STRINGSTRING
ectC ectC B277_00055 B277_00055 dapD dapD gltA gltA B277_00080 B277_00080 B277_00265 B277_00265 B277_00405 B277_00405 B277_00430 B277_00430 B277_00595 B277_00595 prs prs B277_00825 B277_00825 sdhA sdhA B277_00835 B277_00835 hemL hemL B277_00855 B277_00855 B277_00860 B277_00860 hemC hemC hemA hemA B277_00935 B277_00935 B277_00955 B277_00955 B277_01129 B277_01129 B277_01139 B277_01139 B277_01149 B277_01149 B277_01184 B277_01184 B277_01204 B277_01204 B277_01434 B277_01434 B277_01449 B277_01449 B277_01464 B277_01464 B277_01529 B277_01529 gabD2 gabD2 B277_01594 B277_01594 B277_01704 B277_01704 sucC sucC sucD sucD folD folD mdh mdh B277_01839 B277_01839 B277_01994 B277_01994 B277_01999 B277_01999 B277_02004 B277_02004 B277_02194 B277_02194 B277_02199 B277_02199 B277_02204 B277_02204 B277_02491 B277_02491 B277_02496 B277_02496 B277_02536 B277_02536 B277_02541 B277_02541 B277_02546 B277_02546 B277_02551 B277_02551 B277_02586 B277_02586 B277_02656 B277_02656 B277_02696 B277_02696 B277_02788 B277_02788 B277_02798 B277_02798 B277_02833 B277_02833 B277_03158 B277_03158 B277_03178 B277_03178 B277_03273 B277_03273 B277_03425 B277_03425 B277_03520 B277_03520 B277_03525 B277_03525 B277_03540 B277_03540 B277_03545 B277_03545 B277_03650 B277_03650 B277_03665 B277_03665 B277_03675 B277_03675 B277_04040 B277_04040 B277_04045 B277_04045 B277_04160 B277_04160 B277_04165 B277_04165 B277_04170 B277_04170 B277_04185 B277_04185 B277_04227 B277_04227 B277_04232 B277_04232 acnA acnA B277_04347 B277_04347 B277_04357 B277_04357 B277_04637 B277_04637 B277_04642 B277_04642 B277_04707 B277_04707 B277_04712 B277_04712 B277_04752 B277_04752 B277_04757 B277_04757 B277_05094 B277_05094 B277_05099 B277_05099 B277_05104 B277_05104 B277_05109 B277_05109 B277_05124 B277_05124 B277_05144 B277_05144 iolB iolB iolC iolC B277_05159 B277_05159 B277_05164 B277_05164 B277_05169 B277_05169 B277_05264 B277_05264 B277_05354 B277_05354 B277_05381 B277_05381 B277_05386 B277_05386 argD argD B277_05693 B277_05693 B277_05698 B277_05698 B277_05823 B277_05823 B277_05908 B277_05908 dapB dapB B277_05953 B277_05953 dapA dapA B277_06053 B277_06053 dapF dapF B277_06373 B277_06373 asd asd B277_06508 B277_06508 B277_06593 B277_06593 B277_06598 B277_06598 B277_06709 B277_06709 B277_06724 B277_06724 B277_06729 B277_06729 B277_06744 B277_06744 B277_06759 B277_06759 B277_06784 B277_06784 fumC fumC B277_06874 B277_06874 B277_06889 B277_06889 B277_06894 B277_06894 B277_06929 B277_06929 B277_06959 B277_06959 B277_06964 B277_06964 B277_06974 B277_06974 B277_06984 B277_06984 gnd gnd ectB ectB ectA ectA B277_07406 B277_07406 B277_07426 B277_07426 B277_07548 B277_07548 acs acs B277_07618 B277_07618 B277_07690 B277_07690 B277_07800 B277_07800 B277_07805 B277_07805 B277_07815 B277_07815 B277_07875 B277_07875 B277_07965 B277_07965 B277_08010 B277_08010 glyA glyA B277_08175 B277_08175 scpB scpB B277_08499 B277_08499 B277_08519 B277_08519 B277_08604 B277_08604 B277_08644 B277_08644 B277_08704 B277_08704 B277_08794 B277_08794 B277_08814 B277_08814 gpmA gpmA B277_08974 B277_08974 B277_09177 B277_09177 B277_09222 B277_09222 B277_09287 B277_09287 B277_09397 B277_09397 xerC-2 xerC-2 B277_09497 B277_09497 serB serB B277_09782 B277_09782 B277_09787 B277_09787 B277_09812 B277_09812 B277_09832 B277_09832 tal tal B277_09887 B277_09887 zwf zwf pgl pgl tpiA tpiA pgk pgk gap gap B277_09937 B277_09937 B277_10044 B277_10044 icmF icmF pckG pckG B277_10269 B277_10269 cysK cysK B277_10279 B277_10279 B277_10304 B277_10304 B277_10314 B277_10314 thrB thrB B277_10364 B277_10364 B277_10369 B277_10369 B277_10409 B277_10409 B277_10451 B277_10451 gltX gltX B277_10596 B277_10596 B277_10735 B277_10735 B277_10855 B277_10855 B277_10860 B277_10860 glpX glpX B277_10945 B277_10945 B277_11160 