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glyA glyA gltX gltX CDSE_0044 CDSE_0044 CDSE_0045 CDSE_0045 hemL hemL gpmA gpmA CDSE_0098 CDSE_0098 dapF dapF lysA lysA CDSE_0152 CDSE_0152 CDSE_0211 CDSE_0211 CDSE_0255 CDSE_0255 hemA hemA ppc ppc CDSE_0307 CDSE_0307 prs prs CDSE_0346 CDSE_0346 CDSE_0347 CDSE_0347 pgk pgk CDSE_0351 CDSE_0351 tal tal dapA dapA accA accA CDSE_0397 CDSE_0397 rpiA rpiA sucC sucC sucD sucD hemC hemC CDSE_0447 CDSE_0447 CDSE_0448 CDSE_0448 asd asd dapE dapE dapD dapD CDSE_0480 CDSE_0480 folD folD CDSE_0547 CDSE_0547 CDSE_0548 CDSE_0548 CDSE_0549 CDSE_0549 CDSE_0585 CDSE_0585 CDSE_0605 CDSE_0605 fbp fbp CDSE_0625 CDSE_0625 serC serC CDSE_0710 CDSE_0710 CDSE_0712 CDSE_0712 CDSE_0714 CDSE_0714 CDSE_0715 CDSE_0715 eno eno CDSE_0722 CDSE_0722 accD accD tpiA tpiA dapB dapB pdxH pdxH
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (466 aa)
CDSE_0044acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
CDSE_0045acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (142 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase; Coenzyme metabolism; SecretomeP prediction: 0.18; Protein involved in glutamate-1-semialdehyde 2,1-aminomutase activity. (425 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (247 aa)
CDSE_0098L-lactate dehydrogenase; Energy production and conversion; SecretomeP prediction: 0.59; Protein involved in oxidation-reduction process; Belongs to the LDH2/MDH2 oxidoreductase family. (349 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (298 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (418 aa)
CDSE_0152Porphobilinogen synthase AlaD; Coenzyme metabolism; SecretomeP prediction: 0.05; Protein involved in metal ion binding; Belongs to the ALAD family. (340 aa)
CDSE_0211acetylornithine/N-succinyldiaminopimelate aminotransferase; Amino acid transport and metabolism; SecretomeP prediction: 0.16; Protein involved in pyridoxal phosphate binding; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (396 aa)
CDSE_0255Ribulose-phosphate 3-epimerase; Carbohydrate transport and metabolism; SecretomeP prediction: 0.04; Protein involved in isomerase activity; Belongs to the ribulose-phosphate 3-epimerase family. (234 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (418 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (941 aa)
CDSE_0307Phosphomannomutase; Carbohydrate transport and metabolism; SecretomeP prediction: 0.1; Protein involved in intramolecular transferase activity, phosphotransferases. (444 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (309 aa)
CDSE_0346Transketolase; Carbohydrate transport and metabolism; SecretomeP prediction: 0.14; Protein involved in transferase activity; Belongs to the transketolase family. (680 aa)
CDSE_0347Glyceraldehyde 3-phosphate dehydrogenase; Carbohydrate transport and metabolism; SecretomeP prediction: 0.17; Protein involved in oxidation-reduction process; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
pgkPhosphoglycerate kinase; Carbohydrate transport and metabolism; SecretomeP prediction: 0.07; Protein involved in transferase activity; Belongs to the phosphoglycerate kinase family. (398 aa)
CDSE_0351Class II fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (350 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (316 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa)
accAacetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (320 aa)
CDSE_0397Aspartate kinase; Amino acid transport and metabolism; SecretomeP prediction: 0.08; Protein involved in transferase activity; Belongs to the aspartokinase family. (424 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (223 aa)
sucCsuccinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
sucDsuccinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
hemCHydroxymethylbilane synthase hemC; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (308 aa)
CDSE_0447uroporphyrinogen-III synthase hemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (264 aa)
CDSE_0448uroporphyrin-III C-methyltransferase; Coenzyme metabolism; SecretomeP prediction: 0.16. (318 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (375 aa)
dapESuccinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (379 aa)
dapD2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Amino acid transport and metabolism; SecretomeP prediction: 0.38; Protein involved in diaminopimelate biosynthetic process; Belongs to the transferase hexapeptide repeat family. (273 aa)
CDSE_0480acetylornithine/N-succinyldiaminopimelate aminotransferase; Amino acid transport and metabolism; SecretomeP prediction: 0.78; Protein involved in pyridoxal phosphate binding. (399 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
CDSE_0547Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (903 aa)
CDSE_0548Pyruvate dehydrogenase E2 component; Energy production and conversion; SecretomeP prediction: 0.21; Protein involved in lipoic acid binding. (449 aa)
CDSE_0549Dihydrolipoamide dehydrogenase; Energy production and conversion; SecretomeP prediction: 0.05; Protein involved in oxidation-reduction process. (567 aa)
CDSE_0585Pyruvate, water dikinase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (787 aa)
CDSE_0605Zn-dependent 6-hydroxyhexanoate dehydrogenase; General function prediction only; SecretomeP prediction: 0.05; Protein involved in oxidation-reduction process. (354 aa)
fbpCarbohydrate transport and metabolism; SecretomeP prediction: 0.04; Protein involved in phosphoric ester hydrolase activity; Belongs to the FBPase class 1 family. (335 aa)
CDSE_0625Homoserine dehydrogenase; Amino acid transport and metabolism; SecretomeP prediction: 0.13; Protein involved in oxidation-reduction process. (436 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (375 aa)
CDSE_0710Dihydrolipoamide dehydrogenase; Energy production and conversion; SecretomeP prediction: 0.38; Protein involved in oxidation-reduction process. (474 aa)
CDSE_07122-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (399 aa)
CDSE_07142-oxoglutarate dehydrogenase E1 component; Energy production and conversion; SecretomeP prediction: 0.15; Protein involved in oxidation-reduction process. (957 aa)
CDSE_0715Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+); Energy production and conversion; SecretomeP prediction: 0.11; Protein involved in oxidation-reduction process. (761 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
CDSE_0722acetyl-CoA synthetase; Lipid metabolism; SecretomeP prediction: 0.09; Protein involved in ligase activity. (660 aa)
accDacetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (286 aa)
tpiATriosephosphate isomerase TIM; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (267 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (213 aa)
Your Current Organism:
Kinetoplastibacterium desouzaii
NCBI taxonomy Id: 1208919
Other names: C. Kinetoplastibacterium desouzaii TCC079E, Candidatus Kinetoplastibacterium desouzaii TCC079E
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