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tyrS tyrS thiI thiI B005_0346 B005_0346 leuS leuS nadD nadD B005_0508 B005_0508 argG argG ribF ribF cysD cysD guaA guaA metG metG B005_1294 B005_1294 argS argS cysS cysS B005_1517 B005_1517 B005_1885 B005_1885 B005_1886 B005_1886 nadE nadE tilS tilS panC panC trmU trmU gltX gltX coaD coaD B005_3122 B005_3122 B005_3123 B005_3123 B005_3174 B005_3174 trpS trpS B005_3649 B005_3649 B005_3666 B005_3666 ileS ileS mshC mshC B005_4247 B005_4247 B005_4250 B005_4250 B005_4899 B005_4899 B005_5294 B005_5294 cysH cysH valS valS
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
tyrStyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (432 aa)
thiItRNA sulfurtransferase ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (429 aa)
B005_0346Universal stress family protein. (307 aa)
leuSleucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (831 aa)
nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (189 aa)
B005_0508Cytidyltransferase-like domain protein. (167 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (481 aa)
ribFRiboflavin biosynthesis protein RibF; Belongs to the ribF family. (320 aa)
cysDSulfate adenylyltransferase, small subunit. (310 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (526 aa)
metGmethionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (605 aa)
B005_1294Universal stress family protein. (300 aa)
argSarginine--tRNA ligase. (581 aa)
cysScysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (466 aa)
B005_1517FAD binding domain of DNA photolyase family protein. (437 aa)
B005_1885Universal stress family protein. (299 aa)
B005_1886Universal stress family protein. (307 aa)
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (276 aa)
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (316 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (292 aa)
trmUtRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (364 aa)
gltXglutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (466 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (157 aa)
B005_3122Electron transfer flavodomain protein. (259 aa)
B005_3123Electron transfer flavodomain protein. (314 aa)
B005_3174Universal stress family protein. (847 aa)
trpStryptophan--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (337 aa)
B005_3649Hypothetical protein. (383 aa)
B005_3666Asparagine synthase family protein. (614 aa)
ileSisoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1066 aa)
mshCcysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (408 aa)
B005_4247Universal stress family protein. (294 aa)
B005_4250Universal stress family protein. (296 aa)
B005_4899Hypothetical protein. (151 aa)
B005_5294Hypothetical protein. (430 aa)
cysHPhosophoadenylyl-sulfate reductase family protein; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (233 aa)
valStRNA synthetases class I (C) catalytic domain protein; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner. (853 aa)
Your Current Organism:
Nocardiopsis alba
NCBI taxonomy Id: 1205910
Other names: N. alba ATCC BAA-2165, Nocardiopsis alba ATCC BAA-2165, Nocardiopsis alba BE74
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