STRINGSTRING
fhs2 fhs2 fchA fchA folD folD AEE90510.1 AEE90510.1 gcvT gcvT fhs1 fhs1 AEE90741.1 AEE90741.1 AEE90743.1 AEE90743.1 AEE90960.1 AEE90960.1 fchA-2 fchA-2 purN purN purH purH fmt fmt glyA glyA thyX thyX AEE92694.1 AEE92694.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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fhs2HAMAP: Formate-tetrahydrofolate ligase, FTHFS; KEGG: clj:CLJU_c37650 formate-tetrahydrofolate ligase; PFAM: Formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family. (561 aa)
fchAKEGG: cdf:CD0719 methenyltetrahydrofolate cyclohydrolase; PFAM: Cyclodeaminase/cyclohydrolase. (210 aa)
folDBifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa)
AEE90510.1PFAM: Methylenetetrahydrofolate reductase; KEGG: clj:CLJU_c37610 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (291 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (354 aa)
fhs1HAMAP: Formate-tetrahydrofolate ligase, FTHFS; KEGG: toc:Toce_0802 formate-tetrahydrofolate ligase; PFAM: Formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family. (559 aa)
AEE90741.1Bifunctional protein folD; HAMAP: Tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: toc:Toce_0805 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); methenyltetrahydrofolate cyclohydrolase; PFAM: Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain. (284 aa)
AEE90743.1PFAM: Methylenetetrahydrofolate reductase; KEGG: toc:Toce_0807 methylenetetrahydrofolate reductase. (290 aa)
AEE90960.1TIGRFAM: Formiminotransferase catalytic domain; KEGG: toc:Toce_1474 glutamate formiminotransferase; PFAM: Formiminotransferase, N-terminal subdomain; Formiminotransferase, C-terminal subdomain. (299 aa)
fchA-2Methenyltetrahydrofolate cyclohydrolase; KEGG: dtu:Dtur_0698 formiminotransferase-cyclodeaminase; PFAM: Cyclodeaminase/cyclohydrolase. (206 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (228 aa)
purHBifunctional purine biosynthesis protein purH; KEGG: toc:Toce_1498 IMP cyclohydrolase; phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain; TIGRFAM: AICARFT/IMPCHase bienzyme; HAMAP: AICARFT/IMPCHase bienzyme; SMART: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain. (520 aa)
fmtMethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (312 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
thyXThymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (386 aa)
AEE92694.1Methionine synthase; KEGG: str:Sterm_3081 homocysteine S-methyltransferase; PFAM: Homocysteine S-methyltransferase; Pterin-binding; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding. (793 aa)
Your Current Organism:
Tepidanaerobacter acetatoxydans
NCBI taxonomy Id: 1209989
Other names: T. acetatoxydans Re1, Tepidanaerobacter acetatoxydans Re1, Tepidanaerobacter acetatoxydans str. Re1, Tepidanaerobacter acetatoxydans strain Re1, Tepidanaerobacter sp. Re1
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