Your Input: | |
| | nagB | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (244 aa) |
| | cobB | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (457 aa) |
| | AEE90645.1 | UPF0597 protein yhaM; HAMAP: Uncharacterised protein family UPF0597; KEGG: bpo:BP951000_1867 hypothetical protein; Belongs to the UPF0597 family. (426 aa) |
| | cysA | KEGG: toc:Toce_1559 methionine gamma-lyase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme. (396 aa) |
| | AEE90636.1 | L-iditol 2-dehydrogenase; KEGG: brh:RBRH_01139 (R,R)-butanediol dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, C-terminal. (352 aa) |
| | AEE90634.1 | Phosphoglycerate dehydrogenase; KEGG: elm:ELI_0529 hypothetical protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (343 aa) |
| | AEE90629.1 | TIGRFAM: Cysteine desulfurase-related, unknown function; KEGG: csh:Closa_1018 cysteine desulfurase family protein; PFAM: Aminotransferase, class V/Cysteine desulfurase. (380 aa) |
| | selD | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (341 aa) |
| | AEE90621.1 | TIGRFAM: Selenium-dependent molybdenum hydroxylase system protein, YqeB family; KEGG: mta:Moth_2002 biotin/lipoyl attachment. (267 aa) |
| | Hnr | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; PFAM: 4Fe-4S binding domain; KEGG: ipo:Ilyop_0118 6-hydroxynicotinate reductase. (504 aa) |
| | Ena-2 | PFAM: Amidohydrolase 1; KEGG: ipo:Ilyop_0117 enamidase. (386 aa) |
| | ndhM | Xanthine dehydrogenase; KEGG: nth:Nther_2150 aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; PFAM: Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding. (328 aa) |
| | AEE90612.1 | Carbon-monoxide dehydrogenase (acceptor); KEGG: nth:Nther_2153 molybdopterin dehydrogenase FAD-binding; PFAM: Molybdopterin dehydrogenase, FAD-binding; CO dehydrogenase flavoprotein, C-terminal. (290 aa) |
| | Ena | PFAM: Amidohydrolase 1; KEGG: ipo:Ilyop_0117 enamidase. (386 aa) |
| | Dml | KEGG: nth:Nther_2154 carboxyvinyl-carboxyphosphonate phosphorylmutase; PFAM: Isocitrate lyase/phosphorylmutase. (290 aa) |
| | mii | PFAM: PrpF protein; KEGG: nth:Nther_2156 protein of unknown function DUF453. (384 aa) |
| | mgm | KEGG: nth:Nther_2157 2-methyleneglutarate mutase; PFAM: Cobalamin (vitamin B12)-binding. (615 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (178 aa) |
| | leuC | KEGG: nth:Nther_2159 3-isopropylmalate dehydratase; TIGRFAM: Homoaconitase/3-isopropylmalate dehydratase, large subunit, prokaryotic; Homoaconitase/3-isopropylmalate dehydratase, large subunit, subgroup; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Belongs to the aconitase/IPM isomerase family. (405 aa) |
| | mtnA | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (348 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (380 aa) |
| | AEE90577.1 | KEGG: toc:Toce_0246 CoA-substrate-specific enzyme activase; TIGRFAM: CoA enzyme activase; PFAM: ATPase, BadF/BadG/BcrA/BcrD type. (320 aa) |
| | sudA | TIGRFAM: Glutamate synthase (NADPH), homotetrameric; KEGG: tpd:Teth39_0216 glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (464 aa) |
| | AEE90557.1 | Ureidoglycolate lyase; KEGG: tpd:Teth39_1973 5-carboxymethyl-2-hydroxymuconate delta-isomerase; PFAM: Fumarylacetoacetase, C-terminal-like; Domain of unknown function DUF2437. (251 aa) |
| | gcvPB | Glycine dehydrogenase (decarboxylating) subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (482 aa) |
| | gcvPA | Glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (443 aa) |
| | gcvH-2 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (354 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (124 aa) |
| | AEE90510.1 | PFAM: Methylenetetrahydrofolate reductase; KEGG: clj:CLJU_c37610 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (291 aa) |
| | folD | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa) |
| | acsE | Dihydropteroate synthase DHPS; PFAM: Pterin-binding; KEGG: tjr:TherJR_2629 dihydropteroate synthase DhpS. (268 aa) |
| | AEE90502.1 | PFAM: Ferredoxin; KEGG: toc:Toce_0795 ferredoxin. (609 aa) |
| | AEE90483.1 | PFAM: Dihydrodipicolinate reductase, N-terminal; KEGG: ssm:Spirs_3711 dihydrodipicolinate reductase. (346 aa) |
