(16 nodes) Propanoate metabolism network (Aeropyrum camini)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	prpB	Carboxyvinyl-carboxyphosphonate; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (308 aa)
	ACAM_0333	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa)
	ACAM_0606	acetyl-CoA acetyltransferase. (397 aa)
	sucC	succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (378 aa)
	sucD	succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa)
	acsA	Acetyl-coenzyme A synthetase. (657 aa)
	pdhD	Dihydrolipoyl dehydrogenase. (464 aa)
	ACAM_1052	Coenzyme B12-dependent mutase. (161 aa)
	ACAM_1053	Coenzyme B12-dependent mutase. (565 aa)
	gltA	Citrate synthase. (394 aa)
	ACAM_1319	acetyl-CoA acetyltransferase. (406 aa)
	prpD	2-methylcitrate dehydratase. (458 aa)
	ACAM_1496	acetyl-CoA acetyltransferase. (385 aa)
	ACAM_1497	acetyl-CoA acetyltransferase. (394 aa)
	ACAM_1553	Propionate CoA-transferase. (554 aa)
	acsA-2	Acetyl-coenzyme A synthetase. (654 aa)

Your Current Organism:

Aeropyrum camini

NCBI taxonomy Id: 1198449
Other names: A. camini SY1 = JCM 12091, Aeropyrum camini JCM 12091, Aeropyrum camini JCM 12091 = SY1, Aeropyrum camini SY1, Aeropyrum camini SY1 = JCM 12091

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAM_0606	ACAM_1319	ACAM_0606	ACAM_1319	acetyl-CoA acetyltransferase.	acetyl-CoA acetyltransferase.	0.917
ACAM_0606	ACAM_1496	ACAM_0606	ACAM_1496	acetyl-CoA acetyltransferase.	acetyl-CoA acetyltransferase.	0.925
ACAM_0606	ACAM_1497	ACAM_0606	ACAM_1497	acetyl-CoA acetyltransferase.	acetyl-CoA acetyltransferase.	0.915
ACAM_0606	ACAM_1553	ACAM_0606	ACAM_1553	acetyl-CoA acetyltransferase.	Propionate CoA-transferase.	0.918
ACAM_0606	acsA	ACAM_0606	ACAM_0851	acetyl-CoA acetyltransferase.	Acetyl-coenzyme A synthetase.	0.948
ACAM_0606	acsA-2	ACAM_0606	ACAM_1633	acetyl-CoA acetyltransferase.	Acetyl-coenzyme A synthetase.	0.955
ACAM_0606	gltA	ACAM_0606	ACAM_1071	acetyl-CoA acetyltransferase.	Citrate synthase.	0.457
ACAM_0606	prpB	ACAM_0606	ACAM_0170	acetyl-CoA acetyltransferase.	Carboxyvinyl-carboxyphosphonate; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.	0.853
ACAM_0606	sucC	ACAM_0606	ACAM_0693	acetyl-CoA acetyltransferase.	succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.853
ACAM_0606	sucD	ACAM_0606	ACAM_0694	acetyl-CoA acetyltransferase.	succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.863
ACAM_1052	ACAM_1053	ACAM_1052	ACAM_1053	Coenzyme B12-dependent mutase.	Coenzyme B12-dependent mutase.	0.999
ACAM_1052	sucC	ACAM_1052	ACAM_0693	Coenzyme B12-dependent mutase.	succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.933
ACAM_1052	sucD	ACAM_1052	ACAM_0694	Coenzyme B12-dependent mutase.	succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.944
ACAM_1053	ACAM_1052	ACAM_1053	ACAM_1052	Coenzyme B12-dependent mutase.	Coenzyme B12-dependent mutase.	0.999
ACAM_1053	sucC	ACAM_1053	ACAM_0693	Coenzyme B12-dependent mutase.	succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.930
ACAM_1053	sucD	ACAM_1053	ACAM_0694	Coenzyme B12-dependent mutase.	succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.935
ACAM_1319	ACAM_0606	ACAM_1319	ACAM_0606	acetyl-CoA acetyltransferase.	acetyl-CoA acetyltransferase.	0.917
ACAM_1319	ACAM_1496	ACAM_1319	ACAM_1496	acetyl-CoA acetyltransferase.	acetyl-CoA acetyltransferase.	0.900
ACAM_1319	ACAM_1497	ACAM_1319	ACAM_1497	acetyl-CoA acetyltransferase.	acetyl-CoA acetyltransferase.	0.900
ACAM_1319	ACAM_1553	ACAM_1319	ACAM_1553	acetyl-CoA acetyltransferase.	Propionate CoA-transferase.	0.918

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