STRINGSTRING
B277_00750 B277_00750 B277_01139 B277_01139 B277_01169 B277_01169 B277_01369 B277_01369 mdh mdh B277_01994 B277_01994 B277_01999 B277_01999 B277_02194 B277_02194 B277_02199 B277_02199 B277_02204 B277_02204 B277_02778 B277_02778 B277_04040 B277_04040 B277_04045 B277_04045 B277_04357 B277_04357 B277_04637 B277_04637 B277_04642 B277_04642 B277_05264 B277_05264 B277_05908 B277_05908 B277_06278 B277_06278 leuA leuA B277_06724 B277_06724 fumC fumC B277_06974 B277_06974 acs acs B277_07638 B277_07638 B277_07643 B277_07643 B277_08539 B277_08539 B277_08649 B277_08649 B277_08789 B277_08789 B277_09177 B277_09177 B277_09992 B277_09992 pckG pckG B277_10451 B277_10451 B277_10676 B277_10676 B277_10830 B277_10830 B277_11780 B277_11780 B277_11890 B277_11890 B277_12211 B277_12211 B277_12261 B277_12261 B277_12656 B277_12656 B277_12786 B277_12786 B277_12791 B277_12791 merA merA B277_13039 B277_13039 B277_13129 B277_13129 B277_13324 B277_13324 B277_13834 B277_13834 lpdA lpdA B277_14339 B277_14339 aceE aceE B277_14513 B277_14513 B277_14658 B277_14658 B277_15018 B277_15018 B277_15189 B277_15189 B277_15269 B277_15269 B277_16237 B277_16237
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
B277_00750Glyoxalase/bleomycin resistance protein/dioxygenase; COG0346 Lactoylglutathione lyase and related lyases. (107 aa)
B277_01139COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (429 aa)
B277_01169Glyoxalase/bleomycin resistance protein/dioxygenase; COG3324 Predicted enzyme related to lactoylglutathione lyase. (121 aa)
B277_01369FxsA cytoplasmic membrane protein; COG3030 Protein affecting phage T7 exclusion by the F plasmid. (163 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (331 aa)
B277_01994COG3564 Uncharacterized protein conserved in bacteria. (124 aa)
B277_01999COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (507 aa)
B277_02194COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (413 aa)
B277_02199COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (354 aa)
B277_02204Hypothetical protein; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (456 aa)
B277_02778Hemerythrin HHE cation binding domain-containing protein. (185 aa)
B277_04040COG0777 Acetyl-CoA carboxylase beta subunit. (356 aa)
B277_04045COG0825 Acetyl-CoA carboxylase alpha subunit. (285 aa)
B277_04357CoA-binding protein; COG1042 Acyl-CoA synthetase (NDP forming). (636 aa)
B277_046372-oxoglutarate synthase; COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. (366 aa)
B277_04642Pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit. (623 aa)
B277_05264Pyruvate carboxylase; COG0511 Biotin carboxyl carrier protein. (72 aa)
B277_05908COG2879 Uncharacterized small protein. (119 aa)
B277_06278COG2764 Uncharacterized protein conserved in bacteria. (135 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (579 aa)
B277_06724COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (521 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa)
B277_06974COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases. (329 aa)
acsacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (643 aa)
B277_07638COG0491 Zn-dependent hydrolases, including glyoxylases. (270 aa)
B277_07643NUDIX hydrolase; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. (281 aa)
B277_08539Malate dehydrogenase; COG0281 Malic enzyme. (491 aa)
B277_08649COG2764 Uncharacterized protein conserved in bacteria. (186 aa)
B277_08789Hydrolase; COG0491 Zn-dependent hydrolases, including glyoxylases. (308 aa)
B277_09177Biotin carboxyl carrier protein; COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit; biotin carboxylase. (588 aa)
B277_09992Beta-lactamase domain-containing protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (228 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (612 aa)
B277_10451COG1254 Acylphosphatases. (96 aa)
B277_10676Alpha-isopropylmalate/homocitrate synthase family transferase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. (526 aa)
B277_10830Malic protein NAD-binding protein; COG0281 Malic enzyme. (386 aa)
B277_11780Hypothetical protein; COG0346 Lactoylglutathione lyase and related lyases. (127 aa)
B277_11890COG0469 Pyruvate kinase; overlaps another CDS with the same product name. (526 aa)
B277_12211Thiamine pyrophosphate TPP-binding domain-containing protein; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (581 aa)
B277_12261Pyruvate phosphate dikinase; COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (899 aa)
B277_12656D-isomer specific 2-hydroxyacid dehydrogenase; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases. (308 aa)
B277_12786COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
B277_12791Carbamoyl-phosphate synthase L chain ATP-binding protein; COG0439 Biotin carboxylase; overlaps another CDS with the same product name. (748 aa)
merAMercuric reductase; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (466 aa)
B277_13039Glyoxalase/bleomycin resistance protein/dioxygenase; COG0346 Lactoylglutathione lyase and related lyases. (72 aa)
B277_13129FAD-binding dehydrogenase; COG3573 Predicted oxidoreductase. (547 aa)
B277_13324Mycothione reductase; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (474 aa)
B277_13834Succinate CoA transferase; COG0427 Acetyl-CoA hydrolase. (504 aa)
lpdACOG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (462 aa)
B277_14339COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (489 aa)
aceEPyruvate dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (930 aa)
B277_14513COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
B277_14658Putative oxidoreductase; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (469 aa)
B277_15018COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
B277_15189COG0183 Acetyl-CoA acetyltransferase. (110 aa)
B277_15269COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases. (438 aa)
B277_16237Glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein; COG3565 Predicted dioxygenase of extradiol dioxygenase family. (141 aa)
Your Current Organism:
Janibacter hoylei
NCBI taxonomy Id: 1210046
Other names: J. hoylei PVAS-1, Janibacter hoylei DSM 21601, Janibacter hoylei MTCC 8307, Janibacter hoylei PVAS-1, Janibacter hoylei str. PVAS-1, Janibacter hoylei strain PVAS-1, Janibacter sp. PVAS-1
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