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CHR53_16050 CHR53_16050 lpdA lpdA CHR53_16745 CHR53_16745 CHR53_16755 CHR53_16755 CHR53_16865 CHR53_16865 CHR53_16875 CHR53_16875 CHR53_17195 CHR53_17195 CHR53_17285 CHR53_17285 CHR53_18000 CHR53_18000 odhA odhA CHR53_19405 CHR53_19405 CHR53_19410 CHR53_19410 CHR53_19415 CHR53_19415 lpdA-2 lpdA-2 buk buk CHR53_19430 CHR53_19430 CHR53_19435 CHR53_19435 accC accC accB accB lipM lipM ldh ldh CHR53_20470 CHR53_20470 CHR53_20475 CHR53_20475 pdhA pdhA CHR53_20980 CHR53_20980 CHR53_20985 CHR53_20985 CHR53_20990 CHR53_20990 CHR53_21230 CHR53_21230 CHR53_21235 CHR53_21235 accA accA accD accD CHR53_21270 CHR53_21270 ackA ackA CHR53_21395 CHR53_21395 CHR53_21450 CHR53_21450 lipA lipA ilvB ilvB CHR53_25220 CHR53_25220 CHR53_26135 CHR53_26135 lipL lipL pta pta CHR53_02145 CHR53_02145 CHR53_02275 CHR53_02275 CHR53_03170 CHR53_03170 CHR53_03875 CHR53_03875 CHR53_04060 CHR53_04060 CHR53_04725 CHR53_04725 CHR53_04965 CHR53_04965 leuD leuD leuC leuC leuB leuB leuA leuA ilvC ilvC CHR53_05755 CHR53_05755 ilvB-2 ilvB-2 ilvD ilvD CHR53_06200 CHR53_06200 CHR53_06310 CHR53_06310 fumC fumC CHR53_07955 CHR53_07955 CHR53_08630 CHR53_08630 CHR53_08635 CHR53_08635 pdhA-2 pdhA-2 CHR53_08895 CHR53_08895 CHR53_08900 CHR53_08900 lpdA-3 lpdA-3 pyc pyc CHR53_09160 CHR53_09160 CHR53_09165 CHR53_09165 CHR53_09170 CHR53_09170 sucC sucC sucD sucD CHR53_09920 CHR53_09920 CHR53_09925 CHR53_09925 CHR53_12330 CHR53_12330 ilvA ilvA CHR53_12555 CHR53_12555 acnA acnA CHR53_13590 CHR53_13590 lpdA-4 lpdA-4 CHR53_13930 CHR53_13930 CHR53_13935 CHR53_13935 CHR53_13940 CHR53_13940 sucD-2 sucD-2 CHR53_14035 CHR53_14035 CHR53_14260 CHR53_14260 CHR53_15130 CHR53_15130 CHR53_15815 CHR53_15815
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHR53_16050Unannotated protein. (729 aa)
lpdAUnannotated protein. (466 aa)
CHR53_16745Unannotated protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (217 aa)
CHR53_16755Unannotated protein. (508 aa)
CHR53_16865Unannotated protein. (261 aa)
CHR53_16875Unannotated protein. (491 aa)
CHR53_17195Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (78 aa)
CHR53_17285Unannotated protein. (222 aa)
CHR53_18000Unannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (422 aa)
odhAUnannotated protein; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (941 aa)
CHR53_19405Unannotated protein. (436 aa)
CHR53_19410Unannotated protein. (327 aa)
CHR53_19415Unannotated protein. (330 aa)
lpdA-2Unannotated protein. (473 aa)
bukUnannotated protein; Belongs to the acetokinase family. (367 aa)
CHR53_19430Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (367 aa)
CHR53_19435Unannotated protein. (306 aa)
accCUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
accBUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (167 aa)
lipMUnannotated protein; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. (278 aa)
ldhUnannotated protein; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (318 aa)
CHR53_20470Unannotated protein. (429 aa)
CHR53_20475Unannotated protein. (338 aa)
pdhAUnannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (366 aa)
CHR53_20980Unannotated protein. (253 aa)
CHR53_20985Unannotated protein. (583 aa)
CHR53_20990Unannotated protein. (202 aa)
CHR53_21230Unannotated protein. (422 aa)
CHR53_21235Unannotated protein; Belongs to the citrate synthase family. (373 aa)
accAUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa)
accDUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (292 aa)
CHR53_21270Unannotated protein. (412 aa)
ackAUnannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
CHR53_21395Unannotated protein. (527 aa)
CHR53_21450Unannotated protein. (573 aa)
lipAUnannotated protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (307 aa)
ilvBUnannotated protein. (567 aa)
CHR53_25220Unannotated protein. (316 aa)
CHR53_26135Unannotated protein; Belongs to the TPP enzyme family. (544 aa)
lipLUnannotated protein; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. (284 aa)
ptaUnannotated protein. (323 aa)
CHR53_02145Unannotated protein; Belongs to the TPP enzyme family. (557 aa)
CHR53_02275Unannotated protein. (362 aa)
CHR53_03170Unannotated protein. (504 aa)
CHR53_03875Unannotated protein; Belongs to the TPP enzyme family. (547 aa)
CHR53_04060Unannotated protein. (360 aa)
CHR53_04725Unannotated protein; Belongs to the LDH/MDH superfamily. (324 aa)
CHR53_04965Unannotated protein. (458 aa)
leuDUnannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (194 aa)
leuCUnannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (472 aa)
leuBUnannotated protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (368 aa)
leuAUnannotated protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (513 aa)
ilvCUnannotated protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (343 aa)
CHR53_05755Unannotated protein. (173 aa)
ilvB-2Unannotated protein. (575 aa)
ilvDUnannotated protein; Belongs to the IlvD/Edd family. (555 aa)
CHR53_06200Unannotated protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (516 aa)
CHR53_06310Unannotated protein. (372 aa)
fumCUnannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (459 aa)
CHR53_07955Unannotated protein. (329 aa)
CHR53_08630Unannotated protein. (337 aa)
CHR53_08635Unannotated protein. (764 aa)
pdhA-2Unannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (371 aa)
CHR53_08895Unannotated protein. (325 aa)
CHR53_08900Unannotated protein. (440 aa)
lpdA-3Unannotated protein. (471 aa)
pycUnannotated protein; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1147 aa)
CHR53_09160Unannotated protein. (445 aa)
CHR53_09165Unannotated protein. (70 aa)
CHR53_09170Unannotated protein. (513 aa)
sucCUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
sucDUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
CHR53_09920Unannotated protein. (578 aa)
CHR53_09925Unannotated protein. (288 aa)
CHR53_12330Unannotated protein; Belongs to the IlvD/Edd family. (735 aa)
ilvAUnannotated protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (421 aa)
CHR53_12555Unannotated protein. (205 aa)
acnAUnannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (901 aa)
CHR53_13590Unannotated protein; Belongs to the TPP enzyme family. (528 aa)
lpdA-4Unannotated protein. (460 aa)
CHR53_13930Unannotated protein. (438 aa)
CHR53_13935Unannotated protein. (326 aa)
CHR53_13940Unannotated protein. (329 aa)
sucD-2Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)
CHR53_14035Unannotated protein. (374 aa)
CHR53_14260Unannotated protein; Belongs to the TPP enzyme family. (553 aa)
CHR53_15130Unannotated protein. (117 aa)
CHR53_15815Unannotated protein. (499 aa)
Your Current Organism:
Bacillus mesonae
NCBI taxonomy Id: 1193713
Other names: B. mesonae, Bacillus mesonae Liu et al. 2014, Bacillus sp. FJAT-13985, CGMCC1.12238, DSM 25968, strain FJAT-13985
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