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| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | proI | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (283 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (284 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (313 aa) |
| | aldB | PFAM: Aldehyde dehydrogenase domain; KEGG: ssm:Spirs_2638 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (491 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (449 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (363 aa) |
| | AEE90364.1 | Aconitate hydratase; TIGRFAM: Aconitase, putative; KEGG: csc:Csac_0750 aconitate hydratase; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Aconitase A/isopropylmalate dehydratase small subunit, swivel. (645 aa) |
| | IDH | KEGG: cac:CA_C0972 isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. (333 aa) |
| | AEE90367.1 | KEGG: toc:Toce_0067 phospholipid/glycerol acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase. (203 aa) |
| | AEE90371.1 | KEGG: toc:Toce_1803 L-threonine ammonia-lyase; TIGRFAM: Threonine dehydratase II; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Amino acid-binding ACT. (402 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (535 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa) |
| | purC | PFAM: SAICAR synthetase; KEGG: slp:Slip_0625 phosphoribosylaminoimidazolesuccinocarboxamide synthase. (226 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (321 aa) |
| | AEE90473.1 | KEGG: ols:Olsu_0672 tagatose-bisphosphate aldolase; PFAM: Ketose-bisphosphate aldolase, class-II. (277 aa) |
| | acoL | TIGRFAM: Dihydrolipoamide dehydrogenase; KEGG: elm:ELI_0377 hypothetical protein; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. (457 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (124 aa) |
| | AEE90532.1 | PFAM: Methyltransferase type 11; KEGG: cbi:CLJ_B0542 putative methlytransferase. (195 aa) |
| | ddh | Diaminopimelate dehydrogenase; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. (302 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (354 aa) |
| | gcvH-2 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa) |
| | gcvPA | Glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (443 aa) |
| | gcvPB | Glycine dehydrogenase (decarboxylating) subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (482 aa) |
| | sudA | TIGRFAM: Glutamate synthase (NADPH), homotetrameric; KEGG: tpd:Teth39_0216 glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (464 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (173 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (380 aa) |
| | AEE90600.1 | KEGG: nth:Nther_2160 hypothetical protein. (471 aa) |
| | leuC | KEGG: nth:Nther_2159 3-isopropylmalate dehydratase; TIGRFAM: Homoaconitase/3-isopropylmalate dehydratase, large subunit, prokaryotic; Homoaconitase/3-isopropylmalate dehydratase, large subunit, subgroup; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Belongs to the aconitase/IPM isomerase family. (405 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (178 aa) |
| | AEE90634.1 | Phosphoglycerate dehydrogenase; KEGG: elm:ELI_0529 hypothetical protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (343 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (436 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (293 aa) |
| | AEE90661.1 | TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; KEGG: tmt:Tmath_0432 uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole methylase; Tetrapyrrole biosynthesis, uroporphyrinogen III synthase. (509 aa) |
| | hemB | KEGG: ttm:Tthe_1595 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; Belongs to the ALAD family. (326 aa) |
| | AEE90663.1 | TIGRFAM: Sirohaem synthase, N-terminal; KEGG: tpd:Teth39_1888 glutamate-1-semialdehyde-2,1-aminomutase. (189 aa) |
| | hemL | Glutamate-1-semialdehyde 2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; HAMAP: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; KEGG: thx:Thet_0364 glutamate-1-semialdehyde-2,1-aminomutase. (425 aa) |
| | pfp | Diphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (394 aa) |
