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| | thiE | Unannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (215 aa) |
| | CHR53_11465 | Unannotated protein. (427 aa) |
| | tenA | Unannotated protein; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. (223 aa) |
| | CHR53_11475 | Unannotated protein. (262 aa) |
| | CHR53_11480 | Unannotated protein. (257 aa) |
| | CHR53_11485 | Unannotated protein. (332 aa) |
| | CHR53_11660 | Unannotated protein. (203 aa) |
| | cobA | Unannotated protein. (258 aa) |
| | CHR53_11700 | Unannotated protein. (241 aa) |
| | CHR53_11865 | Unannotated protein. (136 aa) |
| | CHR53_11990 | Unannotated protein. (411 aa) |
| | CHR53_12480 | Unannotated protein. (261 aa) |
| | CHR53_12500 | Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (181 aa) |
| | CHR53_12590 | Unannotated protein. (136 aa) |
| | xpt | Unannotated protein; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (197 aa) |
| | selA | Unannotated protein; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (469 aa) |
| | CHR53_12985 | Unannotated protein. (248 aa) |
| | CHR53_13140 | Unannotated protein. (186 aa) |
| | CHR53_13370 | Unannotated protein. (273 aa) |
| | CHR53_13460 | Unannotated protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (348 aa) |
| | pabB | Unannotated protein. (581 aa) |
| | thiC | Unannotated protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (590 aa) |
| | CHR53_13725 | Unannotated protein. (140 aa) |
| | prs-2 | Unannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | CHR53_13930 | Unannotated protein. (438 aa) |
| | CHR53_13940 | Unannotated protein. (329 aa) |
| | CHR53_14405 | Unannotated protein; Belongs to the sigma-70 factor family. (288 aa) |
| | CHR53_14420 | Unannotated protein. (127 aa) |
| | CHR53_14645 | Unannotated protein. (128 aa) |
| | CHR53_14755 | Unannotated protein; Belongs to the sigma-70 factor family. (308 aa) |
| | CHR53_14920 | Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (232 aa) |
| | GCA_001636315_05445 | Unannotated protein. (71 aa) |
| | GCA_001636315_05447 | Unannotated protein. (660 aa) |
| | CHR53_15040 | Unannotated protein. (129 aa) |
| | CHR53_15760 | Unannotated protein. (420 aa) |
| | CHR53_15790 | Unannotated protein. (395 aa) |
| | CHR53_15840 | Unannotated protein. (259 aa) |
| | CHR53_00910 | Unannotated protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (343 aa) |
| | sigW | Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (187 aa) |
| | dacA | Unannotated protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (273 aa) |
| | dacB-2 | Unannotated protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (207 aa) |
| | CHR53_02125 | Unannotated protein. (373 aa) |
| | CHR53_02130 | Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (188 aa) |
| | guaA | Unannotated protein; Catalyzes the synthesis of GMP from XMP. (512 aa) |
| | purE | Unannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa) |
| | purK | Unannotated protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (384 aa) |
| | CHR53_02390 | Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (432 aa) |
| | purC | Unannotated protein; Belongs to the SAICAR synthetase family. (237 aa) |
| | purS | Unannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (84 aa) |
| | purQ | Unannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (227 aa) |
| | purL | Unannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (742 aa) |
| | purF | Unannotated protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (469 aa) |
| | purM | Unannotated protein. (344 aa) |
| | purN | Unannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (200 aa) |
| | purH | Unannotated protein. (512 aa) |
| | purD | Unannotated protein; Belongs to the GARS family. (422 aa) |
| | CHR53_02630 | Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (182 aa) |
| | CHR53_02660 | Unannotated protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (487 aa) |
| | CHR53_02780 | Unannotated protein; Belongs to the pyridoxine kinase family. (282 aa) |
| | CHR53_02830 | Unannotated protein. (689 aa) |
| | cbiA | Unannotated protein; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (462 aa) |
| | hemG | Unannotated protein; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (460 aa) |
| | ctaB | Unannotated protein; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. (342 aa) |
| | CHR53_03375 | Unannotated protein. (209 aa) |
| | CHR53_03440 | Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (197 aa) |
| | CHR53_03595 | Unannotated protein. (439 aa) |
| | CHR53_03770 | Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (171 aa) |
| | CHR53_03910 | Unannotated protein. (444 aa) |
| | CHR53_04080 | Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (160 aa) |
| | dacB-3 | Unannotated protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (207 aa) |
| | CHR53_04780 | Unannotated protein. (190 aa) |
| | CHR53_04875 | Unannotated protein. (196 aa) |
| | CHR53_04990 | Unannotated protein. (68 aa) |
| | CHR53_05000 | Unannotated protein. (126 aa) |
| | CHR53_05060 | Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (177 aa) |
| | CHR53_05140 | Unannotated protein. (178 aa) |
| | CHR53_05200 | Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (179 aa) |
| | CHR53_05205 | Unannotated protein. (444 aa) |
| | CHR53_05340 | Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (174 aa) |