B277_11160 B277_11190 B277_11190 B277_11360 B277_11360 B277_11385 B277_11385 nirD nirD B277_11395 B277_11395 B277_11400 B277_11400 B277_11405 B277_11405 B277_11445 B277_11445 B277_11450 B277_11450 B277_11545 B277_11545 B277_11580 B277_11580 rpe rpe B277_11830 B277_11830 B277_11880 B277_11880 gltD gltD B277_11890 B277_11890 B277_12241 B277_12241 B277_12261 B277_12261 B277_12436 B277_12436 B277_12486 B277_12486 B277_12541 B277_12541 B277_12656 B277_12656 B277_12701 B277_12701 B277_12711 B277_12711 B277_12751 B277_12751 B277_12786 B277_12786 B277_12791 B277_12791 B277_12841 B277_12841 B277_12846 B277_12846 B277_12901 B277_12901 merA merA B277_12984 B277_12984 B277_13044 B277_13044 B277_13129 B277_13129 B277_13139 B277_13139 B277_13164 B277_13164 B277_13174 B277_13174 B277_13189 B277_13189 B277_13324 B277_13324 B277_13329 B277_13329 B277_13494 B277_13494 B277_13569 B277_13569 B277_13574 B277_13574 B277_13784 B277_13784 B277_13804 B277_13804 B277_13834 B277_13834 B277_13839 B277_13839 B277_13869 B277_13869 B277_13904 B277_13904 B277_13909 B277_13909 B277_13949 B277_13949 lpdA lpdA B277_14094 B277_14094 B277_14124 B277_14124 B277_14209 B277_14209 B277_14214 B277_14214 B277_14274 B277_14274 B277_14314 B277_14314 B277_14339 B277_14339 aceE aceE B277_14478 B277_14478 B277_14483 B277_14483 B277_14488 B277_14488 B277_14498 B277_14498 B277_14503 B277_14503 mce mce B277_14513 B277_14513 B277_14648 B277_14648 B277_14658 B277_14658 B277_14718 B277_14718 B277_14748 B277_14748 cobA cobA B277_14883 B277_14883 B277_14913 B277_14913 B277_14948 B277_14948 B277_14953 B277_14953 B277_14963 B277_14963 B277_14968 B277_14968 B277_15013 B277_15013 B277_15018 B277_15018 B277_15159 B277_15159 B277_15184 B277_15184 B277_15189 B277_15189 B277_15214 B277_15214 B277_15239 B277_15239 B277_15284 B277_15284 B277_15494 B277_15494 B277_15499 B277_15499 B277_15504 B277_15504 B277_15832 B277_15832 B277_15842 B277_15842 B277_15847 B277_15847 B277_16089 B277_16089 B277_16104 B277_16104 B277_16292 B277_16292 B277_16302 B277_16302 B277_16307 B277_16307
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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ectCL-ectoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (129 aa)
B277_00055COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (358 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (266 aa)
gltACOG0372 Citrate synthase; Belongs to the citrate synthase family. (427 aa)
B277_00080Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (108 aa)
B277_00265COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (193 aa)
B277_00405COG1064 Zn-dependent alcohol dehydrogenases. (345 aa)
B277_00430Hypothetical protein; COG1073 Hydrolases of the alpha/beta superfamily. (239 aa)
B277_00595COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. (670 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (323 aa)
B277_00825COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (247 aa)
sdhACOG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (636 aa)
B277_00835Succinate dehydrogenase subunit C. (214 aa)
hemLCOG0001 Glutamate-1-semialdehyde aminotransferase. (443 aa)
B277_00855COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (332 aa)
B277_00860uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; COG0007 Uroporphyrinogen-III methylase. (512 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (319 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (424 aa)
B277_00935Xylose isomerase domain-containing protein TIM barrel; COG1082 Sugar phosphate isomerases/epimerases. (276 aa)
B277_00955COG0277 FAD/FMN-containing dehydrogenases. (469 aa)
B277_01129Hypothetical protein; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (458 aa)
B277_01139COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (429 aa)
