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| | acsA-2 | Acetyl-coenzyme A synthetase. (654 aa) |
| | ACAM_0764 | Nucleotidyl transferase. (363 aa) |
| | ACAM_0766 | acyl-CoA dehydrogenase. (395 aa) |
| | ACAM_0809 | Nicotinate phosphoribosyltransferase. (390 aa) |
| | ACAM_0812 | Pyrimidine nucleotide reductase. (220 aa) |
| | acsA | Acetyl-coenzyme A synthetase. (657 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (146 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (147 aa) |
| | ACAM_0885 | Hypothetical protein. (346 aa) |
| | ACAM_0927 | GTP cyclohydrolase I. (101 aa) |
| | ACAM_0928 | 2-oxoglutarate ferredoxin oxidoreductase subunit. (309 aa) |
| | ACAM_0929 | 2-oxoacid:ferredoxin oxidoreductase alpha. (642 aa) |
| | sirC | Precorrin-2 dehydrogenase. (220 aa) |
| | hemD | uroporphyrinogen-III synthase. (240 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase. (432 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (538 aa) |
| | ACAM_1023 | Hypothetical protein. (78 aa) |
| | ACAM_1036 | PqqE-like protein. (389 aa) |
| | ACAM_1037 | PqqE-like protein. (403 aa) |
| | pyrI | Aspartate carbamoyltransferase regulatory; Involved in allosteric regulation of aspartate carbamoyltransferase. (159 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic. (312 aa) |
| | pdhB | Pyruvate dehydrogenase E1 subunit beta. (325 aa) |
| | pdhA | Pyruvate dehydrogenase E1 subunit alpha. (420 aa) |
| | ACAM_1050 | acyl-CoA dehydrogenase. (389 aa) |
| | ACAM_1060 | Cytochrome AA3 controlling protein. (150 aa) |
| | ACAM_1062 | Hypothetical protein. (115 aa) |
| | rpoD | DNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. (286 aa) |
| | rpoN | DNA-directed RNA polymerase subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (77 aa) |
| | ACAM_1105 | Adenylate cyclase class 2. (177 aa) |
| | ACAM_1144 | Uncharacterized conserved protein. (376 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (309 aa) |
| | nusA | Transcription elongation factor NusA-like; Participates in transcription termination. Belongs to the NusA family. (144 aa) |
| | rpoA2 | DNA-directed RNA polymerase subunit A'; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (407 aa) |
| | rpoA1 | DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (891 aa) |
| | rpoB | DNA-directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1170 aa) |
| | rpoH | DNA-directed RNA polymerase subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (90 aa) |
| | tbp | Transcription factor; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (203 aa) |
| | ctaB | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (305 aa) |
| | mtnP | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (275 aa) |
| | ACAM_1211 | Uncharacterized protein conserved in archaea. (261 aa) |
| | ACAM_1212 | Predicted archaeal kinase. (279 aa) |
| | nadE | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (285 aa) |
| | dfp | Coenzyme A biosynthesis bifunctional protein. (412 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (460 aa) |
| | ACAM_1244 | Competence damage-inducible protein A; Belongs to the CinA family. (268 aa) |
| | nadM-2 | Nicotinamide-nucleotide adenylyltransferase. (186 aa) |
| | tfe | Transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...] (189 aa) |
| | ACAM_1285 | B12-dependent ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (979 aa) |
| | thyX | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (324 aa) |
| | ACAM_1292 | Purine phosphoribosyltransferase. (273 aa) |
| | tmk | Thymidylate kinase. (209 aa) |
| | ACAM_1312 | Predicted nucleotide kinase. (197 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (431 aa) |
| | ACAM_1314 | DNA polymerase II. (803 aa) |
| | udp | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (282 aa) |
| | ACAM_1321 | Uncharacterized conserved protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (248 aa) |
| | ribK | Transcriptional regulator of a riboflavin/FAD biosynthetic operon; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (132 aa) |
| | ACAM_1331 | 2-oxoacid:ferredoxin oxidoreductase subunit alpha. (639 aa) |
| | ACAM_1332 | 2-oxoglutarate ferredoxin oxidoreductase subunit beta. (318 aa) |
| | hemL | Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (430 aa) |
| | thi4 | Ribulose-1,5-biphosphate synthetase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (273 aa) |
| | ACAM_1354 | acyl-CoA dehydrogenase. (399 aa) |
| | ACAM_1397 | DNA polymerase II. (636 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (429 aa) |
| | hemC | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (307 aa) |
| | hemL-2 | Glutamate-1-semialdehyde aminotransferase. (432 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (353 aa) |
| | mptA | Uncharacterized conserved protein; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. (283 aa) |
| | trpB | Tryptophan synthase subunit beta. (356 aa) |
| | trpB-2 | Tryptophan synthase subunit beta. (75 aa) |
