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| | fbaA1 | Fructose-bisphosphate aldolase, class I; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (263 aa) |
| | fbaA3 | Fructose-bisphosphate aldolase, class I; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (260 aa) |
| | aroB | Dehydroquinate synthase II; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (328 aa) |
| | tyrA | Prephenate dehydrogenase, NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; High confidence in function and specificity. (274 aa) |
| | pheA | Prephenate dehydratase, ACT domain; High confidence in function and specificity. (264 aa) |
| | cobD | Adenosylcobinamide-phosphate synthase CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (306 aa) |
| | pdxS | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (299 aa) |
| | BN140_0054 | Hypothetical protein. (413 aa) |
| | thrC1 | Threonine synthase; Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate. (430 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (328 aa) |
| | argJ | Ornithine acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (379 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (289 aa) |
| | BN140_0079 | Chorismate mutase. (94 aa) |
| | nadB | Aspartate kinase; Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; Hypothetical protein; Belongs to the aspartokinase family. (462 aa) |
| | phhB | Transcriptional coactivator/pterin dehydratase, Pterin 4 alpha carbinolamine dehydratase; High confidence in function and specificity. (115 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (282 aa) |
| | mptE | Hypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. (207 aa) |
| | cofH1 | FO synthase, subunit 2-like, Radical SAM superfamily; High confidence in function and specificity. (362 aa) |
| | gltS | Glutamate synthase, central-C, Conserved region in glutamate synthase; High confidence in function and specificity. (529 aa) |
| | ribD | 5-amino-6-(5- phosphoribosylamino)uracilreductase; 2, 5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase, archaeal; High confidence in function and specificity. (226 aa) |
| | trpF1 | N-(5'phosphoribosyl)anthranilate isomerase (PRAI), N-(5'phosphoribosyl)anthranilate (PRA) isomerase; High confidence in function and specificity; Belongs to the TrpF family. (220 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (121 aa) |
| | cobQ | Adenosylcobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (497 aa) |
| | leuC1 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (417 aa) |
| | leuD1 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | leuB1 | 3-isopropylmalate dehydrogenase; High confidence in function and specificity. (373 aa) |
| | BN140_0371 | Hypothetical protein; 4Fe-4S ferredoxin, iron-sulpur binding domain. (218 aa) |
| | BN140_0417 | Iron-sulfur cluster-binding protein; 4Fe-4S ferredoxin, iron-sulpur binding domain; Hypothetical protein. (260 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (288 aa) |
| | gpi1 | Glucose-6-phosphate isomerase, prokaryote; High confidence in function and specificity. (240 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (430 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (422 aa) |
| | BN140_0472 | Aspartate transaminase; Diaminopimelate aminotransferase, DapL, Desulfovibrio-type, Aminotransferase class I and II; High confidence in function and specificity. (382 aa) |
| | hisC1 | Histidinol-phosphate aminotransferase, Allinase; High confidence in function and specificity. (352 aa) |
| | argD | acetylornithine/N- succinyldiaminopimelateaminotransferase; 2.6.1.17], Acetylornithine/Succinylornithine aminotransferase, Aminotransferase class-III; High confidence in function and specificity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (374 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (416 aa) |
| | ppsA1 | Pyruvate, water dikinase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (768 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (183 aa) |
| | purC | Phosphoribosylaminoimidazole- succinocarboxamidesynthase; SAICAR synthetase; High confidence in function and specificity. (241 aa) |
| | cofG | FO synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (328 aa) |
| | dhpS | Dihydropteroate synthase, Pterin binding enzyme; High confidence in function and specificity. (271 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa) |
| | uppS | Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids. (255 aa) |
| | BN140_0602 | Undecaprenyl pyrophosphate synthetase; Di-trans-poly-cis-decaprenylcistransferase-like, putative undecaprenyl diphosphate synthase; High confidence in function and specificity. (196 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphohydrolase; High confidence in function and specificity. (97 aa) |