B277_01149COG2030 Acyl dehydratase. (281 aa)
B277_01184Hypothetical protein; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (449 aa)
B277_01204Mutase; COG0406 Fructose-2,6-bisphosphatase. (238 aa)
B277_01434COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Belongs to the DapA family. (479 aa)
B277_01449COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases). (347 aa)
B277_01464COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (341 aa)
B277_01529D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (400 aa)
gabD2Succinic semialdehyde dehydrogenase; COG1012 NAD-dependent aldehyde dehydrogenases. (530 aa)
B277_01594Hypothetical protein; COG2303 Choline dehydrogenase and related flavoproteins. (596 aa)
B277_01704Cysteine dioxygenase. (167 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)
folD5,10-methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (331 aa)
B277_01839Oxidoreductase; COG2041 Sulfite oxidase and related enzymes. (462 aa)
B277_01994COG3564 Uncharacterized protein conserved in bacteria. (124 aa)
B277_01999COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (507 aa)
B277_02004COG0033 Phosphoglucomutase. (550 aa)
B277_02194COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (413 aa)
B277_02199COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (354 aa)
B277_02204Hypothetical protein; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (456 aa)
B277_02491COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (608 aa)
B277_02496COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (736 aa)
B277_02536Carbon monoxide dehydrogenase subunit G. (247 aa)
B277_02541COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs. (283 aa)
B277_02546Xanthine dehydrogenase, molybdenum binding subunit apoprotein; COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs. (838 aa)
B277_025512Fe-2S iron-sulfur cluster binding domain-containing protein; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. (161 aa)
B277_02586COG0076 Glutamate decarboxylase and related PLP-dependent proteins. (452 aa)
B277_02656Hypothetical protein. (220 aa)
B277_02696COG2188 Transcriptional regulators. (245 aa)
B277_02788COG0412 Dienelactone hydrolase and related enzymes. (254 aa)
B277_02798COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (293 aa)
B277_02833COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. (330 aa)
B277_03158Amidase; COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases. (568 aa)
B277_03178COG2902 NAD-specific glutamate dehydrogenase. (1606 aa)
B277_03273Secreted protein; COG1073 Hydrolases of the alpha/beta superfamily. (381 aa)
B277_03425COG2826 Transposase and inactivated derivatives, IS30 family. (292 aa)
B277_03520(2Fe-2S)-binding domain-containing protein; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. (166 aa)
B277_03525COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs. (329 aa)
B277_03540Hypothetical protein. (150 aa)
B277_03545COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. (301 aa)
B277_03650Polyketide cyclase/dehydrase. (145 aa)
B277_03665COG3508 Homogentisate 1,2-dioxygenase. (403 aa)
B277_03675Fumarylacetoacetase; COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (392 aa)
B277_04040COG0777 Acetyl-CoA carboxylase beta subunit. (356 aa)
B277_04045COG0825 Acetyl-CoA carboxylase alpha subunit. (285 aa)
B277_04160Hypothetical protein. (143 aa)
B277_04165Hypothetical protein; COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain. (105 aa)
B277_04170Peroxidase. (65 aa)
B277_04185Phosphoglycerate mutase; COG0406 Fructose-2,6-bisphosphatase; Belongs to the phosphoglycerate mutase family. (224 aa)
B277_04227COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (378 aa)