| | AEE90474.1 | L-threonine 3-dehydrogenase; KEGG: tde:TDE0075 sorbitol dehydrogenase, putative; PFAM: Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, C-terminal. (349 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | lysS | PFAM: Aminoacyl-tRNA synthetase, class II (D/K/N); Nucleic acid binding, OB-fold, tRNA/helicase-type; TIGRFAM: Lysyl-tRNA synthetase, class II; HAMAP: Lysyl-tRNA synthetase, class II; KEGG: toc:Toce_0164 lysyl-tRNA synthetase. (493 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (321 aa) |
| | AEE90371.1 | KEGG: toc:Toce_1803 L-threonine ammonia-lyase; TIGRFAM: Threonine dehydratase II; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Amino acid-binding ACT. (402 aa) |
| | IDH | KEGG: cac:CA_C0972 isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. (333 aa) |
| | leuA | TIGRFAM: Homocitrate synthase NifV-type; KEGG: tit:Thit_0443 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (383 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (363 aa) |
| | AEE90360.1 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB, PSPase-like, bacterial; HAD-superfamily hydrolase, subfamily IB, PSPase-like; KEGG: amt:Amet_1228 HAD family hydrolase. (243 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (449 aa) |
| | AEE90339.1 | UPF0597 protein yhaM; HAMAP: Uncharacterised protein family UPF0597; KEGG: cbf:CLI_1810 hypothetical protein; Belongs to the UPF0597 family. (429 aa) |
| | AEE90326.1 | TIGRFAM: Methylaspartate ammonia-lyase; KEGG: hor:Hore_15430 methylaspartate ammonia-lyase; PFAM: Methylaspartate ammonia-lyase, C-terminal; Methylaspartate ammonia-lyase, N-terminal. (413 aa) |
| | glmE | Methylaspartate mutase, E subunit; Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). (484 aa) |
| | mamA | Methylaspartate mutase S chain; Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). (140 aa) |
| | AEE90308.1 | HI0933 family protein; KEGG: dsy:DSY2873 hypothetical protein; TIGRFAM: Conserved hypothetical protein CHP00275, flavoprotein HI0933-like; PFAM: Conserved hypothetical protein CHP00275, flavoprotein HI0933-like. (413 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (284 aa) |
| | AEE90286.1 | PFAM: Radical SAM; KEGG: toc:Toce_0030 radical SAM domain protein. (198 aa) |
| | metG | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (650 aa) |
| | AEE90277.1 | KEGG: cpy:Cphy_3245 hypothetical protein. (228 aa) |
| | abgA | Amidohydrolase; TIGRFAM: Peptidase M20D, amidohydrolase; KEGG: sth:STH1690 putative amino acid amidohydrolase; PFAM: Peptidase M20; Peptidase M20, dimerisation. (429 aa) |
| | AEE90272.1 | Amidohydrolase; TIGRFAM: Peptidase M20D, amidohydrolase; KEGG: ctc:CTC02397 N-acyl-L-amino acid amidohydrolase; PFAM: Peptidase M20; Peptidase M20, dimerisation. (395 aa) |
| | AEE90262.1 | PFAM: Alanine racemase, N-terminal; KEGG: fnu:FN0552 serine racemase. (371 aa) |
| | proI | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (283 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | AEE92706.1 | KEGG: toc:Toce_2001 cobalamin synthesis protein P47K. (436 aa) |
| | AEE92694.1 | Methionine synthase; KEGG: str:Sterm_3081 homocysteine S-methyltransferase; PFAM: Homocysteine S-methyltransferase; Pterin-binding; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding. (793 aa) |
| | AEE92693.1 | PFAM: Vitamin B12-dependent methionine synthase, activation domain; KEGG: cbe:Cbei_1401 vitamin B12 dependent methionine synthase, activation region. (223 aa) |
| | AEE92691.1 | PFAM: Domain of unknown function DUF39; KEGG: elm:ELI_3644 protein of unknown function DUF39. (393 aa) |
| | AEE92647.1 | UPF0597 protein yhaM; HAMAP: Uncharacterised protein family UPF0597; KEGG: ctc:CTC02309 hypothetical protein; Belongs to the UPF0597 family. (424 aa) |
| | AEE92644.1 | HAMAP: Dihydrodipicolinate synthase; KEGG: aco:Amico_1768 dihydrodipicolinate synthetase; PFAM: Dihydrodipicolinate synthetase; Belongs to the DapA family. (304 aa) |
| | AEE92640.1 | L-iditol 2-dehydrogenase; KEGG: str:Sterm_0656 alcohol dehydrogenase GroES domain protein; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like. (345 aa) |
