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| | CHR53_16050 | Unannotated protein. (729 aa) |
| | purU | Unannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (299 aa) |
| | lpdA | Unannotated protein. (466 aa) |
| | glyA | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa) |
| | mdh | Unannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (315 aa) |
| | CHR53_16745 | Unannotated protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (217 aa) |
| | CHR53_16755 | Unannotated protein. (508 aa) |
| | mdh-2 | Unannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (316 aa) |
| | CHR53_16865 | Unannotated protein. (261 aa) |
| | CHR53_16875 | Unannotated protein. (491 aa) |
| | CHR53_17175 | Unannotated protein. (672 aa) |
| | CHR53_17195 | Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (78 aa) |
| | CHR53_17285 | Unannotated protein. (222 aa) |
| | CHR53_18000 | Unannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (422 aa) |
| | odhA | Unannotated protein; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (941 aa) |
| | CHR53_18340 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (163 aa) |
| | thyA | Unannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | fhs | Unannotated protein; Belongs to the formate--tetrahydrofolate ligase family. (562 aa) |
| | CHR53_18690 | Unannotated protein. (396 aa) |
| | CHR53_18990 | Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (425 aa) |
| | CHR53_19405 | Unannotated protein. (436 aa) |
| | CHR53_19410 | Unannotated protein. (327 aa) |
| | CHR53_19415 | Unannotated protein. (330 aa) |
| | lpdA-2 | Unannotated protein. (473 aa) |
| | buk | Unannotated protein; Belongs to the acetokinase family. (367 aa) |
| | CHR53_19430 | Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (367 aa) |
| | CHR53_19435 | Unannotated protein. (306 aa) |
| | folD | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | accC | Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | accB | Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (167 aa) |
| | lipM | Unannotated protein; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. (278 aa) |
| | gcvPB | Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (485 aa) |
| | gcvPA | Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (454 aa) |
| | gcvT | Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. (366 aa) |
| | ldh | Unannotated protein; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (318 aa) |
| | CHR53_20470 | Unannotated protein. (429 aa) |
| | CHR53_20475 | Unannotated protein. (338 aa) |
| | pdhA | Unannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (366 aa) |
| | CHR53_20830 | Unannotated protein; Belongs to the folylpolyglutamate synthase family. (440 aa) |
| | murI | Unannotated protein; Provides the (R)-glutamate required for cell wall biosynthesis. (266 aa) |
| | CHR53_20980 | Unannotated protein. (253 aa) |
| | CHR53_20985 | Unannotated protein. (583 aa) |
| | CHR53_20990 | Unannotated protein. (202 aa) |
| | mdh-3 | Unannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (312 aa) |
| | CHR53_21230 | Unannotated protein. (422 aa) |
| | CHR53_21235 | Unannotated protein; Belongs to the citrate synthase family. (373 aa) |
| | accA | Unannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa) |
| | accD | Unannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (292 aa) |
| | CHR53_21270 | Unannotated protein. (412 aa) |
| | ackA | Unannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa) |
| | CHR53_21395 | Unannotated protein. (527 aa) |
| | CHR53_21450 | Unannotated protein. (573 aa) |
| | pckA | Unannotated protein; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (528 aa) |
| | CHR53_22155 | Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (429 aa) |
| | CHR53_22295 | Unannotated protein. (329 aa) |
| | lipA | Unannotated protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (307 aa) |
| | gcvH | Unannotated protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. (127 aa) |
| | ilvB | Unannotated protein. (567 aa) |
| | CHR53_24240 | Unannotated protein; Belongs to the glutamate synthase family. (470 aa) |
| | CHR53_24245 | Unannotated protein; Belongs to the glutamate synthase family. (473 aa) |
| | CHR53_24465 | Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (316 aa) |
| | CHR53_25220 | Unannotated protein. (316 aa) |
| | glsA | Unannotated protein; Belongs to the glutaminase family. (327 aa) |
| | CHR53_25945 | Unannotated protein. (265 aa) |
| | CHR53_26135 | Unannotated protein; Belongs to the TPP enzyme family. (544 aa) |