| | ACAM_1456 | Hypothetical protein. (244 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (293 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (239 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (186 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (141 aa) |
| | thiDN | Phosphomethylpyrimidine kinase. (460 aa) |
| | tfb-2 | Transcription initiation factor IIB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (322 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (512 aa) |
| | ACAM_1581 | Acetolactate synthase; Belongs to the TPP enzyme family. (558 aa) |
| | ACAM_0028 | Indole-3-glycerol phosphate synthase. (219 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (220 aa) |
| | ACAM_0030 | Pyridoxal-phosphate dependent TrpB-like enzyme. (426 aa) |
| | ACAM_0031 | Tryptophan synthase alpha chain. (218 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (349 aa) |
| | ACAM_0033 | Anthranilate/para-aminobenzoate synthase component I. (438 aa) |
| | ACAM_0046 | Adenine/guanine phosphoribosyltransferase. (233 aa) |
| | dut | Deoxyuridine 5'-triphosphate. (159 aa) |
| | mogA | Molybdopterin biosynthesis protein MogA. (161 aa) |
| | ACAM_0076 | DNA polymerase I. (984 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (279 aa) |
| | ACAM_0124 | 5-formyltetrahydrofolate cyclo-ligase. (246 aa) |
| | ACAM_0130 | ATP:cobalamin adenosyltransferase. (180 aa) |
| | moeA | Molybdopterin biosynthesis protein MoeA. (386 aa) |
| | ACAM_0138 | Molybdopterin-guanine dinucleotide biosynthesis protein. (140 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis. (282 aa) |
| | ACAM_0158 | Uncharacterized Zn-finger containing protein. (129 aa) |
| | thiL | Thiamine-monophosphate kinase. (310 aa) |
| | cobA | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (249 aa) |
| | ACAM_0181 | Uncharacterized conserved protein. (211 aa) |
| | pdxT | Glutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (203 aa) |
| | pdxS | Pyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (353 aa) |
| | ACAM_0194 | Uncharacterized protein conserved in archaea; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (182 aa) |
| | rpoE1 | DNA-directed RNA polymerase subunit E'. (186 aa) |
| | pyrD | Dihydroorotate dehydrogenase 1B; Catalyzes the conversion of dihydroorotate to orotate. (307 aa) |
| | pyrC | Dihydroorotase. (426 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (178 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (226 aa) |
| | atpD | V-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (211 aa) |
| | aptB | V-type ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (463 aa) |
| | atpA | V-type ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (597 aa) |
| | atpE | V-type ATP synthase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (200 aa) |
| | priA | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (342 aa) |
| | tfs | Transcription factor S; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (120 aa) |
| | rpoL | DNA-directed RNA polymerase subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. (99 aa) |
| | moeA-2 | Molybdopterin biosynthesis protein MoeA. (566 aa) |
| | thiI | Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (396 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (367 aa) |
| | ACAM_0382 | Purine phosphoribosyltransferase. (229 aa) |
| | ACAM_0393 | Transcription initiation factor TFIIB. (201 aa) |
| | nadM | Nicotinamide-nucleotide adenylyltransferase. (174 aa) |
| | upp | Uracil phosphoribosyltransferase. (213 aa) |
| | rpoF | DNA-directed RNA polymerase subunit F. (113 aa) |
| | ACAM_0438 | Transketolase. (322 aa) |
| | ACAM_0439 | Transketolase. (252 aa) |
| | ACAM_0463 | Molybdopterin converting factor. (246 aa) |
| | ACAM_0474 | Uncharacterized Zn ribbon-containing protein. (111 aa) |
| | priB | DNA primase large subunit. (339 aa) |
| | panB | 3-methyl-2-oxobutanoate; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (274 aa) |
| | panE | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (309 aa) |
| | ACAM_0526 | acyl-CoA dehydrogenase. (331 aa) |
| | ACAM_0548 | Predicted nucleotide kinase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (215 aa) |
| | tfb | Transcription initiation factor IIB. (303 aa) |
| | rpoK | DNA-directed RNA polymerase subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (103 aa) |
| | hxlA | Hexulose-6-phosphate synthase. (240 aa) |
| | ACAM_0625 | Putative amidase. (239 aa) |
| | cmk | Cytidylate kinase. (172 aa) |
| | adkA | Adenylate kinase; Belongs to the archaeal adenylate kinase family. (202 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase. (238 aa) |
| | ribC | Riboflavin synthase. (155 aa) |
| | ACAM_0665 | Transcription elongation factor. (90 aa) |
| | ACAM_0697 | Adenine/guanine phosphoribosyltransferase. (213 aa) |
| | lig | ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (603 aa) |
| | ppnK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (291 aa) |
| | ACAM_0762 | Nucleotidyl transferase. (415 aa) |