| | CHR53_05645 | Unannotated protein. (314 aa) |
| | GCA_001636315_03711 | Unannotated protein. (420 aa) |
| | CHR53_06305 | Unannotated protein. (226 aa) |
| | aroK | Unannotated protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | aroD | Unannotated protein; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (252 aa) |
| | carA | Unannotated protein; Belongs to the CarA family. (357 aa) |
| | carB | Unannotated protein. (1077 aa) |
| | hemL-2 | Unannotated protein. (431 aa) |
| | GCA_001636315_03901 | Unannotated protein. (420 aa) |
| | GCA_001636315_03902 | Unannotated protein. (412 aa) |
| | queG | Unannotated protein. (376 aa) |
| | CHR53_07490 | Unannotated protein. (257 aa) |
| | CHR53_07620 | Unannotated protein. (412 aa) |
| | CHR53_07810 | Unannotated protein. (504 aa) |
| | hemE | Unannotated protein; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (348 aa) |
| | hemH | Unannotated protein; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (311 aa) |
| | guaB | Unannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa) |
| | CHR53_00010 | Unannotated protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication [...] (378 aa) |
| | CHR53_28020 | Unannotated protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (454 aa) |
| | purA | Unannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa) |
| | CHR53_27830 | Unannotated protein. (408 aa) |
| | CHR53_27765 | Unannotated protein; Catalyzes the oxidation of L-aspartate to iminoaspartate. (527 aa) |
| | CHR53_27760 | Unannotated protein; Belongs to the NadC/ModD family. (278 aa) |
| | nadA | Unannotated protein; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (320 aa) |
| | CHR53_07940 | Unannotated protein; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (473 aa) |
| | CHR53_08070 | Unannotated protein. (342 aa) |
| | CHR53_08365 | Unannotated protein. (212 aa) |
| | nadK-2 | Unannotated protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (264 aa) |
| | CHR53_08445 | Unannotated protein. (140 aa) |
| | sigI | Unannotated protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; Belongs to the sigma-70 factor family. SigI subfamily. (248 aa) |
| | CHR53_08870 | Unannotated protein; Belongs to the UPF0356 family. (69 aa) |
| | ctaA | Unannotated protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 1 subfamily. (301 aa) |
| | ctaB-2 | Unannotated protein; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. (308 aa) |
| | coaD | Unannotated protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (162 aa) |
| | CHR53_09160 | Unannotated protein. (445 aa) |
| | CHR53_09285 | Unannotated protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (239 aa) |
| | sigG | Unannotated protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (259 aa) |
| | pyrR | Unannotated protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (180 aa) |
| | pyrB | Unannotated protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (313 aa) |
| | pyrC | Unannotated protein; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (428 aa) |
| | carA-2 | Unannotated protein; Belongs to the CarA family. (363 aa) |
| | carB-2 | Unannotated protein; Belongs to the CarB family. (1068 aa) |
| | pyrK | Unannotated protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (257 aa) |
| | pyrD | Unannotated protein; Catalyzes the conversion of dihydroorotate to orotate. (313 aa) |
| | pyrF | Unannotated protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (238 aa) |
| | pyrE | Unannotated protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (210 aa) |
| | gmk | Unannotated protein; Essential for recycling GMP and indirectly, cGMP. (204 aa) |
| | rpoZ | Unannotated protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (73 aa) |
| | coaBC | Unannotated protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (408 aa) |
| | priA | Unannotated protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (803 aa) |
| | CHR53_09480 | Unannotated protein. (215 aa) |
| | pyrH | Unannotated protein; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa) |
| | polC | Unannotated protein; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1441 aa) |
| | nusA | Unannotated protein; Participates in both transcription termination and antitermination. (373 aa) |
| | ribF | Unannotated protein; Belongs to the ribF family. (314 aa) |
| | cinA | Unannotated protein; Belongs to the CinA family. (416 aa) |
| | ltrA-3 | Unannotated protein. (625 aa) |
| | CHR53_09965 | Unannotated protein; Belongs to the ribF family. (298 aa) |
| | cobD | Unannotated protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (319 aa) |
| | CHR53_11220 | Unannotated protein. (194 aa) |
| | cobQ | Unannotated protein; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (285 aa) |
| | cobS | Unannotated protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (255 aa) |
| | CHR53_11240 | Unannotated protein. (146 aa) |
| | CHR53_11245 | Unannotated protein; Belongs to the Cob(I)alamin adenosyltransferase family. (194 aa) |
| | CHR53_11255 | Unannotated protein. (238 aa) |
| | CHR53_11350 | Unannotated protein. (246 aa) |
| | CHR53_11375 | Unannotated protein. (353 aa) |
| | thiM | Unannotated protein; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (269 aa) |
| | thiD-2 | Unannotated protein. (272 aa) |
| | GCA_001636315_00024 | Unannotated protein. (232 aa) |
