STRINGSTRING
B005_0387 B005_0387 rpmG rpmG B005_2645 B005_2645 nuoN nuoN B005_2597 B005_2597 topA topA B005_2204 B005_2204 recR recR B005_2027 B005_2027 dnaB dnaB rpsF rpsF B005_1975 B005_1975 B005_1974 B005_1974 rpmH rpmH recF recF gyrB gyrB B005_1936 B005_1936 pknB pknB B005_1893 B005_1893 B005_1869 B005_1869 B005_1858 B005_1858 nth nth B005_1837 B005_1837 B005_1836 B005_1836 B005_1835 B005_1835 B005_1737 B005_1737 B005_1615 B005_1615 dtd dtd B005_1360 B005_1360 B005_1297 B005_1297 B005_1151 B005_1151 B005_1142 B005_1142 B005_1136 B005_1136 B005_1020 B005_1020 B005_0989 B005_0989 B005_0928 B005_0928 raiA raiA B005_0873 B005_0873 hupB hupB rpsO rpsO crtI crtI B005_0655 B005_0655 rpsN rpsN rpmB rpmB rpsR rpsR B005_0557 B005_0557 B005_0525 B005_0525 rplU rplU cgtA cgtA B005_0458 B005_0458 rplJ rplJ B005_0381 B005_0381 B005_0374 B005_0374 cobB-2 cobB-2 B005_0159 B005_0159 B005_0155 B005_0155 B005_0078 B005_0078 B005_0050 B005_0050 B005_0044 B005_0044 rpmI rpmI rplT rplT recN recN B005_5585 B005_5585 B005_5390 B005_5390 B005_5378 B005_5378 B005_5342 B005_5342 B005_5274 B005_5274 B005_5173 B005_5173 B005_5118 B005_5118 B005_5099 B005_5099 B005_5066 B005_5066 B005_4944 B005_4944 ccsB ccsB B005_4750 B005_4750 B005_4708 B005_4708 B005_4663 B005_4663 B005_4661 B005_4661 B005_4557 B005_4557 B005_4555 B005_4555 B005_4503 B005_4503 B005_4336 B005_4336 rpmG-3 rpmG-3 rpmE2-2 rpmE2-2 rpmF-2 rpmF-2 B005_4264 B005_4264 B005_4261 B005_4261 B005_4218 B005_4218 rpmE2 rpmE2 rpmG-2 rpmG-2 B005_4111 B005_4111 B005_4084 B005_4084 B005_4056 B005_4056 B005_4044 B005_4044 B005_4012 B005_4012 B005_3997 B005_3997 aroH aroH B005_3898 B005_3898 B005_3888 B005_3888 B005_3830 B005_3830 B005_3811 B005_3811 priA priA pdxS pdxS kynU kynU B005_3676 B005_3676 B005_3657 B005_3657 dnaG dnaG recO recO rpsT rpsT B005_3538 B005_3538 B005_3463 B005_3463 B005_3429 B005_3429 B005_3272 B005_3272 B005_3214 B005_3214 rpmE rpmE B005_3128 B005_3128 rpsB rpsB rpsP rpsP B005_3066 B005_3066 smc smc rpmF rpmF rpmB-2 rpmB-2 B005_3030 B005_3030 B005_2960 B005_2960 rpsI rpsI rplM rplM rplQ rplQ rpsK rpsK rpmJ rpmJ rplO rplO rpmD rpmD rpsE rpsE rplR rplR rpsH rpsH rpsZ rpsZ rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rpsC rpsC rplB rplB rplW rplW rplC rplC rpsJ rpsJ rpsG rpsG rplL rplL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
B005_0387TPR repeat family protein. (108 aa)
rpmGRibosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
B005_2645Glucose inhibited division A family protein. (382 aa)
nuoNProton-translocating NADH-quinone oxidoreductase, chain N family protein; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (554 aa)
B005_2597Cytochrome C assembly family protein. (427 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (941 aa)
B005_2204Hypothetical protein. (88 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa)
B005_2027DNA-binding protein, YbaB/EbfC family; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (112 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (450 aa)
rpsFRibosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (96 aa)
B005_1975parB/RepB/Spo0J family partition domain protein; Belongs to the ParB family. (327 aa)
B005_1974cobQ/CobB/MinD/ParA nucleotide binding domain protein. (305 aa)
rpmHRibosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (47 aa)
recFDNA replication and repair RecF family protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (376 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (623 aa)
B005_1936Carbohydrate binding domain protein. (599 aa)
pknBSerine/threonine-protein kinase pknB. (602 aa)
B005_1893Hypothetical protein. (204 aa)
B005_1869Hypothetical protein. (356 aa)
B005_1858Putative ser/Thr protein phosphatase. (306 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (218 aa)
B005_1837Type II secretion system (T2SS), F family protein. (233 aa)