| | BN140_0617 | Metallo-beta-lactamase superfamily protein; Beta-lactamase-like; Hypothetical protein. (220 aa) |
| | thrC3 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (400 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (289 aa) |
| | cobB | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (456 aa) |
| | cbiX | Sirohydrochlorin cobaltochelatase; Cobalamin (vitamin B12) biosynthesis CbiX, Ferrochelatase; High confidence in function and specificity. (130 aa) |
| | BN140_0751 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (350 aa) |
| | leuA1 | 2-isopropylmalate synthase; Pyruvate carboxyltransferase; High confidence in function and specificity; Belongs to the alpha-IPM synthase/homocitrate synthase family. (519 aa) |
| | hisA1 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Histidine biosynthesis protein; High confidence in function and specificity; Belongs to the HisA/HisF family. (238 aa) |
| | thiI | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (400 aa) |
| | apbA | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (305 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (439 aa) |
| | nadA | Quinolinate synthetase A, Thiamine pyrophosphate enzyme, central domain; High confidence in function and specificity. (297 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; High confidence in function and specificity. (193 aa) |
| | hisA3 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, Histidine biosynthesis protein; High confidence in function and specificity. (239 aa) |
| | hisG1 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (297 aa) |
| | argH | Argininosuccinate lyase, Protein of unknown function (DUF1454); High confidence in function and specificity. (492 aa) |
| | hypE1 | Predicted nickel metalloenzyme maturation factor, AIR synthase-related, Minichromosone maintenance protein 2; High confidence in function and specificity. (442 aa) |
| | thiD | Phosphomethylpyrimidine kinase type-2, Carbohydrate kinase; High confidence in function and specificity. (261 aa) |
| | cobS | adenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (236 aa) |
| | cobT | Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, putative; High confidence in function and specificity; Belongs to the UPF0284 family. (338 aa) |
| | mtaP | 5'-deoxy-5'-methylthioadenosine phosphorylase; High confidence in function and specificity. (223 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the formation of aspartate semialdehyde from aspartyl phosphate; High confidence in function and specificity. (338 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (252 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (291 aa) |
| | argE | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase; High confidence in function and specificity. (389 aa) |
| | BN140_1191 | 5-amino-6-(5- phosphoribosylamino)uracilreductase; Riboflavin-specific deaminase, C-terminal, RibD C-terminal domain; High confidence in function and specificity. (232 aa) |
| | BN140_1266 | Phosphatases; Haloacid dehalogenase-like hydrolase; Conserved hypothetical protein. (231 aa) |
| | thiC1 | Thiamine biosynthesis protein thiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (424 aa) |
| | fbpA | Fructose-1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (365 aa) |
| | ubiD | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Carboxylyase-related; High confidence in function and specificity. (413 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Methionine synthase, vitamin-B12 independent, Cobalamin-independent synthase, N-terminal domain; High confidence in function and specificity. (300 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (272 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa) |
| | BN140_1394 | Putative hydrolase of the HAD superfamily; Haloacid dehalogenase-like hydrolase; Hypothetical protein. (220 aa) |
| | BN140_1401 | Beta-lactamase domain protein; Beta-lactamase-like; Specificity unclear. (279 aa) |
| | BN140_1428 | Hexapaptide repeat-containing transferase; Hexapeptide transferase, conserved site, Bacterial transferase hexapeptide (three repeats), O-acetyltransferase NeuD family; Hypothetical protein. (197 aa) |
| | queC | Queuosine biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (221 aa) |
| | queE | Putative 7-cyano-7-deazaguanosine biosynthesis protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (202 aa) |
| | queD | 6-pyruvoyl tetrahydropterin synthase; High confidence in function and specificity. (137 aa) |
