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| | AEE92706.1 | KEGG: toc:Toce_2001 cobalamin synthesis protein P47K. (436 aa) |
| | pyrAB | SMART: Methylglyoxal synthase-like domain; TIGRFAM: Carbamoyl-phosphate synthase, large subunit; KEGG: tjr:TherJR_1830 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthase, large subunit, N-terminal; Carbamoyl-phosphate synthetase, large subunit, oligomerisation; Methylglyoxal synthase-like domain; Belongs to the CarB family. (1063 aa) |
| | pheA | KEGG: tpd:Teth39_0983 prephenate dehydratase; PFAM: Prephenate dehydratase; Amino acid-binding ACT. (279 aa) |
| | aroF | TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; KEGG: cbk:CLL_A3144 3-deoxy-7-phosphoheptulonate synthase; PFAM: DAHP synthetase I/KDSA. (337 aa) |
| | AEE92571.1 | KEGG: cno:NT01CX_0626 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase. (294 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (355 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (434 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (369 aa) |
| | AEE92575.1 | TIGRFAM: Chorismate mutase, Gram-positive; PFAM: Chorismate mutase, type II; KEGG: clj:CLJU_c29130 bifunctional chorismate mutase/prephenate dehydratase; SMART: Chorismate mutase. (92 aa) |
| | aroE-2 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (143 aa) |
| | ilvD-2 | PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: clj:CLJU_c20410 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (552 aa) |
| | ilvH-2 | KEGG: mbu:Mbur_0709 acetolactate synthase 3 regulatory subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (178 aa) |
| | AEE92644.1 | HAMAP: Dihydrodipicolinate synthase; KEGG: aco:Amico_1768 dihydrodipicolinate synthetase; PFAM: Dihydrodipicolinate synthetase; Belongs to the DapA family. (304 aa) |
| | AEE92691.1 | PFAM: Domain of unknown function DUF39; KEGG: elm:ELI_3644 protein of unknown function DUF39. (393 aa) |
| | AEE92693.1 | PFAM: Vitamin B12-dependent methionine synthase, activation domain; KEGG: cbe:Cbei_1401 vitamin B12 dependent methionine synthase, activation region. (223 aa) |
| | AEE92694.1 | Methionine synthase; KEGG: str:Sterm_3081 homocysteine S-methyltransferase; PFAM: Homocysteine S-methyltransferase; Pterin-binding; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding. (793 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | proI | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (283 aa) |
| | AEE90272.1 | Amidohydrolase; TIGRFAM: Peptidase M20D, amidohydrolase; KEGG: ctc:CTC02397 N-acyl-L-amino acid amidohydrolase; PFAM: Peptidase M20; Peptidase M20, dimerisation. (395 aa) |
| | abgA | Amidohydrolase; TIGRFAM: Peptidase M20D, amidohydrolase; KEGG: sth:STH1690 putative amino acid amidohydrolase; PFAM: Peptidase M20; Peptidase M20, dimerisation. (429 aa) |
| | AEE90286.1 | PFAM: Radical SAM; KEGG: toc:Toce_0030 radical SAM domain protein. (198 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (449 aa) |
| | AEE90360.1 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB, PSPase-like, bacterial; HAD-superfamily hydrolase, subfamily IB, PSPase-like; KEGG: amt:Amet_1228 HAD family hydrolase. (243 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (363 aa) |
| | leuA | TIGRFAM: Homocitrate synthase NifV-type; KEGG: tit:Thit_0443 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (383 aa) |
| | IDH | KEGG: cac:CA_C0972 isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. (333 aa) |
| | AEE90371.1 | KEGG: toc:Toce_1803 L-threonine ammonia-lyase; TIGRFAM: Threonine dehydratase II; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Amino acid-binding ACT. (402 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (321 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | AEE90483.1 | PFAM: Dihydrodipicolinate reductase, N-terminal; KEGG: ssm:Spirs_3711 dihydrodipicolinate reductase. (346 aa) |
| | AEE90502.1 | PFAM: Ferredoxin; KEGG: toc:Toce_0795 ferredoxin. (609 aa) |
| | acsE | Dihydropteroate synthase DHPS; PFAM: Pterin-binding; KEGG: tjr:TherJR_2629 dihydropteroate synthase DhpS. (268 aa) |
| | folD | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa) |
| | sudA | TIGRFAM: Glutamate synthase (NADPH), homotetrameric; KEGG: tpd:Teth39_0216 glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (464 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (380 aa) |
| | mtnA | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (348 aa) |
| | leuC | KEGG: nth:Nther_2159 3-isopropylmalate dehydratase; TIGRFAM: Homoaconitase/3-isopropylmalate dehydratase, large subunit, prokaryotic; Homoaconitase/3-isopropylmalate dehydratase, large subunit, subgroup; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Belongs to the aconitase/IPM isomerase family. (405 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (178 aa) |