| | fumA | TIGRFAM: Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain; KEGG: toc:Toce_1826 fumarase alpha subunit; PFAM: Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain. (281 aa) |
| | fumB | TIGRFAM: Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain; KEGG: toc:Toce_1825 hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain. (185 aa) |
| | fumA-2 | TIGRFAM: Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain; KEGG: kpn:KPN_00761 fumarate hydratase; PFAM: Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain. (281 aa) |
| | fumB-2 | TIGRFAM: Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain; KEGG: see:SNSL254_A0825 fumarate hydratase I, beta subunit; PFAM: Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain. (182 aa) |
| | LPD | TIGRFAM: Dihydrolipoamide dehydrogenase; KEGG: toc:Toce_0808 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. (460 aa) |
| | gcvH-3 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa) |
| | plsY | Glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (197 aa) |
| | AEE90760.1 | PFAM: FAD dependent oxidoreductase; BFD-like [2Fe-2S]-binding domain; KEGG: tit:Thit_1800 FAD dependent oxidoreductase. (490 aa) |
| | AEE90775.1 | KEGG: toc:Toce_1798 mannose-1-phosphate guanylyltransferase; PFAM: Nucleotidyl transferase; Mannose-6-phosphate isomerase, type II, C-terminal. (358 aa) |
| | AEE90832.1 | PFAM: 2-oxoacid dehydrogenase acyltransferase, catalytic domain; Biotin/lipoyl attachment; E3 binding; KEGG: toc:Toce_1430 catalytic domain of components of various dehydrogenase complexes. (439 aa) |
| | acoL-2 | TIGRFAM: Dihydrolipoamide dehydrogenase; KEGG: toc:Toce_1429 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. (460 aa) |
| | yrbE | KEGG: aap:NT05HA_1322 inositol 2-dehydrogenase; PFAM: Oxidoreductase, N-terminal; Oxidoreductase, C-terminal. (335 aa) |
| | algC | PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain III; Alpha-D-phosphohexomutase, C-terminal; KEGG: toc:Toce_0825 phosphomannomutase. (451 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (371 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (206 aa) |
| | hisC | PFAM: Aminotransferase, class I/classII; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: toc:Toce_1416 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (373 aa) |
| | hisB | HAMAP: Imidazoleglycerol-phosphate dehydratase; KEGG: ttm:Tthe_0562 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ppy:PPE_00178 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (243 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | hisI | PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphohydrolase; Histidine biosynthesis bifunctional protein HisIE; KEGG: slp:Slip_0617 phosphoribosyl-ATP diphosphatase; In the N-terminal section; belongs to the PRA-CH family. (211 aa) |
| | AEE90878.1 | TIGRFAM: Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase; KEGG: toc:Toce_0846 bifunctional phosphoglucose/phosphomannose isomerase; PFAM: Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase, C-terminal; Sugar isomerase (SIS). (351 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa) |
| | pyk | TIGRFAM: Pyruvate kinase; KEGG: toc:Toce_0871 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, C-terminal-like. (479 aa) |
| | AEE90913.1 | KEGG: hor:Hore_16050 glucokinase; PFAM: ROK. (317 aa) |
| | AEE90930.1 | Glucokinase, ROK family; TIGRFAM: Glucokinase ROK; KEGG: tjr:TherJR_2721 ROK family protein; PFAM: ROK. (318 aa) |
| | AEE90932.1 | KEGG: hor:Hore_22730 bifunctional phosphoglucose/phosphomannose isomerase; TIGRFAM: Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase; PFAM: Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase, C-terminal; Sugar isomerase (SIS). (357 aa) |
| | cysK | TIGRFAM: Cysteine synthase A; Cysteine synthase K/M; KEGG: toc:Toce_0731 cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (312 aa) |
| | AEE91039.1 | KEGG: toc:Toce_1555 histidinol phosphate phosphatase HisJ family; TIGRFAM: Histidinol phosphate phosphatase, HisJ; PFAM: PHP, C-terminal; Belongs to the PHP hydrolase family. HisK subfamily. (275 aa) |
