STRINGSTRING
trpB trpB AEE90360.1 AEE90360.1 hisZ hisZ hisG hisG hisC hisC hisB hisB hisA hisA hisF hisF hisI hisI hisD hisD AEE91476.1 AEE91476.1 trpA trpA trpB-2 trpB-2 trpF trpF trpC trpC trpD trpD trpG trpG trpE trpE aroE aroE AEE92167.1 AEE92167.1 tnaA tnaA pheA pheA aroF aroF AEE92571.1 AEE92571.1 aroB aroB aroA aroA aroC aroC AEE92575.1 AEE92575.1 aroE-2 aroE-2 aroK aroK aroQ aroQ
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (449 aa)
AEE90360.1TIGRFAM: HAD-superfamily hydrolase, subfamily IB, PSPase-like, bacterial; HAD-superfamily hydrolase, subfamily IB, PSPase-like; KEGG: amt:Amet_1228 HAD family hydrolase. (243 aa)
hisZATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (371 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (206 aa)
hisCPFAM: Aminotransferase, class I/classII; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: toc:Toce_1416 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (373 aa)
hisBHAMAP: Imidazoleglycerol-phosphate dehydratase; KEGG: ttm:Tthe_0562 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. (194 aa)
hisA1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ppy:PPE_00178 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (243 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa)
hisIPFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphohydrolase; Histidine biosynthesis bifunctional protein HisIE; KEGG: slp:Slip_0617 phosphoribosyl-ATP diphosphatase; In the N-terminal section; belongs to the PRA-CH family. (211 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (421 aa)
AEE91476.1Aspartate transaminase; KEGG: toc:Toce_1173 aminotransferase class I and II; PFAM: Aminotransferase, class I/classII. (400 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa)
trpB-2Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa)
trpFKEGG: cce:Ccel_3217 N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (202 aa)
trpCKEGG: bpb:bpr_I0011 indole-3-glycerol phosphate synthase TrpC; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (260 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (335 aa)
trpGTIGRFAM: Anthranilate synthase, glutamine amidotransferase domain; KEGG: ere:EUBREC_2979 anthranilate/para-aminobenzoate synthase component II, TrpG; PFAM: Glutamine amidotransferase class-I, C-terminal. (194 aa)
trpEAnthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (492 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (290 aa)
AEE92167.1Histidinol-phosphate transaminase; KEGG: tsi:TSIB_1557 hypothetical protein; PFAM: Aminotransferase, class I/classII. (377 aa)
tnaAHAMAP: Tryptophanase; KEGG: cno:NT01CX_2071 tryptophanase; PFAM: Aromatic amino acid beta-eliminating lyase/threonine aldolase. (460 aa)
pheAKEGG: tpd:Teth39_0983 prephenate dehydratase; PFAM: Prephenate dehydratase; Amino acid-binding ACT. (279 aa)
aroFTIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; KEGG: cbk:CLL_A3144 3-deoxy-7-phosphoheptulonate synthase; PFAM: DAHP synthetase I/KDSA. (337 aa)
AEE92571.1KEGG: cno:NT01CX_0626 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase. (294 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (355 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (434 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (369 aa)
AEE92575.1TIGRFAM: Chorismate mutase, Gram-positive; PFAM: Chorismate mutase, type II; KEGG: clj:CLJU_c29130 bifunctional chorismate mutase/prephenate dehydratase; SMART: Chorismate mutase. (92 aa)
aroE-2Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (143 aa)
Your Current Organism:
Tepidanaerobacter acetatoxydans
NCBI taxonomy Id: 1209989
Other names: T. acetatoxydans Re1, Tepidanaerobacter acetatoxydans Re1, Tepidanaerobacter acetatoxydans str. Re1, Tepidanaerobacter acetatoxydans strain Re1, Tepidanaerobacter sp. Re1
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