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acnA acnA gltA gltA B277_00955 B277_00955 B277_01114 B277_01114 B277_01139 B277_01139 mdh mdh B277_01994 B277_01994 B277_02491 B277_02491 B277_02496 B277_02496 B277_05381 B277_05381 B277_05386 B277_05386 B277_05451 B277_05451 B277_06724 B277_06724 B277_06874 B277_06874 B277_06889 B277_06889 B277_06974 B277_06974 gcvH gcvH gcvP gcvP acs acs glyA glyA B277_08584 B277_08584 B277_09177 B277_09177 B277_09222 B277_09222 B277_09287 B277_09287 purU purU icmF icmF B277_10661 B277_10661 B277_11160 B277_11160 B277_11445 B277_11445 B277_12486 B277_12486 B277_12656 B277_12656 B277_12786 B277_12786 B277_12846 B277_12846 merA merA B277_13164 B277_13164 B277_13324 B277_13324 B277_13869 B277_13869 lpdA lpdA gcvT gcvT B277_14339 B277_14339 B277_14483 B277_14483 mce mce B277_14513 B277_14513 B277_14658 B277_14658 B277_14913 B277_14913 B277_15018 B277_15018 B277_15189 B277_15189 B277_16089 B277_16089
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
acnACOG1048 Aconitase A. (933 aa)
gltACOG0372 Citrate synthase; Belongs to the citrate synthase family. (427 aa)
B277_00955COG0277 FAD/FMN-containing dehydrogenases. (469 aa)
B277_01114Hypothetical protein. (318 aa)
B277_01139COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (429 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (331 aa)
B277_01994COG3564 Uncharacterized protein conserved in bacteria. (124 aa)
B277_02491COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (608 aa)
B277_02496COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (736 aa)
B277_05381COG0174 Glutamine synthetase. (88 aa)
B277_05386COG0174 Glutamine synthetase. (268 aa)
B277_05451COG0753 Catalase; Belongs to the catalase family. (520 aa)
B277_06724COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (521 aa)
B277_06874Formate dehydrogenase subunit alpha; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing. (190 aa)
B277_06889Formate dehydrogenase subunit beta; COG0437 Fe-S-cluster-containing hydrogenase components 1. (379 aa)
B277_06974COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases. (329 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (942 aa)
acsacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (643 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa)
B277_08584COG1393 Arsenate reductase and related proteins, glutaredoxin family; Belongs to the ArsC family. (118 aa)
B277_09177Biotin carboxyl carrier protein; COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit; biotin carboxylase. (588 aa)
B277_09222COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (520 aa)
B277_09287COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (546 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (291 aa)
icmFmethylmalonyl-CoA mutase large subunit; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1083 aa)
B277_10661Catalase; Serves to protect cells from the toxic effects of hydrogen peroxide. (701 aa)
B277_11160COG0174 Glutamine synthetase. (259 aa)
B277_11445Peptidase S66 family protein; COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF. (345 aa)
B277_12486HpcH/HpaI aldolase; COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. (356 aa)
B277_12656D-isomer specific 2-hydroxyacid dehydrogenase; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases. (308 aa)
B277_12786COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
B277_12846MaoC domain-containing protein dehydratase; COG2030 Acyl dehydratase. (143 aa)
merAMercuric reductase; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (466 aa)
B277_13164COG0372 Citrate synthase; Belongs to the citrate synthase family. (368 aa)
B277_13324Mycothione reductase; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (474 aa)
B277_13869COG0174 Glutamine synthetase. (539 aa)
lpdACOG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (462 aa)
gcvTGlycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. (369 aa)
B277_14339COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (489 aa)
B277_14483COG0247 Fe-S oxidoreductase. (240 aa)
mcemethylmalonyl-CoA epimerase; COG0346 Lactoylglutathione lyase and related lyases. (143 aa)
B277_14513COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
B277_14658Putative oxidoreductase; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (469 aa)
B277_14913Dehydratase; COG2030 Acyl dehydratase. (350 aa)
B277_15018COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
B277_15189COG0183 Acetyl-CoA acetyltransferase. (110 aa)
B277_16089COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (733 aa)
Your Current Organism:
Janibacter hoylei
NCBI taxonomy Id: 1210046
Other names: J. hoylei PVAS-1, Janibacter hoylei DSM 21601, Janibacter hoylei MTCC 8307, Janibacter hoylei PVAS-1, Janibacter hoylei str. PVAS-1, Janibacter hoylei strain PVAS-1, Janibacter sp. PVAS-1
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