| | rocD | Acetylornithine/succinyldiaminopimelate aminotransferase; Catalyzes the interconversion of ornithine to glutamate semialdehyde. (396 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (82 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (241 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (737 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (468 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein; manually curated; KEGG: toc:Toce_1500 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase. (344 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (228 aa) |
| | purH | Bifunctional purine biosynthesis protein purH; KEGG: toc:Toce_1498 IMP cyclohydrolase; phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain; TIGRFAM: AICARFT/IMPCHase bienzyme; HAMAP: AICARFT/IMPCHase bienzyme; SMART: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain. (520 aa) |
| | purD | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: toc:Toce_1497 phosphoribosylamine--glycine ligase; Belongs to the GARS family. (417 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (251 aa) |
| | hemN | Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (375 aa) |
| | AEE91259.1 | PFAM: Diacylglycerol kinase, prokaryotic; KEGG: toc:Toce_0922 diacylglycerol kinase. (125 aa) |
| | ppdK | TIGRFAM: Pyruvate, phosphate dikinase; KEGG: toc:Toce_0928 pyruvate phosphate dikinase; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile domain; PEP-utilising enzyme; Belongs to the PEP-utilizing enzyme family. (879 aa) |
| | gpsA | KEGG: toc:Toce_0979 glycerol 3-phosphate dehydrogenase (NAD(P)+); HAMAP: Glycerol-3-phosphate dehydrogenase, NAD-dependent; PFAM: Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal; Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal. (344 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (328 aa) |
| | fabD | SMART: Polyketide synthase, acyl transferase domain; TIGRFAM: Malonyl CoA-acyl carrier protein transacylase; KEGG: toc:Toce_1056 (acyl-carrier-protein) S-malonyltransferase; PFAM: Acyl transferase. (311 aa) |
| | fabG | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa) |
| | acpA | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa) |
| | ispU | Undecaprenyl pyrophosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (252 aa) |
| | AEE91405.1 | PFAM: Phosphatidate cytidylyltransferase; KEGG: toc:Toce_1252 phosphatidate cytidylyltransferase; Belongs to the CDS family. (270 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (358 aa) |
| | AEE91420.1 | Riboflavin biosynthesis protein RibF; SMART: Riboflavin kinase; TIGRFAM: Riboflavin kinase/FAD synthetase; KEGG: toc:Toce_1233 riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase. (308 aa) |
| | AEE91446.1 | PFAM: 4Fe-4S binding domain; KEGG: toc:Toce_1205 4Fe-4S ferredoxin iron-sulfur binding domain protein. (68 aa) |
| | korA | KEGG: toc:Toce_1204 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal. (383 aa) |
| | korB | KEGG: toc:Toce_1203 2-oxoglutarate ferredoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (275 aa) |
| | korC | TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate; KEGG: toc:Toce_1202 2-oxoglutarate ferredoxin oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (177 aa) |
| | miaA | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (314 aa) |
| | AEE91476.1 | Aspartate transaminase; KEGG: toc:Toce_1173 aminotransferase class I and II; PFAM: Aminotransferase, class I/classII. (400 aa) |
| | surE | Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa) |
| | fni | Isopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (348 aa) |
| | AEE91489.1 | KEGG: toc:Toce_1155 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase. (198 aa) |
| | AEE91496.1 | PFAM: GCN5-related N-acetyltransferase (GNAT) domain; Mitochondrial protein Pet127; KEGG: sul:SYO3AOP1_0115 GCN5-related N-acetyltransferase. (154 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (444 aa) |
| | crtE | PFAM: Polyprenyl synthetase; KEGG: toc:Toce_1308 farnesyl-diphosphate synthase. (296 aa) |
| | serA | TIGRFAM: D-3-phosphoglycerate dehydrogenase; KEGG: dau:Daud_0012 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Amino acid-binding ACT. (523 aa) |