| | glyA-2 | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa) |
| | lipL | Unannotated protein; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. (284 aa) |
| | pta | Unannotated protein. (323 aa) |
| | CHR53_27625 | Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (460 aa) |
| | mqo | Unannotated protein. (511 aa) |
| | glmS | Unannotated protein; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (600 aa) |
| | CHR53_01280 | Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (430 aa) |
| | CHR53_02145 | Unannotated protein; Belongs to the TPP enzyme family. (557 aa) |
| | CHR53_02155 | Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (391 aa) |
| | CHR53_02275 | Unannotated protein. (362 aa) |
| | CHR53_03170 | Unannotated protein. (504 aa) |
| | CHR53_03675 | Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (462 aa) |
| | CHR53_03680 | Unannotated protein. (521 aa) |
| | CHR53_03730 | Unannotated protein. (524 aa) |
| | CHR53_03735 | Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (462 aa) |
| | CHR53_03875 | Unannotated protein; Belongs to the TPP enzyme family. (547 aa) |
| | CHR53_04060 | Unannotated protein. (360 aa) |
| | CHR53_04065 | Unannotated protein. (393 aa) |
| | CHR53_04725 | Unannotated protein; Belongs to the LDH/MDH superfamily. (324 aa) |
| | CHR53_04920 | Unannotated protein; Belongs to the glutamate synthase family. (531 aa) |
| | CHR53_04965 | Unannotated protein. (458 aa) |
| | leuD | Unannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (194 aa) |
| | leuC | Unannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (472 aa) |
| | leuB | Unannotated protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (368 aa) |
| | leuA | Unannotated protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (513 aa) |
| | ilvC | Unannotated protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (343 aa) |
| | CHR53_05755 | Unannotated protein. (173 aa) |
| | ilvB-2 | Unannotated protein. (575 aa) |
| | ilvD | Unannotated protein; Belongs to the IlvD/Edd family. (555 aa) |
| | CHR53_06200 | Unannotated protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (516 aa) |
| | CHR53_06310 | Unannotated protein. (372 aa) |
| | fumC | Unannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (459 aa) |
| | CHR53_07955 | Unannotated protein. (329 aa) |
| | CHR53_08510 | Unannotated protein. (389 aa) |
| | CHR53_08630 | Unannotated protein. (337 aa) |
| | CHR53_08635 | Unannotated protein. (764 aa) |
| | pdhA-2 | Unannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (371 aa) |
| | CHR53_08895 | Unannotated protein. (325 aa) |
| | CHR53_08900 | Unannotated protein. (440 aa) |
| | lpdA-3 | Unannotated protein. (471 aa) |
| | pyc | Unannotated protein; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1147 aa) |
| | CHR53_09160 | Unannotated protein. (445 aa) |
| | CHR53_09165 | Unannotated protein. (70 aa) |
| | CHR53_09170 | Unannotated protein. (513 aa) |
| | sucC | Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa) |
| | sucD | Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa) |
| | CHR53_09920 | Unannotated protein. (578 aa) |
| | CHR53_09925 | Unannotated protein. (288 aa) |
| | glnA | Unannotated protein. (444 aa) |
| | CHR53_11750 | Unannotated protein. (340 aa) |
| | glsA-2 | Unannotated protein; Belongs to the glutaminase family. (309 aa) |
| | CHR53_12330 | Unannotated protein; Belongs to the IlvD/Edd family. (735 aa) |
| | ilvA | Unannotated protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (421 aa) |
| | CHR53_12555 | Unannotated protein. (205 aa) |
| | CHR53_12745 | Unannotated protein. (396 aa) |
| | CHR53_12750 | Unannotated protein. (320 aa) |
| | acnA | Unannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (901 aa) |
| | CHR53_13590 | Unannotated protein; Belongs to the TPP enzyme family. (528 aa) |
| | CHR53_13650 | Unannotated protein. (765 aa) |
| | CHR53_13910 | Unannotated protein. (1494 aa) |
| | lpdA-4 | Unannotated protein. (460 aa) |
| | CHR53_13930 | Unannotated protein. (438 aa) |
| | CHR53_13935 | Unannotated protein. (326 aa) |
| | CHR53_13940 | Unannotated protein. (329 aa) |
| | sucD-2 | Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa) |
| | CHR53_14035 | Unannotated protein. (374 aa) |
| | CHR53_14260 | Unannotated protein; Belongs to the TPP enzyme family. (553 aa) |
| | CHR53_15130 | Unannotated protein. (117 aa) |
| | CHR53_15815 | Unannotated protein. (499 aa) |
| | CHR53_15850 | Unannotated protein. (379 aa) |
