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msrQ msrQ D104_16650 D104_16650 D104_02635 D104_02635 D104_02965 D104_02965 D104_17480 D104_17480 D104_03355 D104_03355 D104_03360 D104_03360 glk glk glmM glmM murA murA D104_04810 D104_04810 D104_04815 D104_04815 D104_04820 D104_04820 D104_04830 D104_04830 D104_04910 D104_04910 D104_05090 D104_05090 D104_05120 D104_05120 D104_05665 D104_05665 cpsB cpsB D104_05675 D104_05675 D104_05755 D104_05755 D104_05760 D104_05760 D104_05765 D104_05765 D104_17175 D104_17175 D104_05770 D104_05770 fcl fcl gmd gmd D104_06075 D104_06075 D104_07280 D104_07280 glmS glmS glmU glmU D104_07925 D104_07925 D104_08415 D104_08415 D104_17530 D104_17530 D104_08810 D104_08810 murB murB D104_09325 D104_09325 D104_10060 D104_10060 D104_13540 D104_13540 D104_13940 D104_13940 pgi pgi D104_14605 D104_14605 D104_14610 D104_14610 nagB nagB glgC glgC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
msrQMembrane protein; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the qui [...] (208 aa)
D104_16650Peroxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (207 aa)
D104_02635Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
D104_02965Preprotein translocase subunit SecB; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa)
D104_17480Phosphoglucomutase; Catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (547 aa)
D104_03355N-acylglucosamine 2-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
D104_03360ROK family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
glkGlucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial glucokinase family. (324 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (448 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (420 aa)
D104_04810N-acetylneuraminate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
D104_04815Spore coat protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
D104_04820CMP-N-acetylneuraminic acid synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
D104_04830N-acetyl glucosamine/N-acetyl galactosamine epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
D104_04910UTP--glucose-1-phosphate uridylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
D104_05090UDP-glucose 6-dehydrogenase; Catalyzes the formation of UDP-glucuronate from UDP-glucose; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
D104_05120Phosphomannose isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
D104_05665Phosphomannomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (492 aa)
cpsBMannose-1-phosphate guanyltransferase; Capsular polysaccharide colanic acid biosynthesis protein; catalyzes the formation of GDP-mannose from GTP and alpha-D-mannose 1-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the mannose-6-phosphate isomerase type 2 family. (465 aa)
D104_05675UDP-glucose 4-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (337 aa)
D104_05755Lipopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DegT/DnrJ/EryC1 family. (438 aa)
D104_05760CDP-glucose 4,6-dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
D104_05765Glucose-1-phosphate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
D104_17175TopA protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
D104_05770Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
fclGDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (321 aa)
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (375 aa)
D104_06075ADP-binding protein; Needed for nucleoid integrity; possibly involved in cell wall synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (156 aa)
D104_07280Fructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
glmSGlucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (608 aa)
glmUGlucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (453 aa)
D104_07925Cupin; Derived by automated computational analysis using gene prediction method: Protein Homology. (103 aa)
D104_08415RpiR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
D104_17530Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (643 aa)
D104_08810Alkyl hydroperoxide reductase subunit C; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (185 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (364 aa)
D104_09325Maltose O-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
D104_10060Naphthalene 1,2-dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
D104_13540Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
D104_13940Iron-sulfur cluster assembly protein HesB; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (548 aa)
D104_14605N-acetylglucosamine 6-phosphate deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
D104_14610N-acetylglucosamine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
nagBGlucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (266 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (417 aa)
Your Current Organism:
Marinomonas profundimaris
NCBI taxonomy Id: 1208321
Other names: LMG 27696, LMG:27696, M. profundimaris, MCCC 1A07573, Marinomonas profundimaris Bai et al. 2015, Marinomonas sp. D104, strain 25BN12M-4, strain D104
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