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A361_02665 A361_02665 A361_00445 A361_00445 A361_00625 A361_00625 A361_01365 A361_01365 A361_02270 A361_02270 thiC thiC thiE-2 thiE-2 A361_08400 A361_08400 A361_02670 A361_02670 thiG thiG A361_02680 A361_02680 A361_03280 A361_03280 mtnK mtnK mtnA mtnA A361_05805 A361_05805 A361_06425 A361_06425 A361_07010 A361_07010 A361_08190 A361_08190 A361_08205 A361_08205 A361_26345 A361_26345 A361_26340 A361_26340 A361_26335 A361_26335 A361_26315 A361_26315 eutD eutD lipL lipL A361_25425 A361_25425 A361_25410 A361_25410 A361_25320 A361_25320 A361_25200 A361_25200 A361_24325 A361_24325 lipA lipA A361_23755 A361_23755 A361_22785 A361_22785 metK metK A361_22610 A361_22610 A361_22445 A361_22445 thiI thiI ackA ackA accD accD accA accA mtnN mtnN lipM lipM A361_20200 A361_20200 folD-2 folD-2 dxs dxs A361_19335 A361_19335 A361_19330 A361_19330 metAA metAA A361_18705 A361_18705 A361_18690 A361_18690 folD folD bioB bioB A361_18155 A361_18155 A361_17530 A361_17530 cysI cysI A361_17180 A361_17180 A361_16950 A361_16950 A361_16235 A361_16235 A361_16225 A361_16225 A361_15530 A361_15530 A361_15525 A361_15525 A361_15235 A361_15235 A361_15215 A361_15215 A361_14910 A361_14910 A361_14690 A361_14690 A361_14680 A361_14680 A361_14545 A361_14545 A361_14350 A361_14350 A361_13785 A361_13785 cysH cysH sat-2 sat-2 cysC-2 cysC-2 thiM thiM A361_13355 A361_13355 thiE thiE A361_13090 A361_13090 A361_12740 A361_12740 A361_12195 A361_12195 sat sat cysC cysC asd asd A361_09455 A361_09455 A361_09125 A361_09125 mtnD mtnD mtnB mtnB mtnX mtnX mtnW mtnW
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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A361_02665Glycine oxidase ThiO; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
A361_00445Cysteine synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (309 aa)
A361_00625Serine O-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
A361_01365Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (127 aa)
A361_02270Thiaminase II; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. (229 aa)
thiCPhosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (594 aa)
thiE-2Thiamine phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (203 aa)
A361_08400Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
A361_02670Thiamine biosynthesis protein ThiS; With ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (67 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (255 aa)
A361_02680Thiamine biosynthesis protein MoeB; Catalyzes the formation of a high-energy acyladenylate intermediate and subsequently to the formation of a thiocarboxylate at the C termini of MoaD or ThiS in the molybdopterin or thiamin pyrophosphate biosynthesis pathways; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
A361_03280Peptidase M20; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
mtnKS-methyl-5-thioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (407 aa)
mtnAS-methyl-5-thioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (353 aa)
A361_05805Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (138 aa)
A361_06425Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
A361_07010Peptidase M20; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
A361_08190ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
A361_08205ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
A361_26345Bacillithiol biosynthesis deacetylase BshB2; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)
A361_26340Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (115 aa)
A361_26335Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of three vitamin B6 precursors, pyridoxal, pyridoxine and pyridoxamine; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
A361_26315Thiamine biosynthesis protein MoeB; Catalyzes the formation of a high-energy acyladenylate intermediate and subsequently to the formation of a thiocarboxylate at the C termini of MoaD or ThiS in the molybdopterin or thiamin pyrophosphate biosynthesis pathways; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
eutDPhosphate acetyltransferase; In Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
lipLOctanoyltransferase; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. (280 aa)
A361_25425Peptidase M20; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
A361_25410Peptidase M20; Derived by automated computational analysis using gene prediction method: Protein Homology. (424 aa)
A361_25320Peptidase M20; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
A361_25200Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (835 aa)
A361_24325Glycine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (305 aa)
A361_23755Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (432 aa)
A361_22785Spermidine/putrescine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (397 aa)
A361_22610Cysteine synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa)
A361_22445acetate--CoA ligase; Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (572 aa)
thiItRNA 4-thiouridine(8) synthase ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (402 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa)
accDacetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (292 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa)
mtnN5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (232 aa)
lipMOctanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. (278 aa)
A361_20200acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa)
folD-2Bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (291 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (630 aa)
A361_19335Bacillithiol biosynthesis deacetylase BshB1; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
A361_19330N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
metAAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (302 aa)
A361_18705Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa)
A361_18690Acetylornithine deacetylase; Catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
bioBBiotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (330 aa)
A361_18155Nitrate/sulfonate/bicarbonate ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
A361_17530Sulfite reductase [NADPH] flavoprotein alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (603 aa)
cysISulfite reductase; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (573 aa)
A361_171805'-methylthioadenosine nucleosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
A361_16950Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (453 aa)
A361_16235Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
A361_16225Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
A361_15530Peptidase M20; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
A361_15525Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
A361_15235Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (437 aa)
A361_15215Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (466 aa)
A361_14910Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
A361_14690Sarcosine oxidase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
A361_14680Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
A361_14545FAD-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
A361_14350Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (141 aa)
A361_13785Propanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (217 aa)
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (238 aa)
sat-2ATP sulfurylase; ATPS; converts ATP and sulfate to 5'phosphosulfate and pyrophosphate; in some organisms this enzyme is involved in the incorporation of inorganic sulfate while in others it is involved in the production of ATP in the reverse direction; the enzyme from Thermus thermophilus is dimeric and binds a zinc ion that is coordinated by cysteine and histidine residues that are not found in all related proteins but is found in some thermophilic organisms; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
cysC-2Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (199 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (275 aa)
A361_13355Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
thiEThiamine phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (222 aa)
A361_13090Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1148 aa)
A361_127402,3-diketo-5-methylthio-1-phosphopentane phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
A361_121958-amino-7-oxononanoate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
satATP sulfurylase; ATPS; converts ATP and sulfate to 5'phosphosulfate and pyrophosphate; in some organisms this enzyme is involved in the incorporation of inorganic sulfate while in others it is involved in the production of ATP in the reverse direction; the enzyme from Thermus thermophilus is dimeric and binds a zinc ion that is coordinated by cysteine and histidine residues that are not found in all related proteins but is found in some thermophilic organisms; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
cysCAdenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (197 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (349 aa)
A361_09455Thiamine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
A361_09125Biotin carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (447 aa)
mtnDAcireductone dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (180 aa)
mtnBMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). (211 aa)
mtnX2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphate phosphatase; Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). (220 aa)
mtnW2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphate (HK-MTPenyl-1-P); Belongs to the RuBisCO large chain family. Type IV subfamily. (410 aa)
Your Current Organism:
Bacillus oceanisediminis
NCBI taxonomy Id: 1196031
Other names: B. oceanisediminis 2691, Bacillus oceanisediminis 2691
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