| | thi1 | Thiamine biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (254 aa) |
| | cofH3 | 7, 8-didemethyl-8-hydroxy-5-deazariboflavinsynthase; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (376 aa) |
| | thiC3 | Thiamine biosynthesis protein ThiC, ThiC family; High confidence in function and specificity. (438 aa) |
| | aspC3 | Aminotransferase, class V/Cysteine desulfurase, Aminotransferase class-V; High confidence in function and specificity. (377 aa) |
| | ribC | Riboflavin synthase, archaeal, 6,7-dimethyl-8-ribityllumazine synthase; High confidence in function and specificity. (153 aa) |
| | ribH | Riboflavin synthase beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (135 aa) |
| | trpB2 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (452 aa) |
| | trpE | Anthranilate synthase component I; Chorismate binding, C-terminal; High confidence in function and specificity. (419 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; High confidence in function and specificity; Belongs to the TrpC family. (251 aa) |
| | trpF3 | N-(5'phosphoribosyl)anthranilate (PRA) isomerase; High confidence in function and specificity; Belongs to the TrpF family. (190 aa) |
| | trpB1 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (389 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa) |
| | glnA1 | Glutamine synthetase, catalytic domain; High confidence in function and specificity. (443 aa) |
| | BN140_1564 | Glutamate synthase (NADPH/NADH) large chain; 1.4.1.14], Glutamate synthase, central-C, Conserved region in glutamate synthase; High confidence in function and specificity; Belongs to the glutamate synthase family. (505 aa) |
| | cbiT | precorrin-8W decarboxylase; Cobalamin biosynthesis, precorrin-6Y methyltransferase, CbiT subunit, Methyltransferase domain; High confidence in function and specificity. (176 aa) |
| | cbiL | 2.1.1.151], Cobalamin (vitamin B12) biosynthesis CobI/CbiL, precorrin-2 C20-methyltransferase; High confidence in function and specificity. (205 aa) |
| | cbiF | Precorrin-4 C11-methyltransferase; Tetrapyrrole methylase, Radical SAM superfamily; High confidence in function and specificity; Belongs to the precorrin methyltransferase family. (238 aa) |
| | cbiG | Cobalamin (vitamin B12) biosynthesis CbiG, core, Cobalamin synthesis G N-terminal; Conserved hypothetical protein. (290 aa) |
| | cbiH | Cobalamin (vitamin B12) biosynthesis CobJ/CibH, precorrin-3B C17-methyltransferase, core; High confidence in function and specificity. (264 aa) |
| | cbiD | cobalt-precorrin-6A synthase; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (338 aa) |
| | cbiE | Cobalamin (vitamin B12) biosynthesis CbiE, precorrin-6Y methyltransferase, core; High confidence in function and specificity. (190 aa) |
| | BN140_1603 | Beta-lactamase-like; Conserved hypothetical protein. (241 aa) |
| | asnB1 | Asparagine synthase, glutamine-hydrolyzing, Glutamine amidotransferases class-II; High confidence in function and specificity. (600 aa) |
| | BN140_1632 | Rhodanese-related sulfurtransferase; Rhodanese-like; High confidence in function and specificity. (139 aa) |
| | hemD | Tetrapyrrole biosynthesis, uroporphyrinogen III synthase, Uroporphyrinogen-III synthase HemD; High confidence in function and specificity. (226 aa) |
| | hisF | Cyclase HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (268 aa) |
| | leuD3 | 4.2.1.35], 3-isopropylmalate dehydratase, small subunit, subgroup, Aconitate hydratase 2 N-terminus; High confidence in function and specificity. (157 aa) |
| | leuC3 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (403 aa) |
| | aksA | 2-isopropylmalate synthase; Pyruvate carboxyltransferase; High confidence in function and specificity; Belongs to the alpha-IPM synthase/homocitrate synthase family. (376 aa) |
| | BN140_1803 | Hypothetical protein. (135 aa) |
| | BN140_1804 | Asparagine synthase family amidotransferase; High confidence in function and specificity. (263 aa) |
| | BN140_1854 | Hypothetical protein; High confidence in function and specificity. (502 aa) |
| | BN140_1855 | NADH-plastoquinone oxidoreductase; 4Fe-4S ferredoxin, iron-sulpur binding domain, NIL domain; Hypothetical protein. (132 aa) |
| | BN140_1902 | Homoserine dehydrogenase, catalytic, Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; High confidence in function and specificity. (329 aa) |
| | BN140_1905 | Myo-inositol-1-phosphate synthase; High confidence in function and specificity. (367 aa) |
| | ilvD | Dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family. (551 aa) |
| | carA | Carbamoyl-phosphate synthase, small subunit, Glutamine amidotransferase class-I; High confidence in function and specificity; Belongs to the CarA family. (351 aa) |