| | ilvH-2 | KEGG: mbu:Mbur_0709 acetolactate synthase 3 regulatory subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (178 aa) |
| | ilvD-2 | PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: clj:CLJU_c20410 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (552 aa) |
| | glsA | PFAM: Glutaminase; TIGRFAM: Glutaminase; HAMAP: Glutaminase; KEGG: ctc:CTC00566 glutaminase; Belongs to the glutaminase family. (300 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (143 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa) |
| | aroE-2 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa) |
| | AEE92575.1 | TIGRFAM: Chorismate mutase, Gram-positive; PFAM: Chorismate mutase, type II; KEGG: clj:CLJU_c29130 bifunctional chorismate mutase/prephenate dehydratase; SMART: Chorismate mutase. (92 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (369 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (434 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (355 aa) |
| | AEE92571.1 | KEGG: cno:NT01CX_0626 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase. (294 aa) |
| | aroF | TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; KEGG: cbk:CLL_A3144 3-deoxy-7-phosphoheptulonate synthase; PFAM: DAHP synthetase I/KDSA. (337 aa) |
| | pheA | KEGG: tpd:Teth39_0983 prephenate dehydratase; PFAM: Prephenate dehydratase; Amino acid-binding ACT. (279 aa) |
| | pyrB | PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; HAMAP: Aspartate carbamoyltransferase, eukaryotic; KEGG: tjr:TherJR_1833 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa) |
| | pyrAB | SMART: Methylglyoxal synthase-like domain; TIGRFAM: Carbamoyl-phosphate synthase, large subunit; KEGG: tjr:TherJR_1830 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthase, large subunit, N-terminal; Carbamoyl-phosphate synthetase, large subunit, oligomerisation; Methylglyoxal synthase-like domain; Belongs to the CarB family. (1063 aa) |
| | argS | KEGG: toc:Toce_2184 arginyl-tRNA synthetase; TIGRFAM: Arginyl-tRNA synthetase, class Ic; HAMAP: Arginyl-tRNA synthetase, class Ic. (569 aa) |
| | AEE92559.1 | KEGG: toc:Toce_2182 Zn-dependent hydrolase. (212 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (535 aa) |
| | AEE92548.1 | KEGG: cth:Cthe_1741 hypothetical protein. (83 aa) |
| | AEE92547.1 | KEGG: ckr:CKR_2362 hypothetical protein. (93 aa) |
| | glcD | D-lactate dehydrogenase (cytochrome); KEGG: tte:TTE0224 FAD/FMN-containing dehydrogenase; PFAM: FAD-linked oxidase, C-terminal; FAD linked oxidase, N-terminal. (473 aa) |
| | AEE92466.1 | PFAM: Acyl-ACP thioesterase; KEGG: chy:CHY_0816 acyl carrier protein thioesterase-like protein. (249 aa) |
| | tnaA | HAMAP: Tryptophanase; KEGG: cno:NT01CX_2071 tryptophanase; PFAM: Aromatic amino acid beta-eliminating lyase/threonine aldolase. (460 aa) |
| | leuC-3 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (423 aa) |
| | leuD-3 | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (173 aa) |
| | AEE92400.1 | MmgE/PrpD family protein; PFAM: MmgE/PrpD; KEGG: aco:Amico_0138 MmgE/PrpD family protein. (451 aa) |
| | mii-2 | PFAM: PrpF protein; KEGG: afn:Acfer_0629 protein of unknown function DUF453. (382 aa) |
| | AEE92398.1 | PFAM: PrpF protein; KEGG: efe:EFER_3666 hypothetical protein. (376 aa) |
| | AEE92397.1 | KEGG: efe:EFER_3668 putative isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. (389 aa) |
| | citD | Citrate lyase acyl carrier protein; Covalent carrier of the coenzyme of citrate lyase. (97 aa) |
| | AEE92377.1 | TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: dtu:Dtur_0617 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (155 aa) |
| | AEE92376.1 | TIGRFAM: Dihydropteroate synthase; KEGG: dth:DICTH_0461 dihydropteroate synthase; PFAM: Pterin-binding. (396 aa) |
| | tpiA-2 | TIGRFAM: Triosephosphate isomerase; KEGG: asu:Asuc_1575 triosephosphate isomerase; PFAM: Triosephosphate isomerase. (267 aa) |
