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sdhB sdhB mch1 mch1 BN140_0145 BN140_0145 cobB cobB BN140_0718 BN140_0718 BN140_0719 BN140_0719 cbiX cbiX BN140_0744 BN140_0744 BN140_0750 BN140_0750 hdrA1 hdrA1 mdhA mdhA sucD sucD sucC sucC fwdD1 fwdD1 fwdB1 fwdB1 fwdC1 fwdC1 frhA frhA ppcA ppcA mcrA1 mcrA1 mcrG1 mcrG1 mcrD1 mcrD1 mcrB1 mcrB1 fwdD3 fwdD3 fwdB3 fwdB3 fwdC3 fwdC3 echA echA echF echF mer mer mtd mtd ftr ftr BN140_1724 BN140_1724 hdrC hdrC hdrB hdrB hdrA3 hdrA3 fwdD5 fwdD5 fwdB5 fwdB5 fwdC5 fwdC5 mcrB3 mcrB3 mcrD3 mcrD3 mcrC mcrC mcrG3 mcrG3 mcrA3 mcrA3 mtrE mtrE mtrD mtrD mtrC mtrC mtrB mtrB mtrA1 mtrA1 mtrF mtrF mtrA2 mtrA2 mtrH mtrH mch3 mch3 mvhA mvhA BN140_1868 BN140_1868 gltD gltD acsC acsC acsD acsD acsB acsB BN140_2473 BN140_2473 ldh ldh
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sdhBSuccinate dehydrogenase and fumarate reductase iron-sulfur protein; Hypothetical protein. (487 aa)
mch1Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (314 aa)
BN140_0145Fe-S oxidoreductase; Cysteine-rich domain; Hypothetical protein. (362 aa)
cobBCobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (456 aa)
BN140_0718Hypothetical protein; Putative methanogenesis marker 13 metalloprotein, Nitrogenase component 1 type Oxidoreductase; High confidence in function and specificity. (354 aa)
BN140_0719Hypothetical protein; Uroporphyrinogen-III synthase HemD; High confidence in function and specificity. (386 aa)
cbiXSirohydrochlorin cobaltochelatase; Cobalamin (vitamin B12) biosynthesis CbiX, Ferrochelatase; High confidence in function and specificity. (130 aa)
BN140_0744Acyl-CoA synthetase (NDP forming); CoA-binding, ATP-grasp domain; High confidence in function and specificity. (680 aa)
BN140_0750Protein of unknown function DUF116; Specificity unclear. (234 aa)
hdrA1Heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (424 aa)
mdhAL-lactate/malate dehydrogenase, lactate/malate dehydrogenase, NAD binding domain; High confidence in function and specificity; Belongs to the LDH/MDH superfamily. (288 aa)
sucDsuccinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (288 aa)
sucCSuccinyl-CoA synthetase, beta subunit, ATP-grasp domain; High confidence in function and specificity. (361 aa)
fwdD1Formylmethanofuran dehydrogenase, subunit D, Molydopterin dinucleotide binding domain; High confidence in function and specificity. (129 aa)
fwdB1Formylmethanofuran dehydrogenase, subunit B, Molybdopterin oxidoreductase; High confidence in function and specificity. (429 aa)
fwdC1Formylmethanofuran dehydrogenase subunit C, Septum formation inhibitor MinC, C-terminal domain; High confidence in function and specificity. (256 aa)
frhACoenzyme F420 hydrogenase, subunit alpha, Nickel-dependent hydrogenase; High confidence in function and specificity; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (455 aa)
ppcAPhosphoenolpyruvate carboxylase; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (485 aa)
mcrA1Methyl-coenzyme M reductase alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (568 aa)
mcrG1Methyl-coenzyme M reductase, gamma subunit; High confidence in function and specificity. (254 aa)
mcrD1Methyl-coenzyme M reductase operon protein D; Specificity unclear. (199 aa)
mcrB1Methyl-coenzyme M reductase, beta subunit; High confidence in function and specificity. (434 aa)
fwdD3Formylmethanofuran dehydrogenase subunit D; Molydopterin dinucleotide binding domain; High confidence in function and specificity. (113 aa)
fwdB3Formylmethanofuran dehydrogenase, subunit B, Molybdopterin oxidoreductase; High confidence in function and specificity. (455 aa)
fwdC3Formylmethanofuran dehydrogenase subunit C; High confidence in function and specificity. (266 aa)
echANADH dehydrogenase (quinone); NADH:ubiquinone/plastoquinone oxidoreductase; High confidence in function and specificity. (633 aa)
echFFormate hydrogenlyase; 4Fe-4S ferredoxin, iron-sulpur binding domain; Hypothetical protein. (132 aa)
merCoenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (330 aa)
mtdMethylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (280 aa)
ftrFormylmethanofuran-tetrahydromethanopterin N-formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (302 aa)
BN140_1724Hypothetical protein; 4Fe-4S ferredoxin, iron-sulpur binding domain; High confidence in function and specificity. (90 aa)
hdrCCoB-CoM heterodisulphide reductase, subunit C, 4Fe-4S binding domain; High confidence in function and specificity. (193 aa)
hdrBCoB-CoM heterodisulphide reductase, subunit B; High confidence in function and specificity. (299 aa)
hdrA3Heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (674 aa)
fwdD5Formylmethanofuran dehydrogenase, subunit D, Molydopterin dinucleotide binding domain; High confidence in function and specificity. (133 aa)
fwdB5Formylmethanofuran dehydrogenase, subunit B, Molybdopterin oxidoreductase; High confidence in function and specificity. (437 aa)
fwdC5Formylmethanofuran dehydrogenase subunit C; High confidence in function and specificity. (268 aa)
mcrB3Ulfoethylthiotransferase beta, Methyl-coenzyme M reductase, beta subunit; High confidence in function and specificity. (434 aa)
mcrD3Methyl-coenzyme M reductase, protein D; Specificity unclear. (158 aa)
mcrCMethyl-coenzyme M reductase operon protein C; High confidence in function and specificity. (207 aa)
mcrG3Sulfoethylthiotransferase gamma;, Methyl-coenzyme M reductase, gamma subunit; High confidence in function and specificity. (253 aa)
mcrA3Methyl-coenzyme M reductase alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (568 aa)
mtrETetrahydromethanopterin S-methyltransferase subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (299 aa)
mtrDTetrahydromethanopterin S-methyltransferase subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (283 aa)
mtrCTetrahydromethanopterin S-methyltransferase subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (283 aa)
mtrBTetrahydromethanopterin S-methyltransferase subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (94 aa)
mtrA1Tetrahydromethanopterin S-methyltransferase subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (241 aa)
mtrFTetrahydromethanopterin S-methyltransferase, F subunit; Specificity unclear. (70 aa)
mtrA2Tetrahydromethanopterin S-methyltransferase subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (246 aa)
mtrHTetrahydromethanopterin S-methyltransferase, MtrH subunit; High confidence in function and specificity. (345 aa)
mch3Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (315 aa)
mvhANickel-dependent hydrogenase, large subunit; High confidence in function and specificity; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (454 aa)
BN140_1868Metallophosphoesterase; Metallo-dependent phosphatase; Specificity unclear. (213 aa)
gltDGlutamate synthase (NADPH/NADH) small chain; 1.4.1.14], Glutamate synthase (NADPH), homotetrameric, Nitrogenase component 1 type Oxidoreductase; High confidence in function and specificity. (447 aa)
acsCAcetyl-CoA decarbonylase/synthase complex, gamma subunit, CO dehydrogenase/acetyl-CoA synthase delta subunit; High confidence in function and specificity. (444 aa)
acsDCO dehydrogenase/acetyl-CoA synthase delta subunit; High confidence in function and specificity. (303 aa)
acsBBifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; In acetogenic organisms, this enzyme complex converts carbon dioxide to acetyl-CoA while in methanogenic organisms this enzyme is used to degrade acetyl-CoA to form methane and carbon dioxide; part of an enzyme complex; High confidence in function and specificity. (673 aa)
BN140_2473Acyl-CoA synthetase (NDP forming); CoA binding domain; High confidence in function and specificity. (698 aa)
ldhLactate/malate dehydrogenase, C-terminal; High confidence in function and specificity. (419 aa)
Your Current Organism:
Methanoculleus bourgensis
NCBI taxonomy Id: 1201294
Other names: M. bourgensis MS2, Methanoculleus bourgensis DSM 3045, Methanoculleus bourgensis MS2
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