| | purU | Unannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (299 aa) |
| | queE | Unannotated protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (240 aa) |
| | queD | Unannotated protein. (159 aa) |
| | queC | Unannotated protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (219 aa) |
| | queF | Unannotated protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (166 aa) |
| | CHR53_16575 | Unannotated protein. (338 aa) |
| | thiG | Unannotated protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (255 aa) |
| | thiS | Unannotated protein. (67 aa) |
| | thiO | Unannotated protein. (369 aa) |
| | CHR53_16595 | Unannotated protein. (205 aa) |
| | CHR53_16610 | Unannotated protein. (274 aa) |
| | CHR53_16740 | Unannotated protein. (226 aa) |
| | CHR53_16745 | Unannotated protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (217 aa) |
| | CHR53_16860 | Unannotated protein. (286 aa) |
| | CHR53_16965 | Unannotated protein. (271 aa) |
| | CHR53_17025 | Unannotated protein. (296 aa) |
| | CHR53_17055 | Unannotated protein. (179 aa) |
| | CHR53_17275 | Unannotated protein. (389 aa) |
| | trpA | Unannotated protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa) |
| | trpB | Unannotated protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (400 aa) |
| | trpF | Unannotated protein; Belongs to the TrpF family. (208 aa) |
| | trpC | Unannotated protein; Belongs to the TrpC family. (263 aa) |
| | trpD | Unannotated protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa) |
| | trpE | Unannotated protein; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (463 aa) |
| | ligD | Unannotated protein. (614 aa) |
| | CHR53_18215 | Unannotated protein. (424 aa) |
| | CHR53_18340 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (163 aa) |
| | thyA | Unannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | CHR53_18385 | Unannotated protein. (414 aa) |
| | CHR53_18685 | Unannotated protein. (233 aa) |
| | dinG | Unannotated protein; 3'-5' exonuclease. (942 aa) |
| | aroA | Unannotated protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa) |
| | CHR53_18820 | Unannotated protein. (368 aa) |
| | aroH | Unannotated protein; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (123 aa) |
| | aroB | Unannotated protein; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (356 aa) |
| | aroC | Unannotated protein; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (392 aa) |
| | ndk | Unannotated protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (148 aa) |
| | CHR53_18870 | Unannotated protein. (78 aa) |
| | folE | Unannotated protein. (188 aa) |
| | cmk | Unannotated protein. (224 aa) |
| | CHR53_19070 | Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (183 aa) |
| | sigF | Unannotated protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (252 aa) |
| | CHR53_19290 | Unannotated protein; Belongs to the DNA polymerase type-Y family. (419 aa) |
| | dinB | Unannotated protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (425 aa) |
| | dxs | Unannotated protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (631 aa) |
| | folD | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | nusB | Unannotated protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (129 aa) |
| | accC | Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | CHR53_19695 | Unannotated protein; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (852 aa) |
| | GCA_001636315_00795 | Unannotated protein. (267 aa) |
| | CHR53_19840 | Unannotated protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (188 aa) |
| | CHR53_19860 | Unannotated protein. (226 aa) |
| | sigA | Unannotated protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (375 aa) |
| | dnaG | Unannotated protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (602 aa) |
| | CHR53_20140 | Unannotated protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (379 aa) |
| | CHR53_20170 | Unannotated protein. (338 aa) |
| | CHR53_20210 | Unannotated protein. (188 aa) |
| | nadD | Unannotated protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (189 aa) |
| | aroE | Unannotated protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (281 aa) |
| | sigK | Unannotated protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (238 aa) |
| | paaX | Unannotated protein. (293 aa) |
| | udk | Unannotated protein. (210 aa) |
| | CHR53_20570 | Unannotated protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (731 aa) |
| | apt | Unannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa) |
| | tgt | Unannotated protein; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. [...] (379 aa) |
| | queA | Unannotated protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (342 aa) |
| | CHR53_20625 | Unannotated protein. (68 aa) |
| | pheA | Unannotated protein. (284 aa) |
| | CHR53_20830 | Unannotated protein; Belongs to the folylpolyglutamate synthase family. (440 aa) |
| | hemL | Unannotated protein. (428 aa) |
| | CHR53_20870 | Unannotated protein; Belongs to the ALAD family. (325 aa) |
| | CHR53_20875 | Unannotated protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (270 aa) |
| | hemC | Unannotated protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (311 aa) |
| | hemA | Unannotated protein; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (447 aa) |
| | CHR53_21055 | Unannotated protein. (572 aa) |