| | AEE91589.1 | KEGG: toc:Toce_1367 von Willebrand factor type A; PFAM: von Willebrand factor, type A; SMART: von Willebrand factor, type A. (547 aa) |
| | AEE91590.1 | SMART: ATPase, AAA+ type, core; KEGG: toc:Toce_1368 magnesium chelatase. (439 aa) |
| | rpe | TIGRFAM: Ribulose-phosphate 3-epimerase; KEGG: toc:Toce_1033 ribulose-5-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3-epimerase. (216 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (296 aa) |
| | thrC | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (353 aa) |
| | hom | PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; KEGG: tmt:Tmath_2179 homoserine dehydrogenase. (423 aa) |
| | AEE91635.1 | KEGG: ttm:Tthe_2600 amino acid-binding ACT domain protein; HAMAP: Ligand-binding-predicted, ACT; PFAM: Amino acid-binding ACT; Belongs to the UPF0735 family. (147 aa) |
| | AEE91640.1 | Trans-hexaprenyltranstransferase; KEGG: toc:Toce_1730 polyprenyl synthetase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (326 aa) |
| | AEE91688.1 | PFAM: Heptaprenyl diphosphate synthase component I; KEGG: toc:Toce_0736 heptaprenyl diphosphate synthase component I. (171 aa) |
| | ltaA | KEGG: toc:Toce_0664 L-threonine aldolase; PFAM: Aromatic amino acid beta-eliminating lyase/threonine aldolase. (344 aa) |
| | AEE91707.1 | Hexokinase; KEGG: ssm:Spirs_3985 hexokinase; PFAM: Hexokinase, C-terminal; Hexokinase, N-terminal. (436 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa) |
| | trpB-2 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpF | KEGG: cce:Ccel_3217 N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (202 aa) |
| | trpC | KEGG: bpb:bpr_I0011 indole-3-glycerol phosphate synthase TrpC; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (260 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (335 aa) |
| | trpG | TIGRFAM: Anthranilate synthase, glutamine amidotransferase domain; KEGG: ere:EUBREC_2979 anthranilate/para-aminobenzoate synthase component II, TrpG; PFAM: Glutamine amidotransferase class-I, C-terminal. (194 aa) |
| | trpE | Anthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (492 aa) |
| | AEE91784.1 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; KEGG: sfu:Sfum_3382 HAD family hydrolase; PFAM: Haloacid dehalogenase-like hydrolase. (217 aa) |
| | AEE91805.1 | 1-deoxy-D-xylulose-5-phosphate synthase; PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; KEGG: toc:Toce_1701 transketolase subunit B; SMART: Transketolase-like, pyrimidine-binding domain. (308 aa) |
| | AEE91806.1 | Transketolase; KEGG: toc:Toce_1702 transketolase subunit A; PFAM: Transketolase, N-terminal. (273 aa) |
| | fba | TIGRFAM: Fructose-1,6-bisphosphate aldolase, class 2; Ketose-bisphosphate aldolase, class-II; KEGG: toc:Toce_1810 fructose-bisphosphate aldolase; PFAM: Ketose-bisphosphate aldolase, class-II. (309 aa) |
| | AEE91829.1 | Cystathionine beta-lyase; KEGG: kol:Kole_0146 aminotransferase class I and II; PFAM: Aminotransferase, class I/classII. (390 aa) |
| | metK | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (398 aa) |
| | fbp | Protein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (362 aa) |
| | gndA | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (470 aa) |
| | AEE91885.1 | Gluconokinase; KEGG: mcu:HMPREF0573_10635 gluconokinase; PFAM: Carbohydrate kinase, FGGY, N-terminal; Carbohydrate kinase, FGGY, C-terminal; Belongs to the FGGY kinase family. (482 aa) |
| | AEE91886.1 | Phosphoglycerate dehydrogenase; KEGG: tmt:Tmath_0226 glyoxylate reductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (310 aa) |
| | AEE91906.1 | KEGG: mch:Mchl_3032 hypothetical protein. (76 aa) |
| | AEE91928.1 | (S)-2-hydroxy-acid oxidase; KEGG: toc:Toce_0633 FMN-dependent alpha-hydroxy acid dehydrogenase; PFAM: FMN-dependent dehydrogenase. (337 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (303 aa) |
| | AEE91938.1 | KEGG: chd:Calhy_2201 dihydrodipicolinate synthetase; PFAM: Dihydrodipicolinate synthetase; Belongs to the DapA family. (292 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (290 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (156 aa) |
