aa) |
| | CHR53_06200 | Unannotated protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (516 aa) |
| | CHR53_06310 | Unannotated protein. (372 aa) |
| | fumC | Unannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (459 aa) |
| | CHR53_07955 | Unannotated protein. (329 aa) |
| | CHR53_08510 | Unannotated protein. (389 aa) |
| | CHR53_08630 | Unannotated protein. (337 aa) |
| | CHR53_08635 | Unannotated protein. (764 aa) |
| | pdhA-2 | Unannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (371 aa) |
| | CHR53_08895 | Unannotated protein. (325 aa) |
| | CHR53_08900 | Unannotated protein. (440 aa) |
| | lpdA-3 | Unannotated protein. (471 aa) |
| | pyc | Unannotated protein; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1147 aa) |
| | CHR53_09160 | Unannotated protein. (445 aa) |
| | CHR53_09165 | Unannotated protein. (70 aa) |
| | CHR53_09170 | Unannotated protein. (513 aa) |
| | sucC | Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa) |
| | sucD | Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa) |
| | CHR53_09920 | Unannotated protein. (578 aa) |
| | CHR53_09925 | Unannotated protein. (288 aa) |
| | glnA | Unannotated protein. (444 aa) |
| | CHR53_11750 | Unannotated protein. (340 aa) |
| | glsA-2 | Unannotated protein; Belongs to the glutaminase family. (309 aa) |
| | CHR53_12330 | Unannotated protein; Belongs to the IlvD/Edd family. (735 aa) |
| | ilvA | Unannotated protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (421 aa) |
| | CHR53_12555 | Unannotated protein. (205 aa) |
| | CHR53_12745 | Unannotated protein. (396 aa) |
| | CHR53_12750 | Unannotated protein. (320 aa) |
| | acnA | Unannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (901 aa) |
| | CHR53_13590 | Unannotated protein; Belongs to the TPP enzyme family. (528 aa) |
| | CHR53_13650 | Unannotated protein. (765 aa) |
| | CHR53_13910 | Unannotated protein. (1494 aa) |
| | lpdA-4 | Unannotated protein. (460 aa) |
| | CHR53_13930 | Unannotated protein. (438 aa) |
| | CHR53_13935 | Unannotated protein. (326 aa) |
| | CHR53_13940 | Unannotated protein. (329 aa) |
| | sucD-2 | Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa) |
| | CHR53_14035 | Unannotated protein. (374 aa) |
| | CHR53_14260 | Unannotated protein; Belongs to the TPP enzyme family. (553 aa) |
| | CHR53_15130 | Unannotated protein. (117 aa) |
| | CHR53_15815 | Unannotated protein. (499 aa) |
| | CHR53_15850 | Unannotated protein. (379 aa) |