| | AEE92332.1 | KEGG: nml:Namu_0013 ribulose-bisphosphate carboxylase; PFAM: Ribulose bisphosphate carboxylase, large subunit, C-terminal; Belongs to the RuBisCO large chain family. (427 aa) |
| | pfp-2 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (393 aa) |
| | AEE92328.1 | Protein of unknown function DUF129; PFAM: F420-0 gamma-glutamyl ligase-related; KEGG: nth:Nther_1219 hypothetical protein. (515 aa) |
| | AEE92324.1 | KEGG: toc:Toce_2140 pyruvate ferredoxin oxidoreductase, delta subunit; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate; PFAM: 4Fe-4S binding domain. (122 aa) |
| | porB | Pyruvate synthase; KEGG: toc:Toce_2138 thiamine pyrophosphate protein domain protein TPP-binding protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (315 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (233 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (159 aa) |
| | cysE | KEGG: toc:Toce_2115 serine O-acetyltransferase; TIGRFAM: Serine O-acetyltransferase. (224 aa) |
| | cysS | SMART: Cysteinyl-tRNA synthetase, class Ia, DALR; TIGRFAM: Cysteinyl-tRNA synthetase, class Ia; KEGG: toc:Toce_2114 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase, class Ia; Cysteinyl-tRNA synthetase, class Ia, DALR; Belongs to the class-I aminoacyl-tRNA synthetase family. (466 aa) |
| | AEE92268.1 | Phosphoglycerate dehydrogenase; KEGG: ate:Athe_1994 D-isomer specific 2-hydroxyacid dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (365 aa) |
| | AEE92267.1 | TIGRFAM: Ketose-bisphosphate aldolase, class-II; KEGG: ate:Athe_1995 ketose-bisphosphate aldolase; PFAM: Ketose-bisphosphate aldolase, class-II. (279 aa) |
| | AEE92262.1 | L-iditol 2-dehydrogenase; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; KEGG: sca:Sca_2417 putative zinc-binding dehydrogenase; SMART: Polyketide synthase, enoylreductase. (328 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (272 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (414 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | nanE | N-acetylmannosamine-6-phosphate 2-epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (240 aa) |
| | fabZ | (3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (142 aa) |
| | tyrS | Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (409 aa) |
| | AEE92167.1 | Histidinol-phosphate transaminase; KEGG: tsi:TSIB_1557 hypothetical protein; PFAM: Aminotransferase, class I/classII. (377 aa) |
| | AEE92142.1 | PFAM: Creatininase; KEGG: bha:BH0226 creatinine amidohydrolase. (239 aa) |
| | ydbK | SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; KEGG: ttm:Tthe_2243 pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (1174 aa) |
| | asd-2 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (337 aa) |
| | AEE92111.1 | KEGG: tjr:TherJR_0357 aspartate kinase, monofunctional class; TIGRFAM: Aspartate kinase domain; PFAM: Aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (394 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (337 aa) |
| | pgk | HAMAP: Phosphoglycerate kinase; KEGG: toc:Toce_1853 phosphoglycerate kinase; PFAM: Phosphoglycerate kinase. (394 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | pgm | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | AEE92089.1 | KEGG: gym:GYMC10_2999 Asp/Glu/hydantoin racemase. (222 aa) |
| | AEE92080.1 | KEGG: afn:Acfer_0786 3-hydroxyacyl-CoA dehydrogenase NAD-binding protein; PFAM: 3-hydroxyacyl-CoA dehydrogenase, NAD binding; 3-hydroxyacyl-CoA dehydrogenase, C-terminal. (349 aa) |
| | ilvD | PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: swo:Swol_2147 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (554 aa) |
| | AEE92078.1 | Cyclase family protein; PFAM: Putative cyclase; KEGG: bca:BCE_0461 hypothetical protein. (211 aa) |
| | AEE92077.1 | Amidohydrolase; TIGRFAM: Peptidase M20D, amidohydrolase; KEGG: cbt:CLH_1367 thermostable carboxypeptidase 1; PFAM: Peptidase M20; Peptidase M20, dimerisation. (391 aa) |
| | ilvB-2 | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: drm:Dred_0284 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (557 aa) |