| | selD | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (341 aa) |
| | AEE90634.1 | Phosphoglycerate dehydrogenase; KEGG: elm:ELI_0529 hypothetical protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (343 aa) |
| | acpS | Holo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (140 aa) |
| | alr-2 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (393 aa) |
| | AEE90741.1 | Bifunctional protein folD; HAMAP: Tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: toc:Toce_0805 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); methenyltetrahydrofolate cyclohydrolase; PFAM: Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain. (284 aa) |
| | AEE90748.1 | Dihydropteroate synthase DHPS; PFAM: Pterin-binding; KEGG: toc:Toce_0812 dihydropteroate synthase DhpS. (261 aa) |
| | AEE90751.1 | PFAM: Ferredoxin; KEGG: toc:Toce_0815 ferredoxin. (642 aa) |
| | AEE90840.1 | KEGG: ssm:Spirs_3463 creatinine amidohydrolase, putative. (373 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (371 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (206 aa) |
| | hisC | PFAM: Aminotransferase, class I/classII; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: toc:Toce_1416 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (373 aa) |
| | hisB | HAMAP: Imidazoleglycerol-phosphate dehydratase; KEGG: ttm:Tthe_0562 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ppy:PPE_00178 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (243 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | hisI | PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphohydrolase; Histidine biosynthesis bifunctional protein HisIE; KEGG: slp:Slip_0617 phosphoribosyl-ATP diphosphatase; In the N-terminal section; belongs to the PRA-CH family. (211 aa) |
| | AEE90918.1 | C_GCAxxG_C_C family protein; KEGG: cpr:CPR_2280 hypothetical protein; TIGRFAM: CGCAxxGCC motif; PFAM: CGCAxxGCC motif. (135 aa) |
| | cysK | TIGRFAM: Cysteine synthase A; Cysteine synthase K/M; KEGG: toc:Toce_0731 cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (312 aa) |
| | AEE90956.1 | KEGG: gym:GYMC10_2835 hypothetical protein. (264 aa) |
| | AEE91028.1 | KEGG: toc:Toce_0567 hypothetical protein. (156 aa) |
| | AEE91039.1 | KEGG: toc:Toce_1555 histidinol phosphate phosphatase HisJ family; TIGRFAM: Histidinol phosphate phosphatase, HisJ; PFAM: PHP, C-terminal; Belongs to the PHP hydrolase family. HisK subfamily. (275 aa) |
| | rocD | Acetylornithine/succinyldiaminopimelate aminotransferase; Catalyzes the interconversion of ornithine to glutamate semialdehyde. (396 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (421 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (251 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (328 aa) |
| | fabHA | 3-oxoacyl-(acyl-carrier-protein) synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (326 aa) |
| | fabD | SMART: Polyketide synthase, acyl transferase domain; TIGRFAM: Malonyl CoA-acyl carrier protein transacylase; KEGG: toc:Toce_1056 (acyl-carrier-protein) S-malonyltransferase; PFAM: Acyl transferase. (311 aa) |
| | acpA | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa) |
| | fabF | 3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa) |
| | AEE91424.1 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (401 aa) |
| | yqjD | KEGG: toc:Toce_1831 propionyl-CoA carboxylase carboxyltransferase subunit; PFAM: Carboxyl transferase. (517 aa) |
| | AEE91496.1 | PFAM: GCN5-related N-acetyltransferase (GNAT) domain; Mitochondrial protein Pet127; KEGG: sul:SYO3AOP1_0115 GCN5-related N-acetyltransferase. (154 aa) |
| | AEE91498.1 | PFAM: NADP oxidoreductase, coenzyme F420-dependent; KEGG: gur:Gura_2528 hypothetical protein. (223 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (444 aa) |
| | argR | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (148 aa) |
| | serA | TIGRFAM: D-3-phosphoglycerate dehydrogenase; KEGG: dau:Daud_0012 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Amino acid-binding ACT. (523 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (296 aa) |
| | thrC | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (353 aa) |
| | hom | PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; KEGG: tmt:Tmath_2179 homoserine dehydrogenase. (423 aa) |
| | AEE91731.1 | KEGG: dat:HRM2_29090 hypothetical protein. (242 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa) |
| | trpB-2 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpF | KEGG: cce:Ccel_3217 N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (202 aa) |
| | trpC | KEGG: bpb:bpr_I0011 indole-3-glycerol phosphate synthase TrpC; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (260 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (335 aa) |