| | ribAB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (400 aa) |
| | ribE | Riboflavin synthase, alpha subunit; TIGRFAM: Lumazine-binding protein; KEGG: toc:Toce_1694 riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. (212 aa) |
| | ribD | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (361 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa) |
| | ilvB | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: tjr:TherJR_0360 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (560 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (167 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (424 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (511 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa) |
| | ilvH | KEGG: ate:Athe_0503 acetolactate synthase small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (167 aa) |
| | ilvB-2 | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: drm:Dred_0284 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (557 aa) |
| | ilvD | PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: swo:Swol_2147 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (554 aa) |
| | AEE92082.1 | 1-deoxy-D-xylulose-5-phosphate synthase; PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; KEGG: aar:Acear_0284 transketolase subunit B; SMART: Transketolase-like, pyrimidine-binding domain. (316 aa) |
| | AEE92083.1 | Transketolase; KEGG: cbe:Cbei_0545 transketolase domain-containing protein; PFAM: Transketolase, N-terminal. (272 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | pgm | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | gapA | SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: toc:Toce_1855 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain. (337 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (337 aa) |
| | AEE92111.1 | KEGG: tjr:TherJR_0357 aspartate kinase, monofunctional class; TIGRFAM: Aspartate kinase domain; PFAM: Aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (394 aa) |
| | asd-2 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (337 aa) |
| | ydbK | SMART: Pyruvate-flavodoxin oxidoreductase, EKR domain; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; KEGG: ttm:Tthe_2243 pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (1174 aa) |
| | pupG | Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa) |
| | ddh-2 | Diaminopimelate dehydrogenase; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. (301 aa) |
| | AEE92135.1 | PFAM: Saccharopine dehydrogenase / Homospermidine synthase; KEGG: dol:Dole_2976 saccharopine dehydrogenase. (368 aa) |
| | patB | Cystathionine beta-lyase; KEGG: kol:Kole_0146 aminotransferase class I and II; PFAM: Aminotransferase, class I/classII. (393 aa) |
| | AEE92167.1 | Histidinol-phosphate transaminase; KEGG: tsi:TSIB_1557 hypothetical protein; PFAM: Aminotransferase, class I/classII. (377 aa) |
| | AEE92216.1 | 1-deoxy-D-xylulose-5-phosphate synthase; PFAM: Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; KEGG: brm:Bmur_0244 transketolase central region; SMART: Transketolase-like, pyrimidine-binding domain. (310 aa) |
| | AEE92217.1 | Transketolase; KEGG: tmt:Tmath_1823 transketolase domain protein; PFAM: Transketolase, N-terminal. (281 aa) |
| | AEE92227.1 | Glucokinase; KEGG: pjd:Pjdr2_6213 ROK family protein; PFAM: ROK. (301 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | ywlF | Sugar-phosphate isomerase, RpiB/LacA/LacB family; TIGRFAM: Ribose/galactose isomerase; Ribose 5-phosphate isomerase B; KEGG: toc:Toce_2066 ribose-5-phosphate isomerase; PFAM: Ribose/galactose isomerase. (147 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (414 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (272 aa) |
| | hprT | TIGRFAM: Hypoxanthine phosphoribosyl transferase; KEGG: toc:Toce_2097 hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa) |
| | garK | TIGRFAM: Glycerate kinase; KEGG: chy:CHY_1268 glycerate kinase 2; PFAM: Glycerate kinase; Belongs to the glycerate kinase type-1 family. (379 aa) |
| | AEE92267.1 | TIGRFAM: Ketose-bisphosphate aldolase, class-II; KEGG: ate:Athe_1995 ketose-bisphosphate aldolase; PFAM: Ketose-bisphosphate aldolase, class-II. (279 aa) |