| | ilvH | KEGG: ate:Athe_0503 acetolactate synthase small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (167 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (511 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (424 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (167 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa) |
| | ilvB | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: tjr:TherJR_0360 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (560 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa) |
| | hisS | PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Anticodon-binding; TIGRFAM: Histidyl-tRNA synthetase, class IIa, subgroup; HAMAP: Histidyl-tRNA synthetase, class IIa, subgroup; KEGG: ctc:CTC01958 histidyl-tRNA synthetase. (438 aa) |
| | mdeA-2 | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: tmt:Tmath_1425 Cys/Met metabolism pyridoxal-phosphate-dependent protein. (393 aa) |
| | tpl | TIGRFAM: Tyrosine phenol-lyase; KEGG: csh:Closa_0252 tyrosine phenol-lyase; PFAM: Aromatic amino acid beta-eliminating lyase/threonine aldolase. (459 aa) |
| | ygeX | TIGRFAM: Diaminopropionate ammonia-lyase, subgroup; Diaminopropionate ammonia-lyase; KEGG: ppy:PPE_02233 diaminopropionate ammonia-lyase (diaminopropionatase); PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (410 aa) |
| | AEE91989.1 | PFAM: Peptidase M20; Peptidase M20, dimerisation; KEGG: clj:CLJU_c29950 putative deacetylase. (393 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (290 aa) |
| | AEE91958.1 | PFAM: MaoC-like dehydratase; KEGG: bmd:BMD_3608 MaoC like domain-containing protein. (137 aa) |
| | paaF | Enoyl-CoA hydratase/isomerase; PFAM: Crotonase, core; KEGG: tte:TTE0544 3-hydroxybutyryl-CoA dehydratase. (260 aa) |
| | AEE91953.1 | L-threonine 3-dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, C-terminal; KEGG: ckn:Calkro_0548 alcohol dehydrogenase zinc-binding domain protein; SMART: Polyketide synthase, enoylreductase. (364 aa) |
| | AEE91938.1 | KEGG: chd:Calhy_2201 dihydrodipicolinate synthetase; PFAM: Dihydrodipicolinate synthetase; Belongs to the DapA family. (292 aa) |
| | AEE91937.1 | KEGG: pmo:Pmob_0980 5-carboxymethyl-2-hydroxymuconate delta-isomerase; PFAM: Fumarylacetoacetase, C-terminal-like. (250 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (303 aa) |
| | AEE91928.1 | (S)-2-hydroxy-acid oxidase; KEGG: toc:Toce_0633 FMN-dependent alpha-hydroxy acid dehydrogenase; PFAM: FMN-dependent dehydrogenase. (337 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase 3; HAMAP: Beta-ketoacyl-acyl carrier protein synthase III (FabH); KEGG: swd:Swoo_1669 beta-ketoacyl-acyl-carrier-protein synthase I; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III. (340 aa) |
| | AEE91905.1 | KEGG: bpr:GBP346_A4064 3-oxoacyl-[acyl-carrier-protein (ACP)] synthase III; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III. (352 aa) |
| | AEE91902.1 | Phosphopantetheine-protein transferase; KEGG: csc:Csac_1038 holo-acyl-carrier-protein synthase; TIGRFAM: Phosphopantethiene-protein transferase; PFAM: 4'-phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. (128 aa) |
| | AEE91886.1 | Phosphoglycerate dehydrogenase; KEGG: tmt:Tmath_0226 glyoxylate reductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (310 aa) |
| | gndA | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (470 aa) |
| | AEE91863.1 | LmbE family protein; PFAM: N-acetylglucosaminyl phosphatidylinositol deacetylase; KEGG: ttr:Tter_2570 LmbE family protein. (226 aa) |
| | yfeU | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (300 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (511 aa) |
| | AEE91841.1 | KEGG: toc:Toce_0363 hypothetical protein; Belongs to the arginase family. (251 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (491 aa) |
| | fba | TIGRFAM: Fructose-1,6-bisphosphate aldolase, class 2; Ketose-bisphosphate aldolase, class-II; KEGG: toc:Toce_1810 fructose-bisphosphate aldolase; PFAM: Ketose-bisphosphate aldolase, class-II. (309 aa) |
| | AEE91817.1 | KEGG: gym:GYMC10_0564 glucosamine-6-phosphate deaminase; PFAM: Glucosamine/galactosamine-6-phosphate isomerase. (253 aa) |
