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guaC guaC CHR53_17240 CHR53_17240 CHR53_17245 CHR53_17245 deoD deoD deoA deoA deoB deoB CHR53_20040 CHR53_20040 CHR53_20185 CHR53_20185 udk udk apt apt dut dut CHR53_22185 CHR53_22185 CHR53_22710 CHR53_22710 CHR53_23770 CHR53_23770 CHR53_24000 CHR53_24000 CHR53_25105 CHR53_25105 deoC deoC deoA-2 deoA-2 deoD-2 deoD-2 CHR53_25560 CHR53_25560 deoD-3 deoD-3 upp upp tdk tdk purA purA guaB guaB tmk tmk tilS tilS hpt hpt ftsH ftsH guaA guaA CHR53_02320 CHR53_02320 purE purE purK purK CHR53_02390 CHR53_02390 purC purC purS purS purQ purQ purL purL purF purF purM purM purN purN purH purH purD purD CHR53_03305 CHR53_03305 CHR53_03485 CHR53_03485 CHR53_04085 CHR53_04085 CHR53_04875 CHR53_04875 CHR53_06305 CHR53_06305 carA carA carB carB argF argF deoC-2 deoC-2 pyrR pyrR CHR53_09355 CHR53_09355 pyrB pyrB pyrC pyrC carA-2 carA-2 carB-2 carB-2 pyrK pyrK pyrD pyrD pyrF pyrF pyrE pyrE guaD guaD CHR53_12730 CHR53_12730 xpt xpt CHR53_12900 CHR53_12900 CHR53_12940 CHR53_12940 allB allB CHR53_13090 CHR53_13090 CHR53_13305 CHR53_13305 CHR53_13310 CHR53_13310 hydA hydA CHR53_13320 CHR53_13320 CHR53_13325 CHR53_13325 CHR53_13480 CHR53_13480 CHR53_14375 CHR53_14375 CHR53_14380 CHR53_14380
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
guaCUnannotated protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (327 aa)
CHR53_17240Unannotated protein. (324 aa)
CHR53_17245Unannotated protein. (446 aa)
deoDUnannotated protein. (234 aa)
deoAUnannotated protein. (435 aa)
deoBUnannotated protein; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (394 aa)
CHR53_20040Unannotated protein; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (133 aa)
CHR53_20185Unannotated protein. (153 aa)
udkUnannotated protein. (210 aa)
aptUnannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
dutUnannotated protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (145 aa)
CHR53_22185Unannotated protein. (441 aa)
CHR53_22710Unannotated protein; Belongs to the 5'-nucleotidase family. (448 aa)
CHR53_23770Unannotated protein; Belongs to the 5'-nucleotidase family. (624 aa)
CHR53_24000Unannotated protein. (1179 aa)
CHR53_25105Unannotated protein; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (132 aa)
deoCUnannotated protein; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (224 aa)
deoA-2Unannotated protein. (433 aa)
deoD-2Unannotated protein. (233 aa)
CHR53_25560Unannotated protein. (410 aa)
deoD-3Unannotated protein. (237 aa)
uppUnannotated protein; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
tdkUnannotated protein. (202 aa)
purAUnannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
guaBUnannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
tmkUnannotated protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (207 aa)
tilSUnannotated protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (463 aa)
hptUnannotated protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa)
ftsHUnannotated protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (652 aa)
guaAUnannotated protein; Catalyzes the synthesis of GMP from XMP. (512 aa)
CHR53_02320Unannotated protein. (442 aa)
purEUnannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa)
purKUnannotated protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (384 aa)
CHR53_02390Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (432 aa)
purCUnannotated protein; Belongs to the SAICAR synthetase family. (237 aa)
purSUnannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (84 aa)
purQUnannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (227 aa)
purLUnannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (742 aa)
purFUnannotated protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (469 aa)
purMUnannotated protein. (344 aa)
purNUnannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (200 aa)
purHUnannotated protein. (512 aa)
purDUnannotated protein; Belongs to the GARS family. (422 aa)
CHR53_03305Unannotated protein. (149 aa)
CHR53_03485Unannotated protein. (411 aa)
CHR53_04085Unannotated protein. (158 aa)
CHR53_04875Unannotated protein. (196 aa)
CHR53_06305Unannotated protein. (226 aa)
carAUnannotated protein; Belongs to the CarA family. (357 aa)
carBUnannotated protein. (1077 aa)
argFUnannotated protein; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (317 aa)
deoC-2Unannotated protein; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (224 aa)
pyrRUnannotated protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (180 aa)
CHR53_09355Unannotated protein. (437 aa)
pyrBUnannotated protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (313 aa)
pyrCUnannotated protein; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (428 aa)
carA-2Unannotated protein; Belongs to the CarA family. (363 aa)
carB-2Unannotated protein; Belongs to the CarB family. (1068 aa)
pyrKUnannotated protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (257 aa)
pyrDUnannotated protein; Catalyzes the conversion of dihydroorotate to orotate. (313 aa)
pyrFUnannotated protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (238 aa)
pyrEUnannotated protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (210 aa)
guaDUnannotated protein; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (454 aa)
CHR53_12730Unannotated protein. (436 aa)
xptUnannotated protein; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (197 aa)
CHR53_12900Unannotated protein. (455 aa)
CHR53_12940Unannotated protein. (442 aa)
allBUnannotated protein. (489 aa)
CHR53_13090Unannotated protein; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa)
CHR53_13305Unannotated protein. (70 aa)
CHR53_13310Unannotated protein. (491 aa)
hydAUnannotated protein. (472 aa)
CHR53_13320Unannotated protein. (428 aa)
CHR53_13325Unannotated protein. (456 aa)
CHR53_13480Unannotated protein; Belongs to the 5'-nucleotidase family. (572 aa)
CHR53_14375Unannotated protein. (153 aa)
CHR53_14380Unannotated protein. (430 aa)
Your Current Organism:
Bacillus mesonae
NCBI taxonomy Id: 1193713
Other names: B. mesonae, Bacillus mesonae Liu et al. 2014, Bacillus sp. FJAT-13985, CGMCC1.12238, DSM 25968, strain FJAT-13985
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