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rplO rplO rpmE rpmE rpsO rpsO SDN62586.1 SDN62586.1 SDN54580.1 SDN54580.1 SDN54191.1 SDN54191.1 rpsN rpsN rpmB-2 rpmB-2 rpmG-3 rpmG-3 rpmE2-2 rpmE2-2 rpsR-2 rpsR-2 rpmE2 rpmE2 SDN02541.1 SDN02541.1 rpsD rpsD rpmI rpmI rplT rplT SDM87273.1 SDM87273.1 rpsT rpsT rpmG-2 rpmG-2 rplK rplK rplA rplA rplJ rplJ rplL rplL rpsL rpsL rpsG rpsG rpsJ rpsJ rplC rplC rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplP rplP rpmC rpmC rpsQ rpsQ rplN rplN rplX rplX rplE rplE rpsZ rpsZ rpsH rpsH rplF rplF rplR rplR rpsE rpsE rpmD rpmD rpmJ-2 rpmJ-2 rpsM rpsM rpsK rpsK rplQ rplQ rplM rplM rpsI rpsI rplY rplY SDM60802.1 SDM60802.1 rpmH rpmH rpsF rpsF rpsR rpsR rplI rplI rpmJ rpmJ rpmG rpmG rplU rplU rpmA rpmA SDM30282.1 SDM30282.1 rpsB rpsB rplS rplS rpsP rpsP rpmF-2 rpmF-2 rpmB rpmB SDM20926.1 SDM20926.1 SDM12706.1 SDM12706.1 rpmF rpmF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rplOLSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (151 aa)
rpmELarge subunit ribosomal protein L31; Binds the 23S rRNA. (74 aa)
rpsOSSU ribosomal protein S15P; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (95 aa)
SDN62586.1Small subunit ribosomal protein S1. (189 aa)
SDN54580.1Hypothetical protein. (66 aa)
SDN54191.1Small subunit ribosomal protein S1. (338 aa)
rpsNSmall subunit ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rpmB-2Large subunit ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (80 aa)
rpmG-3LSU ribosomal protein L33P; Belongs to the bacterial ribosomal protein bL33 family. (64 aa)
rpmE2-2Large subunit ribosomal protein L31. (84 aa)
rpsR-2Small subunit ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (80 aa)
rpmE2Large subunit ribosomal protein L31. (89 aa)
SDN02541.1Hypothetical protein. (107 aa)
rpsDSSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (203 aa)
rpmILSU ribosomal protein L35P; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
rplTLSU ribosomal protein L20P; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (128 aa)
SDM87273.1Predicted kinase, aminoglycoside phosphotransferase (APT) family. (340 aa)
rpsTSmall subunit ribosomal protein S20; Binds directly to 16S ribosomal RNA. (88 aa)
rpmG-2Large subunit ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (54 aa)
rplKLSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (144 aa)
rplALSU ribosomal protein L1P; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (240 aa)
rplJLSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (176 aa)
rplLLSU ribosomal protein L12P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (127 aa)
rpsLSSU ribosomal protein S12P; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (123 aa)
rpsGSSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsJSSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rplCLSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (214 aa)
rplDLarge subunit ribosomal protein L4; Forms part of the polypeptide exit tunnel. (216 aa)
rplWLarge subunit ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (104 aa)
rplBLSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (278 aa)
rpsSSSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
rplVLSU ribosomal protein L22P; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (115 aa)
rpsCSSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (278 aa)
rplPLSU ribosomal protein L16P; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (139 aa)
rpmCLSU ribosomal protein L29P; Belongs to the universal ribosomal protein uL29 family. (74 aa)
rpsQSSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (94 aa)
rplNLSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplXLSU ribosomal protein L24P; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (107 aa)
rplELSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (185 aa)
rpsZSSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rpsHSSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rplFLSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (179 aa)
rplRLarge subunit ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (127 aa)
rpsESSU ribosomal protein S5P; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (203 aa)
rpmDLSU ribosomal protein L30P. (60 aa)
rpmJ-2Large subunit ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (47 aa)
rpsMSSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (126 aa)
rpsKSSU ribosomal protein S11P; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (134 aa)
rplQLarge subunit ribosomal protein L17. (164 aa)
rplMLSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (147 aa)
rpsISmall subunit ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (172 aa)
rplYLarge subunit ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (201 aa)
SDM60802.1Hypothetical protein. (230 aa)
rpmHLSU ribosomal protein L34P; Belongs to the bacterial ribosomal protein bL34 family. (45 aa)
rpsFSSU ribosomal protein S6P; Binds together with S18 to 16S ribosomal RNA. (96 aa)
rpsRSSU ribosomal protein S18P; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (78 aa)
rplILSU ribosomal protein L9P; Binds to the 23S rRNA. (148 aa)
rpmJLarge subunit ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (40 aa)
rpmGLarge subunit ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (54 aa)
rplULSU ribosomal protein L21P; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (106 aa)
rpmALSU ribosomal protein L27P; Belongs to the bacterial ribosomal protein bL27 family. (84 aa)
SDM30282.1Yip1 domain-containing protein. (340 aa)
rpsBSSU ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family. (299 aa)
rplSLSU ribosomal protein L19P; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (116 aa)
rpsPSmall subunit ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (146 aa)
rpmF-2LSU ribosomal protein L32P; Belongs to the bacterial ribosomal protein bL32 family. (57 aa)
rpmBLSU ribosomal protein L28P; Belongs to the bacterial ribosomal protein bL28 family. (61 aa)
SDM20926.1Phosphotransferase enzyme family protein. (327 aa)
SDM12706.1SSU ribosomal protein S1P. (497 aa)
rpmFLarge subunit ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (56 aa)
Your Current Organism:
Streptomyces wuyuanensis
NCBI taxonomy Id: 1196353
Other names: CGMCC 4.7042, KCTC 29112, S. wuyuanensis, Streptomyces sp. FX61, Streptomyces wuyuanensis Zhang et al. 2013, strain FX61
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