| | AEE91803.1 | PFAM: Amidohydrolase 1; KEGG: ccs:CCNA_00302 parathion hydrolase. (402 aa) |
| | trpE | Anthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (492 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (335 aa) |
| | trpC | KEGG: bpb:bpr_I0011 indole-3-glycerol phosphate synthase TrpC; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (260 aa) |
| | trpF | KEGG: cce:Ccel_3217 N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (202 aa) |
| | trpB-2 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa) |
| | iscS | Cysteine desulfurase; KEGG: toc:Toce_1465 aminotransferase class V; PFAM: Aminotransferase, class V/Cysteine desulfurase. (386 aa) |
| | AEE91731.1 | KEGG: dat:HRM2_29090 hypothetical protein. (242 aa) |
| | uxaA | PFAM: D-galactarate dehydratase/Altronate hydrolase, C-terminal; SAF domain; KEGG: cac:CA_C0696 putative altronate dehydratase; SMART: SAF domain. (495 aa) |
| | AEE91707.1 | Hexokinase; KEGG: ssm:Spirs_3985 hexokinase; PFAM: Hexokinase, C-terminal; Hexokinase, N-terminal. (436 aa) |
| | ald | TIGRFAM: Alanine dehydrogenase/pyridine nucleotide transhydrogenase; KEGG: toc:Toce_1453 L-alanine dehydrogenase; PFAM: Alanine dehydrogenase/PNT, C-terminal; Alanine dehydrogenase/PNT, N-terminal. (374 aa) |
| | ltaA | KEGG: toc:Toce_0664 L-threonine aldolase; PFAM: Aromatic amino acid beta-eliminating lyase/threonine aldolase. (344 aa) |
| | tdh | L-threonine 3-dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, C-terminal; KEGG: aba:Acid345_3920 L-threonine 3-dehydrogenase; SMART: Polyketide synthase, enoylreductase. (347 aa) |
| | AEE91693.1 | L-iditol 2-dehydrogenase; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; KEGG: gmc:GY4MC1_2525 alcohol dehydrogenase GroES domain protein; SMART: Polyketide synthase, enoylreductase. (329 aa) |
| | leuS | TIGRFAM: Leucyl-tRNA synthetase, class Ia, bacterial/mitochondrial; KEGG: toc:Toce_0772 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (816 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (517 aa) |
| | valS | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (883 aa) |
| | hom | PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; KEGG: tmt:Tmath_2179 homoserine dehydrogenase. (423 aa) |
| | thrC | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (353 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (296 aa) |
| | coaBC | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (149 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (590 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (876 aa) |
| | serA | TIGRFAM: D-3-phosphoglycerate dehydrogenase; KEGG: dau:Daud_0012 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Amino acid-binding ACT. (523 aa) |
| | argR | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (148 aa) |
| | AEE91514.1 | KEGG: toc:Toce_1258 CoA-substrate-specific enzyme activase; TIGRFAM: CoA enzyme activase; PFAM: ATPase, BadF/BadG/BcrA/BcrD type. (321 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (444 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (327 aa) |
| | AEE91498.1 | PFAM: NADP oxidoreductase, coenzyme F420-dependent; KEGG: gur:Gura_2528 hypothetical protein. (223 aa) |
| | AEE91496.1 | PFAM: GCN5-related N-acetyltransferase (GNAT) domain; Mitochondrial protein Pet127; KEGG: sul:SYO3AOP1_0115 GCN5-related N-acetyltransferase. (154 aa) |
| | AEE91491.1 | KEGG: toc:Toce_1153 HI0933 family protein; TIGRFAM: Conserved hypothetical protein CHP00275, flavoprotein HI0933-like; PFAM: Conserved hypothetical protein CHP00275, flavoprotein HI0933-like. (412 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (668 aa) |
| | gcdC | PFAM: Biotin/lipoyl attachment; KEGG: toc:Toce_1194 biotin/lipoyl attachment domain-containing protein. (128 aa) |
| | AEE91456.1 | Sodium pump decarboxylase, gamma subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the OadG family. (118 aa) |
| | yqjD | KEGG: toc:Toce_1831 propionyl-CoA carboxylase carboxyltransferase subunit; PFAM: Carboxyl transferase. (517 aa) |
| | mamA-2 | KEGG: toc:Toce_1199 cobalamin B12-binding domain protein; TIGRFAM: Methylmalonyl-CoA mutase, C-terminal; PFAM: Cobalamin (vitamin B12)-binding. (139 aa) |