B005_1836Type II secretion system (T2SS), F family protein. (221 aa)
B005_1835Type II/IV secretion system family protein. (430 aa)
B005_1737Class II Aldolase and Adducin N-terminal domain protein. (221 aa)
B005_1615Putative acetyltransferase/acyltransferase. (187 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (141 aa)
B005_1360Cupin domain protein. (274 aa)
B005_1297Tetratricopeptide repeat family protein. (543 aa)
B005_1151Ribosomal protein L25, Ctc-form; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (168 aa)
B005_1142Sulfotransferase domain protein. (308 aa)
B005_1136Sulfotransferase domain protein. (291 aa)
B005_1020Hypothetical protein. (183 aa)
B005_0989Bacterial extracellular solute-binding family protein. (343 aa)
B005_0928Tetratricopeptide repeat family protein. (672 aa)
raiARibosomal subunit interface protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (224 aa)
B005_0873Hypothetical protein; Belongs to the SOS response-associated peptidase family. (273 aa)
hupBDNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
rpsORibosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
crtIPhytoene desaturase family protein. (335 aa)
B005_0655ADP-ribosylglycohydrolase family protein. (369 aa)
rpsN30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rpmBRibosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (78 aa)
rpsRRibosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (66 aa)
B005_0557CYTH domain protein. (116 aa)
B005_0525Nuclease-related domain protein. (258 aa)
rplURibosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
cgtAObg family GTPase CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (454 aa)
B005_0458Hypothetical protein. (725 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (175 aa)
B005_0381ATP-dependent DNA helicase, RecQ family protein. (718 aa)
B005_0374CHAT domain protein. (617 aa)
cobB-2Sir2 family protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily. (290 aa)
B005_0159Bacterial regulatory s, luxR family protein. (941 aa)
B005_0155Bacterial regulatory s, luxR family protein. (987 aa)
B005_0078Phosphotransferase enzyme family protein. (654 aa)
B005_0050Hypothetical protein. (410 aa)
B005_0044Sigma-54 interaction domain protein. (454 aa)
rpmIRibosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
rplTRibosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (120 aa)
recNDNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (570 aa)
B005_5585Tat (twin-arginine translocation) pathway signal sequence domain protein. (128 aa)
B005_5390Phosphoribulokinase / Uridine kinase family protein. (180 aa)
B005_5378TPR repeat family protein. (333 aa)
B005_5342Putative transcriptional regulator. (68 aa)
B005_5274AAA ATPase domain protein. (613 aa)
B005_5173ADP-ribosylglycohydrolase domain protein. (155 aa)
B005_5118Saccharopine dehydrogenase. (392 aa)
B005_5099Class II Aldolase and Adducin N-terminal domain protein. (216 aa)
B005_5066Bacterial extracellular solute-binding family protein. (450 aa)
B005_4944TPR repeat family protein. (853 aa)
ccsBCytochrome c-type biogenesis protein CcsB. (304 aa)
B005_4750Methyltransferase domain protein. (217 aa)
B005_4708Hypothetical protein. (280 aa)
B005_4663ADP-ribosylglycohydrolase family protein. (283 aa)
B005_4661Dual specificity phosphatase, catalytic domain protein. (138 aa)
B005_4557SPFH domain / Band 7 family protein. (380 aa)
B005_4555Methyltransferase domain protein. (233 aa)
B005_4503Cupin domain protein. (114 aa)
B005_4336Tetratricopeptide repeat family protein. (637 aa)
rpmG-3Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (54 aa)
rpmE2-2Ribosomal protein L31. (81 aa)
rpmF-2Ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (56 aa)
B005_4264CYTH domain protein. (201 aa)
B005_4261Hypothetical protein. (809 aa)
B005_4218Glucose-binding protein. (419 aa)