| | trpE | Anthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (492 aa) |
| | tarA | Glycosyl transferase, WecB/TagA/CpsF family; Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid. (253 aa) |
| | AEE91863.1 | LmbE family protein; PFAM: N-acetylglucosaminyl phosphatidylinositol deacetylase; KEGG: ttr:Tter_2570 LmbE family protein. (226 aa) |
| | AEE91886.1 | Phosphoglycerate dehydrogenase; KEGG: tmt:Tmath_0226 glyoxylate reductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (310 aa) |
| | AEE91902.1 | Phosphopantetheine-protein transferase; KEGG: csc:Csac_1038 holo-acyl-carrier-protein synthase; TIGRFAM: Phosphopantethiene-protein transferase; PFAM: 4'-phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. (128 aa) |
| | AEE91905.1 | KEGG: bpr:GBP346_A4064 3-oxoacyl-[acyl-carrier-protein (ACP)] synthase III; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III. (352 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase 3; HAMAP: Beta-ketoacyl-acyl carrier protein synthase III (FabH); KEGG: swd:Swoo_1669 beta-ketoacyl-acyl-carrier-protein synthase I; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III. (340 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (303 aa) |
| | AEE91938.1 | KEGG: chd:Calhy_2201 dihydrodipicolinate synthetase; PFAM: Dihydrodipicolinate synthetase; Belongs to the DapA family. (292 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (290 aa) |
| | AEE91989.1 | PFAM: Peptidase M20; Peptidase M20, dimerisation; KEGG: clj:CLJU_c29950 putative deacetylase. (393 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa) |
| | ilvB | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: tjr:TherJR_0360 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (560 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (167 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (424 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (511 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa) |
| | ilvH | KEGG: ate:Athe_0503 acetolactate synthase small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (167 aa) |
| | ilvB-2 | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: drm:Dred_0284 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (557 aa) |
| | AEE92077.1 | Amidohydrolase; TIGRFAM: Peptidase M20D, amidohydrolase; KEGG: cbt:CLH_1367 thermostable carboxypeptidase 1; PFAM: Peptidase M20; Peptidase M20, dimerisation. (391 aa) |
| | ilvD | PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: swo:Swol_2147 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (554 aa) |
| | AEE92089.1 | KEGG: gym:GYMC10_2999 Asp/Glu/hydantoin racemase. (222 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (337 aa) |
| | AEE92111.1 | KEGG: tjr:TherJR_0357 aspartate kinase, monofunctional class; TIGRFAM: Aspartate kinase domain; PFAM: Aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (394 aa) |
| | asd-2 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (337 aa) |
| | AEE92142.1 | PFAM: Creatininase; KEGG: bha:BH0226 creatinine amidohydrolase. (239 aa) |
| | AEE92167.1 | Histidinol-phosphate transaminase; KEGG: tsi:TSIB_1557 hypothetical protein; PFAM: Aminotransferase, class I/classII. (377 aa) |
| | fabZ | (3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (142 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (414 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (272 aa) |
| | AEE92268.1 | Phosphoglycerate dehydrogenase; KEGG: ate:Athe_1994 D-isomer specific 2-hydroxyacid dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (365 aa) |
| | cysE | KEGG: toc:Toce_2115 serine O-acetyltransferase; TIGRFAM: Serine O-acetyltransferase. (224 aa) |
| | AEE92332.1 | KEGG: nml:Namu_0013 ribulose-bisphosphate carboxylase; PFAM: Ribulose bisphosphate carboxylase, large subunit, C-terminal; Belongs to the RuBisCO large chain family. (427 aa) |
| | AEE92376.1 | TIGRFAM: Dihydropteroate synthase; KEGG: dth:DICTH_0461 dihydropteroate synthase; PFAM: Pterin-binding. (396 aa) |
| | AEE92377.1 | TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: dtu:Dtur_0617 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (155 aa) |
| | citD | Citrate lyase acyl carrier protein; Covalent carrier of the coenzyme of citrate lyase. (97 aa) |
| | AEE92397.1 | KEGG: efe:EFER_3668 putative isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. (389 aa) |
| | leuD-3 | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (173 aa) |
| | leuC-3 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (423 aa) |
| | AEE92466.1 | PFAM: Acyl-ACP thioesterase; KEGG: chy:CHY_0816 acyl carrier protein thioesterase-like protein. (249 aa) |
| | AEE92547.1 | KEGG: ckr:CKR_2362 hypothetical protein. (93 aa) |
| | AEE92548.1 | KEGG: cth:Cthe_1741 hypothetical protein. (83 aa) |