| | gluD | PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain; KEGG: toc:Toce_1201 glutamate dehydrogenase (NAD); SMART: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (421 aa) |
| | korB | KEGG: toc:Toce_1203 2-oxoglutarate ferredoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (275 aa) |
| | AEE91424.1 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (401 aa) |
| | proS | Prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (478 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (358 aa) |
| | fabF | 3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa) |
| | acpA | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa) |
| | fabD | SMART: Polyketide synthase, acyl transferase domain; TIGRFAM: Malonyl CoA-acyl carrier protein transacylase; KEGG: toc:Toce_1056 (acyl-carrier-protein) S-malonyltransferase; PFAM: Acyl transferase. (311 aa) |
| | fabHA | 3-oxoacyl-(acyl-carrier-protein) synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (326 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (328 aa) |
| | ppdK | TIGRFAM: Pyruvate, phosphate dikinase; KEGG: toc:Toce_0928 pyruvate phosphate dikinase; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile domain; PEP-utilising enzyme; Belongs to the PEP-utilizing enzyme family. (879 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (251 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (468 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (241 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (421 aa) |
| | rocD | Acetylornithine/succinyldiaminopimelate aminotransferase; Catalyzes the interconversion of ornithine to glutamate semialdehyde. (396 aa) |
| | dsdA | D-serine dehydratase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; TIGRFAM: D-serine ammonia-lyase; HAMAP: D-serine dehydratase; KEGG: bca:BCE_1855 D-serine dehydratase; Belongs to the serine/threonine dehydratase family. DsdA subfamily. (444 aa) |
| | AEE91039.1 | KEGG: toc:Toce_1555 histidinol phosphate phosphatase HisJ family; TIGRFAM: Histidinol phosphate phosphatase, HisJ; PFAM: PHP, C-terminal; Belongs to the PHP hydrolase family. HisK subfamily. (275 aa) |
| | mdeA | TIGRFAM: Methionine gamma-lyase; KEGG: toc:Toce_1559 methionine gamma-lyase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme. (399 aa) |
| | AEE91028.1 | KEGG: toc:Toce_0567 hypothetical protein. (156 aa) |
| | hutI | Imidazolonepropionase; PFAM: Amidohydrolase 1; TIGRFAM: Imidazolonepropionase; HAMAP: Imidazolonepropionase; KEGG: toc:Toce_1473 imidazolonepropionase. (419 aa) |
| | AEE90960.1 | TIGRFAM: Formiminotransferase catalytic domain; KEGG: toc:Toce_1474 glutamate formiminotransferase; PFAM: Formiminotransferase, N-terminal subdomain; Formiminotransferase, C-terminal subdomain. (299 aa) |
| | uroc | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (683 aa) |
| | hutH | PFAM: Phenylalanine/histidine ammonia-lyase; TIGRFAM: Histidine ammonia-lyase; Tyrosine 2,3-aminomutase, putative; HAMAP: Histidine ammonia-lyase; KEGG: toc:Toce_1476 histidine ammonia-lyase. (511 aa) |
| | AEE90956.1 | KEGG: gym:GYMC10_2835 hypothetical protein. (264 aa) |
| | cysK | TIGRFAM: Cysteine synthase A; Cysteine synthase K/M; KEGG: toc:Toce_0731 cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (312 aa) |
| | gatY | TIGRFAM: Fructose-1,6-bisphosphate aldolase, class 2; Ketose-bisphosphate aldolase, class-II; KEGG: hor:Hore_22740 ketose-bisphosphate aldolase; PFAM: Ketose-bisphosphate aldolase, class-II. (281 aa) |
| | AEE90930.1 | Glucokinase, ROK family; TIGRFAM: Glucokinase ROK; KEGG: tjr:TherJR_2721 ROK family protein; PFAM: ROK. (318 aa) |
| | AEE90918.1 | C_GCAxxG_C_C family protein; KEGG: cpr:CPR_2280 hypothetical protein; TIGRFAM: CGCAxxGCC motif; PFAM: CGCAxxGCC motif. (135 aa) |
| | AEE90917.1 | PFAM: CobB/CobQ-like glutamine amidotransferase; KEGG: tte:TTE0007 glutamine amidotransferase. (240 aa) |
| | AEE90914.1 | Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (432 aa) |
| | AEE90913.1 | KEGG: hor:Hore_16050 glucokinase; PFAM: ROK. (317 aa) |
