STRINGSTRING
sucC sucC sucD sucD CDSE_0547 CDSE_0547 CDSE_0548 CDSE_0548 CDSE_0549 CDSE_0549 CDSE_0710 CDSE_0710 CDSE_0712 CDSE_0712 CDSE_0714 CDSE_0714
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sucCsuccinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
sucDsuccinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
CDSE_0547Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (903 aa)
CDSE_0548Pyruvate dehydrogenase E2 component; Energy production and conversion; SecretomeP prediction: 0.21; Protein involved in lipoic acid binding. (449 aa)
CDSE_0549Dihydrolipoamide dehydrogenase; Energy production and conversion; SecretomeP prediction: 0.05; Protein involved in oxidation-reduction process. (567 aa)
CDSE_0710Dihydrolipoamide dehydrogenase; Energy production and conversion; SecretomeP prediction: 0.38; Protein involved in oxidation-reduction process. (474 aa)
CDSE_07122-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (399 aa)
CDSE_07142-oxoglutarate dehydrogenase E1 component; Energy production and conversion; SecretomeP prediction: 0.15; Protein involved in oxidation-reduction process. (957 aa)
Your Current Organism:
Kinetoplastibacterium desouzaii
NCBI taxonomy Id: 1208919
Other names: C. Kinetoplastibacterium desouzaii TCC079E, Candidatus Kinetoplastibacterium desouzaii TCC079E
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.