| | AEE92268.1 | Phosphoglycerate dehydrogenase; KEGG: ate:Athe_1994 D-isomer specific 2-hydroxyacid dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (365 aa) |
| | cysE | KEGG: toc:Toce_2115 serine O-acetyltransferase; TIGRFAM: Serine O-acetyltransferase. (224 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (159 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (233 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (482 aa) |
| | porB | Pyruvate synthase; KEGG: toc:Toce_2138 thiamine pyrophosphate protein domain protein TPP-binding protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (315 aa) |
| | porA | KEGG: toc:Toce_2139 pyruvate ferredoxin oxidoreductase, alpha subunit; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal. (393 aa) |
| | AEE92324.1 | KEGG: toc:Toce_2140 pyruvate ferredoxin oxidoreductase, delta subunit; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate; PFAM: 4Fe-4S binding domain. (122 aa) |
| | porC | TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate; KEGG: toc:Toce_2141 pyruvate ferredoxin oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain. (192 aa) |
| | pfp-2 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (393 aa) |
| | AEE92338.1 | PFAM: FAD dependent oxidoreductase; BFD-like [2Fe-2S]-binding domain; KEGG: elm:ELI_2864 hypothetical protein. (481 aa) |
| | AEE92340.1 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; KEGG: hor:Hore_03270 ribose-5-phosphate isomerase; TIGRFAM: Ribose/galactose isomerase; Ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. (154 aa) |
| | AEE92395.1 | KEGG: efe:EFER_3665 aconitate hydratase; TIGRFAM: Aconitase, putative; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Aconitase A/isopropylmalate dehydratase small subunit, swivel. (649 aa) |
| | ybhJ | 3-isopropylmalate dehydratase; KEGG: amt:Amet_3214 hypothetical protein; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Aconitase A/isopropylmalate dehydratase small subunit, swivel. (766 aa) |
| | AEE92397.1 | KEGG: efe:EFER_3668 putative isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. (389 aa) |
| | leuD-3 | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (173 aa) |
| | AEE92457.1 | KEGG: aco:Amico_1535 ornithine cyclodeaminase; PFAM: Ornithine cyclodeaminase/mu-crystallin. (338 aa) |
| | glcD | D-lactate dehydrogenase (cytochrome); KEGG: tte:TTE0224 FAD/FMN-containing dehydrogenase; PFAM: FAD-linked oxidase, C-terminal; FAD linked oxidase, N-terminal. (473 aa) |
| | patB-2 | Cystathionine beta-lyase; KEGG: aar:Acear_2286 aminotransferase class I and II; PFAM: Aminotransferase, class I/classII. (396 aa) |
| | pheA | KEGG: tpd:Teth39_0983 prephenate dehydratase; PFAM: Prephenate dehydratase; Amino acid-binding ACT. (279 aa) |
| | aroF | TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; KEGG: cbk:CLL_A3144 3-deoxy-7-phosphoheptulonate synthase; PFAM: DAHP synthetase I/KDSA. (337 aa) |
| | AEE92571.1 | KEGG: cno:NT01CX_0626 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase. (294 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (355 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (434 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (369 aa) |
| | aroE-2 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (143 aa) |
| | ilvD-2 | PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: clj:CLJU_c20410 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (552 aa) |
| | ilvH-2 | KEGG: mbu:Mbur_0709 acetolactate synthase 3 regulatory subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (178 aa) |
| | fba-2 | TIGRFAM: Ketose-bisphosphate aldolase, class-II; KEGG: toc:Toce_1875 ketose-bisphosphate aldolase; PFAM: Ketose-bisphosphate aldolase, class-II. (280 aa) |
| | AEE92644.1 | HAMAP: Dihydrodipicolinate synthase; KEGG: aco:Amico_1768 dihydrodipicolinate synthetase; PFAM: Dihydrodipicolinate synthetase; Belongs to the DapA family. (304 aa) |
| | AEE92694.1 | Methionine synthase; KEGG: str:Sterm_3081 homocysteine S-methyltransferase; PFAM: Homocysteine S-methyltransferase; Pterin-binding; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding. (793 aa) |