| | pyk | TIGRFAM: Pyruvate kinase; KEGG: toc:Toce_0871 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, C-terminal-like. (479 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa) |
| | dat | D-amino acid aminotransferase; Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction. (283 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1045 aa) |
| | pheT | KEGG: toc:Toce_1396 phenylalanyl-tRNA synthetase beta subunit; TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; HAMAP: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial. (798 aa) |
| | pheS | TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, alpha subunit; HAMAP: Phenylalanyl-tRNA synthetase alpha chain 1, bacterial; KEGG: toc:Toce_1397 phenylalanyl-tRNA synthetase, alpha subunit; PFAM: Phenylalanyl-tRNA synthetase; Phenylalanyl-tRNA synthetase, class II, N-terminal. (338 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (636 aa) |
| | hisI | PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphohydrolase; Histidine biosynthesis bifunctional protein HisIE; KEGG: slp:Slip_0617 phosphoribosyl-ATP diphosphatase; In the N-terminal section; belongs to the PRA-CH family. (211 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ppy:PPE_00178 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (243 aa) |
| | hisB | HAMAP: Imidazoleglycerol-phosphate dehydratase; KEGG: ttm:Tthe_0562 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | hisC | PFAM: Aminotransferase, class I/classII; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: toc:Toce_1416 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (373 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (206 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (371 aa) |
| | AEE90840.1 | KEGG: ssm:Spirs_3463 creatinine amidohydrolase, putative. (373 aa) |
| | glyQS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (460 aa) |
| | AEE90832.1 | PFAM: 2-oxoacid dehydrogenase acyltransferase, catalytic domain; Biotin/lipoyl attachment; E3 binding; KEGG: toc:Toce_1430 catalytic domain of components of various dehydrogenase complexes. (439 aa) |
| | bkdAB | Pyruvate dehydrogenase (acetyl-transferring); PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; KEGG: toc:Toce_1431 transketolase central region; SMART: Transketolase-like, pyrimidine-binding domain. (325 aa) |
| | acoA | Pyruvate dehydrogenase (acetyl-transferring); KEGG: toc:Toce_1432 dehydrogenase E1 component; PFAM: Dehydrogenase, E1 component. (319 aa) |
| | AEE90808.1 | L-iditol 2-dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, C-terminal; KEGG: toc:Toce_1442 alcohol dehydrogenase GroES domain protein; SMART: Polyketide synthase, enoylreductase. (343 aa) |
| | AEE90807.1 | L-threonine 3-dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, C-terminal; KEGG: toc:Toce_1443 alcohol dehydrogenase GroES domain protein; SMART: Polyketide synthase, enoylreductase. (346 aa) |
| | paaK | Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (432 aa) |
| | AEE90751.1 | PFAM: Ferredoxin; KEGG: toc:Toce_0815 ferredoxin. (642 aa) |
| | gcvH-3 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa) |
| | AEE90748.1 | Dihydropteroate synthase DHPS; PFAM: Pterin-binding; KEGG: toc:Toce_0812 dihydropteroate synthase DhpS. (261 aa) |
| | AEE90743.1 | PFAM: Methylenetetrahydrofolate reductase; KEGG: toc:Toce_0807 methylenetetrahydrofolate reductase. (290 aa) |
| | AEE90741.1 | Bifunctional protein folD; HAMAP: Tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: toc:Toce_0805 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); methenyltetrahydrofolate cyclohydrolase; PFAM: Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain. (284 aa) |
| | AEE90687.1 | PFAM: Amidohydrolase 1; KEGG: toc:Toce_1909 amidohydrolase. (387 aa) |
| | ntpR | PFAM: Peptidase C26; KEGG: toc:Toce_1911 peptidase C26. (236 aa) |
| | alr-2 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (393 aa) |
| | acpS | Holo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (140 aa) |
| | pfp | Diphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (394 aa) |
