STRINGSTRING
CHR53_17375 CHR53_17375 xth xth CHR53_18480 CHR53_18480 CHR53_18505 CHR53_18505 nth nth sigA sigA dnaG dnaG CHR53_20170 CHR53_20170 CHR53_20180 CHR53_20180 recJ recJ uvrC uvrC CHR53_21055 CHR53_21055 mutM mutM polA polA CHR53_21275 CHR53_21275 uvrA uvrA uvrB uvrB CHR53_23465 CHR53_23465 CHR53_28020 CHR53_28020 CHR53_28060 CHR53_28060 dnaA dnaA CHR53_00010 CHR53_00010 dnaX dnaX CHR53_00205 CHR53_00205 mfd mfd CHR53_02760 CHR53_02760 CHR53_03045 CHR53_03045 CHR53_05510 CHR53_05510 recQ recQ topB topB recX recX mutY mutY recG recG dprA dprA topA topA polC polC CHR53_09885 CHR53_09885 CHR53_09895 CHR53_09895 GCA_001636315_04415 GCA_001636315_04415 lexA lexA sbcD sbcD CHR53_10765 CHR53_10765 CHR53_15760 CHR53_15760
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
CHR53_17375Unannotated protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (269 aa)
xthUnannotated protein. (250 aa)
CHR53_18480Unannotated protein. (218 aa)
CHR53_18505Unannotated protein. (297 aa)
nthUnannotated protein; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (223 aa)
sigAUnannotated protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (375 aa)
dnaGUnannotated protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (602 aa)
CHR53_20170Unannotated protein. (338 aa)
CHR53_20180Unannotated protein. (774 aa)
recJUnannotated protein. (787 aa)
uvrCUnannotated protein; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (591 aa)
CHR53_21055Unannotated protein. (572 aa)
mutMUnannotated protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (277 aa)
polAUnannotated protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (878 aa)
CHR53_21275Unannotated protein. (1121 aa)
uvrAUnannotated protein; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (957 aa)
uvrBUnannotated protein; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the [...] (659 aa)
CHR53_23465Unannotated protein. (238 aa)
CHR53_28020Unannotated protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (454 aa)
CHR53_28060Unannotated protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (172 aa)
dnaAUnannotated protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (448 aa)
CHR53_00010Unannotated protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication [...] (378 aa)
dnaXUnannotated protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (563 aa)
CHR53_00205Unannotated protein. (335 aa)
mfdUnannotated protein; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1180 aa)
CHR53_02760Unannotated protein. (759 aa)
CHR53_03045Unannotated protein. (354 aa)
CHR53_05510Unannotated protein. (202 aa)
recQUnannotated protein. (707 aa)
topBUnannotated protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (729 aa)
recXUnannotated protein; Modulates RecA activity; Belongs to the RecX family. (268 aa)
mutYUnannotated protein; Adenine glycosylase active on G-A mispairs. (366 aa)
recGUnannotated protein; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (682 aa)
dprAUnannotated protein. (292 aa)
topAUnannotated protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (692 aa)
polCUnannotated protein; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1441 aa)
CHR53_09885Unannotated protein. (100 aa)
CHR53_09895Unannotated protein. (133 aa)
GCA_001636315_04415Unannotated protein. (112 aa)
lexAUnannotated protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (207 aa)
sbcDUnannotated protein; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (382 aa)
CHR53_10765Unannotated protein. (1045 aa)
CHR53_15760Unannotated protein. (420 aa)
Your Current Organism:
Bacillus mesonae
NCBI taxonomy Id: 1193713
Other names: B. mesonae, Bacillus mesonae Liu et al. 2014, Bacillus sp. FJAT-13985, CGMCC1.12238, DSM 25968, strain FJAT-13985
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