(19 nodes) Mixed, incl. Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, and Dihydrolipoamide dehydrogenase network (Bacillus oceanisediminis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	pdhA	Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (371 aa)
	A361_08795	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
	A361_08800	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
	A361_08805	Dihydrolipoyl dehydrogenase; E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
	pdhA-2	Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (355 aa)
	A361_12125	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
	A361_12130	Dihydrolipoyllysine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
	A361_12135	Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
	acoL	Dihydrolipoyl dehydrogenase; E3 component of acetoin cleaving system; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (459 aa)
	A361_16225	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
	A361_16230	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
	A361_16235	Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
	A361_20095	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
	A361_20100	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
	A361_20105	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
	A361_20110	Dihydrolipoyl dehydrogenase; E3 component of the branched-chain alpha-keto acid dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
	buk	Butyrate kinase; Catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetokinase family. (369 aa)
	A361_20120	Leucine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (364 aa)
	A361_20125	Catalyzes the synthesis of butanoylphosphate from butanoyl-CoA and inorganic phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)

Your Current Organism:

Bacillus oceanisediminis

NCBI taxonomy Id: 1196031
Other names: B. oceanisediminis 2691, Bacillus oceanisediminis 2691

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A361_08795	A361_08800	A361_08795	A361_08800	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
A361_08795	A361_08805	A361_08795	A361_08805	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoyl dehydrogenase; E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
A361_08795	A361_12125	A361_08795	A361_12125	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.904
A361_08795	A361_12130	A361_08795	A361_12130	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoyllysine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
A361_08795	A361_12135	A361_08795	A361_12135	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.989
A361_08795	A361_16225	A361_08795	A361_16225	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.995
A361_08795	A361_16235	A361_08795	A361_16235	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
A361_08795	A361_20095	A361_08795	A361_20095	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.979
A361_08795	A361_20105	A361_08795	A361_20105	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
A361_08795	A361_20110	A361_08795	A361_20110	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoyl dehydrogenase; E3 component of the branched-chain alpha-keto acid dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.987
A361_08795	A361_20125	A361_08795	A361_20125	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Catalyzes the synthesis of butanoylphosphate from butanoyl-CoA and inorganic phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.480
A361_08795	acoL	A361_08795	A361_16220	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoyl dehydrogenase; E3 component of acetoin cleaving system; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.987
A361_08795	buk	A361_08795	A361_20115	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Butyrate kinase; Catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetokinase family.	0.467
A361_08795	pdhA	A361_08795	A361_08790	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).	0.999
A361_08795	pdhA-2	A361_08795	A361_12120	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).	0.999
A361_08800	A361_08795	A361_08800	A361_08795	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
A361_08800	A361_08805	A361_08800	A361_08805	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoyl dehydrogenase; E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
A361_08800	A361_12125	A361_08800	A361_12125	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
A361_08800	A361_12130	A361_08800	A361_12130	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoyllysine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.914
A361_08800	A361_12135	A361_08800	A361_12135	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.995