(16 nodes) Pyrimidine metabolism network (Bacillus oceanisediminis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A361_00115	Deoxycytidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
	A361_02645	Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (544 aa)
	A361_03330	Short-chain dehydrogenase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (132 aa)
	A361_05190	2',3'-cyclic-nucleotide 2'-phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1188 aa)
	A361_08510	Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (527 aa)
	add	Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (333 aa)
	A361_13285	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (380 aa)
	A361_17350	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (101 aa)
	A361_18380	Nucleoside hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
	deoD	Purine nucleoside phosphorylase DeoD-type; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
	deoA	Pyrimidine-nucleoside phosphorylase; Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
	A361_19840	Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (273 aa)
	deoB	Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (394 aa)
	A361_21095	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (132 aa)
	udk	Uridine kinase; Functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
	upp	Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)

Your Current Organism:

Bacillus oceanisediminis

NCBI taxonomy Id: 1196031
Other names: B. oceanisediminis 2691, Bacillus oceanisediminis 2691

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A361_00115	A361_02645	A361_00115	A361_02645	Deoxycytidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.	0.901
A361_00115	A361_03330	A361_00115	A361_03330	Deoxycytidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Short-chain dehydrogenase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.910
A361_00115	A361_05190	A361_00115	A361_05190	Deoxycytidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2',3'-cyclic-nucleotide 2'-phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
A361_00115	A361_08510	A361_00115	A361_08510	Deoxycytidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.	0.901
A361_00115	A361_13285	A361_00115	A361_13285	Deoxycytidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.	0.901
A361_00115	A361_17350	A361_00115	A361_17350	Deoxycytidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.925
A361_00115	A361_18380	A361_00115	A361_18380	Deoxycytidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleoside hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
A361_00115	A361_19840	A361_00115	A361_19840	Deoxycytidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.906
A361_00115	A361_21095	A361_00115	A361_21095	Deoxycytidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.910
A361_00115	add	A361_00115	A361_11050	Deoxycytidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.	0.900
A361_00115	deoD	A361_00115	A361_18630	Deoxycytidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Purine nucleoside phosphorylase DeoD-type; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.907
A361_02645	A361_00115	A361_02645	A361_00115	Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.	Deoxycytidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
A361_02645	A361_03330	A361_02645	A361_03330	Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.	Short-chain dehydrogenase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.903
A361_02645	A361_05190	A361_02645	A361_05190	Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.	2',3'-cyclic-nucleotide 2'-phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.905
A361_02645	A361_08510	A361_02645	A361_08510	Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.	Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.	0.928
A361_02645	A361_13285	A361_02645	A361_13285	Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.	0.969
A361_02645	A361_17350	A361_02645	A361_17350	Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.903
A361_02645	A361_18380	A361_02645	A361_18380	Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.	Nucleoside hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.906
A361_02645	A361_19840	A361_02645	A361_19840	Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.	Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.914
A361_02645	A361_21095	A361_02645	A361_21095	Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.903