STRINGSTRING
glyA glyA CDSE_0044 CDSE_0044 CDSE_0045 CDSE_0045 gpmA gpmA ilvA ilvA CDSE_0255 CDSE_0255 ppc ppc prs prs CDSE_0346 CDSE_0346 CDSE_0347 CDSE_0347 pgk pgk CDSE_0351 CDSE_0351 tal tal accA accA rpiA rpiA sucC sucC sucD sucD folD folD CDSE_0547 CDSE_0547 CDSE_0548 CDSE_0548 CDSE_0549 CDSE_0549 CDSE_0585 CDSE_0585 fbp fbp serC serC CDSE_0710 CDSE_0710 CDSE_0712 CDSE_0712 CDSE_0714 CDSE_0714 CDSE_0715 CDSE_0715 eno eno CDSE_0722 CDSE_0722 accD accD tpiA tpiA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
CDSE_0044acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
CDSE_0045acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (142 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (247 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (502 aa)
CDSE_0255Ribulose-phosphate 3-epimerase; Carbohydrate transport and metabolism; SecretomeP prediction: 0.04; Protein involved in isomerase activity; Belongs to the ribulose-phosphate 3-epimerase family. (234 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (941 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (309 aa)
CDSE_0346Transketolase; Carbohydrate transport and metabolism; SecretomeP prediction: 0.14; Protein involved in transferase activity; Belongs to the transketolase family. (680 aa)
CDSE_0347Glyceraldehyde 3-phosphate dehydrogenase; Carbohydrate transport and metabolism; SecretomeP prediction: 0.17; Protein involved in oxidation-reduction process; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
pgkPhosphoglycerate kinase; Carbohydrate transport and metabolism; SecretomeP prediction: 0.07; Protein involved in transferase activity; Belongs to the phosphoglycerate kinase family. (398 aa)
CDSE_0351Class II fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (350 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (316 aa)
accAacetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (320 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (223 aa)
sucCsuccinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
sucDsuccinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
CDSE_0547Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (903 aa)
CDSE_0548Pyruvate dehydrogenase E2 component; Energy production and conversion; SecretomeP prediction: 0.21; Protein involved in lipoic acid binding. (449 aa)
CDSE_0549Dihydrolipoamide dehydrogenase; Energy production and conversion; SecretomeP prediction: 0.05; Protein involved in oxidation-reduction process. (567 aa)
CDSE_0585Pyruvate, water dikinase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (787 aa)
fbpCarbohydrate transport and metabolism; SecretomeP prediction: 0.04; Protein involved in phosphoric ester hydrolase activity; Belongs to the FBPase class 1 family. (335 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (375 aa)
CDSE_0710Dihydrolipoamide dehydrogenase; Energy production and conversion; SecretomeP prediction: 0.38; Protein involved in oxidation-reduction process. (474 aa)
CDSE_07122-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (399 aa)
CDSE_07142-oxoglutarate dehydrogenase E1 component; Energy production and conversion; SecretomeP prediction: 0.15; Protein involved in oxidation-reduction process. (957 aa)
CDSE_0715Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+); Energy production and conversion; SecretomeP prediction: 0.11; Protein involved in oxidation-reduction process. (761 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
CDSE_0722acetyl-CoA synthetase; Lipid metabolism; SecretomeP prediction: 0.09; Protein involved in ligase activity. (660 aa)
accDacetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (286 aa)
tpiATriosephosphate isomerase TIM; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa)
Your Current Organism:
Kinetoplastibacterium desouzaii
NCBI taxonomy Id: 1208919
Other names: C. Kinetoplastibacterium desouzaii TCC079E, Candidatus Kinetoplastibacterium desouzaii TCC079E
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