| | carB | Carbamoyl-phosphate synthase, large subunit, MGS-like domain; High confidence in function and specificity; Belongs to the CarB family. (1055 aa) |
| | argG | Argininosuccinate synthase, type 1 subfamily, ArgK protein; High confidence in function and specificity; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (395 aa) |
| | argF | Ornithine carbamoyltransferase, Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; High confidence in function and specificity; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (309 aa) |
| | aroK1 | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (451 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (332 aa) |
| | aroD | 3-dehydroquinate dehydratase I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (209 aa) |
| | proG | Competence protein ComER; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (266 aa) |
| | gpi3 | Glucose-6-phosphate isomerase, prokaryote; High confidence in function and specificity. (232 aa) |
| | ppsA3 | Pyruvate, water dikinase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (812 aa) |
| | ldhA | D-lactate dehydrogenase; NADP oxidoreductase coenzyme F420-dependent; High confidence in function and specificity; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (352 aa) |
| | gpmA | Phosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (248 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (202 aa) |
| | BN140_2221 | Phosphoserine phosphatase; High confidence in function and specificity. (286 aa) |
| | cobY | 5-deoxyadenosylcobinamide phosphate nucleotidyltransferase; Diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; High confidence in function and specificity. (201 aa) |
| | BN140_2246 | Fructose-bisphosphate aldolase, class I; DeoC/LacD family aldolase; High confidence in function and specificity. (306 aa) |
| | leuA3 | D-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (503 aa) |
| | ilvH | Acetolactate synthase, small subunit, Small subunit of acetolactate synthase; High confidence in function and specificity. (167 aa) |
| | BN140_2303 | alpha-L-glutamate ligase; ATP-grasp fold, RimK-type; Conserved hypothetical protein. (264 aa) |
| | asnB3 | Asparagine synthase; High confidence in function and specificity. (323 aa) |
| | glnA3 | Glutamine synthetase, catalytic domain; High confidence in function and specificity. (501 aa) |
| | BN140_2438 | Hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (274 aa) |
| | aroK3 | Shikimate kinase; High confidence in function and specificity. (225 aa) |
| | cbiA | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (454 aa) |
| | cbiM | Cobalt transport protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (230 aa) |
| | cbiN | Cobalt transport protein cbiN; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (96 aa) |
| | BN140_2472 | Hydroxyacylglutathione hydrolase; Beta-lactamase-like, Rhodanese-like domain; High confidence in function and specificity. (468 aa) |
| | ribB | 3,4-dihydroxy 2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (226 aa) |
| | ribK | Riboflavin kinase, archaea type; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (263 aa) |
| | hisG5 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (290 aa) |
| | panE | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (314 aa) |
| | thiC5 | Thiamine biosynthesis protein ThiC, Protein of unknown function (DUF1498); High confidence in function and specificity. (455 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase, type II, C-terminal domain; High confidence in function and specificity. (341 aa) |
| | BN140_3022 | Hypothetical protein. (142 aa) |
| | cbiC | precorrin-8X methylmutase. (226 aa) |
| | leuB3 | 3-isopropylmalate dehydrogenase. (322 aa) |
| | BN140_3053 | Maltose O-acyltransferase. (177 aa) |
| | BN140_3055 | 4'-phosphopantetheinyl transferase. (121 aa) |
| | ubiA3 | 1,4-dihydroxy-2-naphtoate prenyltransferase; Hypothetical protein. (307 aa) |
| | pycA | Pyruvate carboxylase subunit A; Biotin carboxylation domain, Carbamoyl-phosphate synthase L chain, N-terminal domain; High confidence in function and specificity. (491 aa) |
| | cobO | cob(I)yrinic acid a,c-diamide adenosyltransferase; Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR, ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; High confidence in function and specificity. (171 aa) |
| | BN140_2004 | GMP synthase (glutamine-hydrolyzing); Glutamine amidotransferase type 1; Conserved hypothetical protein. (187 aa) |
| | tpiA | Triosephosphate isomerase (TIM); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (222 aa) |