| | CHR53_21075 | Unannotated protein. (97 aa) |
| | dut | Unannotated protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (145 aa) |
| | CHR53_21165 | Unannotated protein. (309 aa) |
| | CHR53_21170 | Unannotated protein. (466 aa) |
| | coaE | Unannotated protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (199 aa) |
| | polA | Unannotated protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (878 aa) |
| | accA | Unannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa) |
| | accD | Unannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (292 aa) |
| | CHR53_21275 | Unannotated protein. (1121 aa) |
| | ackA | Unannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa) |
| | nadK | Unannotated protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (275 aa) |
| | thiI | Unannotated protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (402 aa) |
| | CHR53_21450 | Unannotated protein. (573 aa) |
| | CHR53_21475 | Unannotated protein. (358 aa) |
| | CHR53_21605 | Unannotated protein. (343 aa) |
| | CHR53_21725 | Unannotated protein. (259 aa) |
| | menF | Unannotated protein; Catalyzes the conversion of chorismate to isochorismate. (466 aa) |
| | CHR53_21990 | Unannotated protein. (390 aa) |
| | CHR53_22295 | Unannotated protein. (329 aa) |
| | CHR53_22875 | Unannotated protein. (252 aa) |
| | nadE | Unannotated protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (273 aa) |
| | rpoN | Unannotated protein. (440 aa) |
| | CHR53_23655 | Unannotated protein. (445 aa) |
| | GCA_001636315_01749 | Unannotated protein. (140 aa) |
| | CHR53_24280 | Unannotated protein. (446 aa) |
| | CHR53_24580 | Unannotated protein; Belongs to the sigma-70 factor family. (239 aa) |
| | fliI | Unannotated protein. (441 aa) |
| | CHR53_24780 | Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (159 aa) |
| | kynU | Unannotated protein; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (424 aa) |
| | CHR53_26580 | Unannotated protein. (456 aa) |
| | murA | Unannotated protein; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (436 aa) |
| | CHR53_26820 | Unannotated protein; Belongs to the sigma-70 factor family. (255 aa) |
| | atpC | Unannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. (135 aa) |
| | atpD | Unannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (474 aa) |
| | atpG | Unannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (286 aa) |
| | atpA | Unannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (502 aa) |
| | atpH | Unannotated protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (178 aa) |
| | atpF | Unannotated protein; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (174 aa) |
| | atpE | Unannotated protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (70 aa) |
| | atpB | Unannotated protein; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (236 aa) |
| | upp | Unannotated protein; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | tdk | Unannotated protein. (202 aa) |
| | rho | Unannotated protein; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (421 aa) |
| | murA-2 | Unannotated protein; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (428 aa) |
| | pyrG | Unannotated protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (531 aa) |
| | rpoE | Unannotated protein; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family. (189 aa) |
| | pta | Unannotated protein. (323 aa) |
| | CHR53_27320 | Unannotated protein; May function as heme-dependent peroxidase. (248 aa) |
| | CHR53_27340 | Unannotated protein. (339 aa) |
| | thiD | Unannotated protein. (271 aa) |
| | pdxS | Unannotated protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (294 aa) |
| | pdxT | Unannotated protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (196 aa) |
| | serS | Unannotated protein; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa) |
| | CHR53_00105 | Unannotated protein. (231 aa) |
| | CHR53_00110 | Unannotated protein. (221 aa) |
| | dnaX | Unannotated protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (563 aa) |
| | tmk | Unannotated protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (207 aa) |
| | CHR53_00205 | Unannotated protein. (335 aa) |
| | glmU | Unannotated protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (457 aa) |
| | prs | Unannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (318 aa) |
| | hpt | Unannotated protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa) |
| | coaX | Unannotated protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (259 aa) |
| | folP | Unannotated protein; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (280 aa) |
| | folB | Unannotated protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa) |
| | folK | Unannotated protein. (175 aa) |
| | CHR53_00600 | Unannotated protein; Belongs to the sigma-70 factor family. (216 aa) |
| | nusG | Unannotated protein; Participates in transcription elongation, termination and antitermination. (194 aa) |
| | rpoB | Unannotated protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1186 aa) |
| | rpoC | Unannotated protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1199 aa) |
| | adk | Unannotated protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa) |
| | rpoA | Unannotated protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (314 aa) |
| | ltrA | Unannotated protein. (420 aa) |
| | ltrA-2 | Unannotated protein. (412 aa) |
