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proC proC B277_00925 B277_00925 gabD2 gabD2 proA proA proB proB mmsA mmsA B277_05381 B277_05381 B277_05386 B277_05386 glnE glnE B277_06959 B277_06959 B277_06964 B277_06964 acs acs B277_08604 B277_08604 B277_09372 B277_09372 B277_09377 B277_09377 B277_10139 B277_10139 B277_10940 B277_10940 B277_11160 B277_11160 B277_11880 B277_11880 gltD gltD B277_13504 B277_13504 B277_13869 B277_13869 B277_16149 B277_16149
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (423 aa)
B277_00925COG0506 Proline dehydrogenase. (262 aa)
gabD2Succinic semialdehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases. (530 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (428 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (372 aa)
mmsACOG1012 NAD-dependent aldehyde dehydrogenases. (502 aa)
B277_05381COG0174 Glutamine synthetase. (88 aa)
B277_05386COG0174 Glutamine synthetase. (268 aa)
glnEBifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] (991 aa)
B277_06959COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (493 aa)
B277_06964COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (400 aa)
acsacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (643 aa)
B277_08604COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (427 aa)
B277_09372Ammonium transporter; COG0004 Ammonia permease. (460 aa)
B277_09377COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family. (112 aa)
B277_10139Class I and II aminotransferase; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (405 aa)
B277_10940COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (357 aa)
B277_11160COG0174 Glutamine synthetase. (259 aa)
B277_11880Glutamate synthase (NADH) large subunit; COG0067 Glutamate synthase domain 1. (1521 aa)
gltDGlutamate synthase (NADH) small subunit; COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. (485 aa)
B277_13504Succinate semialdehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (487 aa)
B277_13869COG0174 Glutamine synthetase. (539 aa)
B277_16149COG1012 NAD-dependent aldehyde dehydrogenases. (456 aa)
Your Current Organism:
Janibacter hoylei
NCBI taxonomy Id: 1210046
Other names: J. hoylei PVAS-1, Janibacter hoylei DSM 21601, Janibacter hoylei MTCC 8307, Janibacter hoylei PVAS-1, Janibacter hoylei str. PVAS-1, Janibacter hoylei strain PVAS-1, Janibacter sp. PVAS-1
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