rpmE2Ribosomal protein L31. (81 aa)
rpmG-2Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (54 aa)
B005_4111DEAD/DEAH box helicase family protein. (947 aa)
B005_4084TPR repeat family protein. (417 aa)
B005_4056Cyclic nucleotide-binding domain protein. (467 aa)
B005_4044Hypothetical protein. (391 aa)
B005_4012Hypothetical protein. (69 aa)
B005_3997Sir2 family protein. (265 aa)
aroHChorismate mutase. (120 aa)
B005_3898cobQ/CobB/MinD/ParA nucleotide binding domain protein. (319 aa)
B005_3888S1 RNA binding domain protein. (497 aa)
B005_3830ATP-dependent protease La domain protein. (260 aa)
B005_3811Prokaryotic dksA/traR C4-type zinc finger family protein. (136 aa)
priAPutative primosome assembly protein PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (681 aa)
pdxSPyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (303 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (412 aa)
B005_3676DEAD/DEAH box helicase family protein. (834 aa)
B005_3657Hypothetical protein. (179 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (941 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (243 aa)
rpsTRibosomal protein S20; Binds directly to 16S ribosomal RNA. (89 aa)
B005_3538Methyltransferase domain protein. (227 aa)
B005_3463TIR domain protein. (180 aa)
B005_3429Type II/IV secretion system family protein. (441 aa)
B005_3272Binding--dependent transport system inner membrane component family protein; Overlaps another CDS with the same product name. (226 aa)
B005_3214cob(I)yrinic acid a,c-diamide adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (198 aa)
rpmERibosomal protein L31; Binds the 23S rRNA. (69 aa)
B005_3128Alpha/beta hydrolase family protein. (559 aa)
rpsBRibosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (310 aa)
rpsPRibosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (151 aa)
B005_3066Ribosomal L7/L12 C-terminal domain protein. (117 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1182 aa)
rpmFRibosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (58 aa)
rpmB-2Ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (61 aa)
B005_3030Bacterial DNA-binding family protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (93 aa)
B005_2960Zeta toxin family protein. (378 aa)
rpsIRibosomal S9/S16 family protein; Belongs to the universal ribosomal protein uS9 family. (169 aa)
rplMRibosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (126 aa)
rplQRibosomal protein L17. (156 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (134 aa)
rpmJRibosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
rplORibosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (154 aa)
rpmDRibosomal protein L30. (61 aa)
rpsERibosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (200 aa)
rplRRibosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (103 aa)
rpsH30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rpsZ30S ribosomal protein S14 type Z; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa)
rplXRibosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (101 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (90 aa)
rpmCRibosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (84 aa)
rpsCRibosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (263 aa)
rplBRibosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (279 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (96 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (216 aa)
rpsJRibosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rpsGRibosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rplLRibosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (129 aa)
Your Current Organism:
Nocardiopsis alba
NCBI taxonomy Id: 1205910
Other names: N. alba ATCC BAA-2165, Nocardiopsis alba ATCC BAA-2165, Nocardiopsis alba BE74
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