(68 nodes) Pyrimidine metabolism network (Talaromyces amestolkiae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BHQ10_009682	Glutamine amidotransferase type-1 domain-containing protein. (463 aa)
	BHQ10_000043	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (872 aa)
	BHQ10_000358	IU_nuc_hydro domain-containing protein. (954 aa)
	BHQ10_000376	MFS domain-containing protein. (526 aa)
	BHQ10_000613	Uncharacterized protein. (206 aa)
	BHQ10_000752	Amidohydro-rel domain-containing protein. (508 aa)
	BHQ10_009752	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (415 aa)
	BHQ10_000816	SurE domain-containing protein. (757 aa)
	BHQ10_000856	TLC domain-containing protein. (386 aa)
	BHQ10_001235	Uncharacterized protein. (486 aa)
	BHQ10_001247	Fungal_trans domain-containing protein. (465 aa)
	BHQ10_001432	F-box domain-containing protein. (715 aa)
	BHQ10_001460	Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. (394 aa)
	BHQ10_001578	IU_nuc_hydro domain-containing protein. (422 aa)
	BHQ10_002004	Amidohydro-rel domain-containing protein. (493 aa)
	BHQ10_002085	Uncharacterized protein. (662 aa)
	BHQ10_002159	OBG-type G domain-containing protein. (372 aa)
	BHQ10_002463	Thymidylat_synt domain-containing protein. (311 aa)
	BHQ10_002569	Uncharacterized protein. (1350 aa)
	BHQ10_002958	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (539 aa)
	BHQ10_009962	Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (209 aa)
	BHQ10_003177	Uncharacterized protein. (127 aa)
	BHQ10_003686	Nudix hydrolase domain-containing protein. (170 aa)
	BHQ10_003828	Uncharacterized protein. (108 aa)
	BHQ10_004039	Uncharacterized protein. (406 aa)
	BHQ10_004058	RED_N domain-containing protein. (575 aa)
	BHQ10_004111	MFS domain-containing protein. (1500 aa)
	BHQ10_004352	IU_nuc_hydro domain-containing protein. (369 aa)
	BHQ10_004551	Uncharacterized protein. (247 aa)
	BHQ10_004620	Uncharacterized protein. (130 aa)
	BHQ10_004645	Uncharacterized protein. (303 aa)
	BHQ10_004957	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (270 aa)
	BHQ10_005163	CMP/dCMP-type deaminase domain-containing protein. (148 aa)
	BHQ10_005253	Uncharacterized protein. (2263 aa)
	BHQ10_005394	Zn(2)-C6 fungal-type domain-containing protein. (622 aa)
	BHQ10_005437	dUTPase domain-containing protein. (205 aa)
	BHQ10_005484	Uncharacterized protein. (500 aa)
	BHQ10_005522	Uncharacterized protein; Belongs to the GroES chaperonin family. (102 aa)
	BHQ10_005757	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (897 aa)
	BHQ10_005693	Fungal_trans domain-containing protein. (611 aa)
	BHQ10_005785	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (288 aa)
	BHQ10_006009	MFS domain-containing protein. (529 aa)
	BHQ10_006018	HD domain-containing protein. (220 aa)
	BHQ10_005953	Zn(2)-C6 fungal-type domain-containing protein. (762 aa)
	BHQ10_006120	Amidohydro-rel domain-containing protein. (358 aa)
	BHQ10_006112	Pribosyltran domain-containing protein. (242 aa)
	BHQ10_006147	DHO_dh domain-containing protein. (477 aa)
	BHQ10_006281	MFS domain-containing protein. (590 aa)
	BHQ10_006402	Uncharacterized protein. (258 aa)
	BHQ10_006497	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (431 aa)
	BHQ10_006536	Uncharacterized protein. (460 aa)
	BHQ10_007068	Uridine kinase; Belongs to the uridine kinase family. (454 aa)
	BHQ10_007154	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (278 aa)
	BHQ10_007281	SurE domain-containing protein. (332 aa)
	BHQ10_007454	MFS domain-containing protein. (553 aa)
	BHQ10_007580	Thymidylate_kin domain-containing protein. (238 aa)
	BHQ10_007583	Nucleoside diphosphate kinase. (153 aa)
	BHQ10_007792	Importin N-terminal domain-containing protein. (1037 aa)
	BHQ10_007860	PfkB domain-containing protein. (944 aa)
	BHQ10_008058	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (317 aa)
	BHQ10_008248	dUTPase domain-containing protein. (172 aa)
	BHQ10_008566	Metallophos domain-containing protein. (607 aa)
	BHQ10_008750	Uncharacterized protein. (279 aa)
	BHQ10_008733	Uncharacterized protein. (1177 aa)
	BHQ10_009079	Uncharacterized protein. (116 aa)
	BHQ10_009085	Uncharacterized protein. (128 aa)
	BHQ10_009379	Amidohydro-rel domain-containing protein. (537 aa)
	BHQ10_009635	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (140 aa)

Your Current Organism:

Talaromyces amestolkiae

NCBI taxonomy Id: 1196081
Other names: CBS 132696, CBS H-21050, DTO 179F5, DTO179F5, Penicillium sp. CBS 263.93, Penicillium sp. CBS 274.95, Penicillium sp. GT11, T. amestolkiae, Talaromyces amestolkae, Talaromyces amestolkiae Yilmaz, Houbraken, Frisvad & Samson 2012, Talaromyces sp CMV-2012a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BHQ10_000043	BHQ10_000613	A0A364KKG2	A0A364KM44	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uncharacterized protein.	0.667
BHQ10_000043	BHQ10_001460	A0A364KKG2	A0A364KPH3	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.	0.749
BHQ10_000043	BHQ10_002159	A0A364KKG2	A0A364KRH4	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	OBG-type G domain-containing protein.	0.749
BHQ10_000043	BHQ10_002463	A0A364KKG2	A0A364KSG9	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Thymidylat_synt domain-containing protein.	0.940
BHQ10_000043	BHQ10_002958	A0A364KKG2	A0A364KTR9	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.849
BHQ10_000043	BHQ10_003686	A0A364KKG2	A0A364KVV8	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Nudix hydrolase domain-containing protein.	0.579
BHQ10_000043	BHQ10_004039	A0A364KKG2	A0A364KWU7	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uncharacterized protein.	0.999
BHQ10_000043	BHQ10_004551	A0A364KKG2	A0A364KYD0	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uncharacterized protein.	0.667
BHQ10_000043	BHQ10_004645	A0A364KKG2	A0A364KYJ7	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uncharacterized protein.	0.818
BHQ10_000043	BHQ10_005437	A0A364KKG2	A0A364L0V2	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	dUTPase domain-containing protein.	0.881
BHQ10_000043	BHQ10_005757	A0A364KKG2	A0A364L1R8	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family.	0.705
BHQ10_000043	BHQ10_006402	A0A364KKG2	A0A364L3K2	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uncharacterized protein.	0.731
BHQ10_000043	BHQ10_006536	A0A364KKG2	A0A364L408	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uncharacterized protein.	0.881
BHQ10_000043	BHQ10_007068	A0A364KKG2	A0A364L5I2	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uridine kinase; Belongs to the uridine kinase family.	0.667
BHQ10_000043	BHQ10_007580	A0A364KKG2	A0A364L6X3	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Thymidylate_kin domain-containing protein.	0.943
BHQ10_000043	BHQ10_007583	A0A364KKG2	A0A364L797	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Nucleoside diphosphate kinase.	0.941
BHQ10_000043	BHQ10_008750	A0A364KKG2	A0A364LAB2	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uncharacterized protein.	0.881
BHQ10_000043	BHQ10_009635	A0A364KKG2	A0A364LCW6	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.426
BHQ10_000043	BHQ10_009962	A0A364KKG2	A0A364LDQ3	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.916
BHQ10_000358	BHQ10_000613	A0A364KLB8	A0A364KM44	IU_nuc_hydro domain-containing protein.	Uncharacterized protein.	0.771

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