B277_042323-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase. (690 aa)
acnACOG1048 Aconitase A. (933 aa)
B277_04347Type I phosphodiesterase/nucleotide pyrophosphatase; COG1524 Uncharacterized proteins of the AP superfamily. (383 aa)
B277_04357CoA-binding protein; COG1042 Acyl-CoA synthetase (NDP forming). (636 aa)
B277_046372-oxoglutarate synthase; COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. (366 aa)
B277_04642Pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit. (623 aa)
B277_04707Isoquinoline 1-oxidoreductase subunit alpha; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. (158 aa)
B277_04712Isoquinoline 1-oxidoreductase subunit beta; COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs. (772 aa)
B277_04752Dienelactone hydrolase. (199 aa)
B277_04757COG1024 Enoyl-CoA hydratase/carnithine racemase. (159 aa)
B277_05094COG5285 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin. (345 aa)
B277_05099Short chain dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (256 aa)
B277_05104Oxidoreductase domain-containing protein; COG0673 Predicted dehydrogenases and related proteins. (341 aa)
B277_05109Ferredoxin reductase MocF; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases. (407 aa)
B277_05124Inositol 2-dehydrogenase; COG0673 Predicted dehydrogenases and related proteins. (337 aa)
B277_05144IolD protein; COG3962 Acetolactate synthase. (736 aa)
iolBHypothetical protein; COG3718 Uncharacterized enzyme involved in inositol metabolism. (322 aa)
iolC5-dehydro-2-deoxygluconokinase; COG0524 Sugar kinases, ribokinase family. (320 aa)
B277_05159Myo-inosose-2 dehydratase; COG1082 Sugar phosphate isomerases/epimerases. (308 aa)
B277_05164Inositol 2-dehydrogenase; COG0673 Predicted dehydrogenases and related proteins. (338 aa)
B277_05169COG2188 Transcriptional regulators. (250 aa)
B277_05264Pyruvate carboxylase; COG0511 Biotin carboxyl carrier protein. (72 aa)
B277_05354COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (297 aa)
B277_05381COG0174 Glutamine synthetase. (88 aa)
B277_05386COG0174 Glutamine synthetase. (268 aa)
argDCOG4992 Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (402 aa)
B277_05693Hypothetical protein. (200 aa)
B277_05698COG0698 Ribose 5-phosphate isomerase RpiB. (155 aa)
B277_05823Hypothetical protein; COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain. (112 aa)
B277_05908COG2879 Uncharacterized small protein. (119 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (240 aa)
B277_05953COG1024 Enoyl-CoA hydratase/carnithine racemase. (240 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (282 aa)
B277_06053Carboxymuconolactone decarboxylase family protein. (178 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (289 aa)
B277_06373COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases). (324 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (345 aa)
B277_06508Monooxygenase; COG2072 Predicted flavoprotein involved in K+ transport. (417 aa)
B277_06593COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (248 aa)
B277_06598COG2897 Rhodanese-related sulfurtransferase. (273 aa)
B277_06709Putative bifunctional P-450/NADPH-P450 reductase; COG2124 Cytochrome P450. (488 aa)
B277_06724COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (521 aa)
B277_06729COG0656 Aldo/keto reductases, related to diketogulonate reductase. (276 aa)
B277_06744Putative FAD-dependent monooxygenase; COG2072 Predicted flavoprotein involved in K+ transport. (537 aa)
B277_06759COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (271 aa)
B277_06784Hydrolase; COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold. (500 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa)
B277_06874Formate dehydrogenase subunit alpha; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing. (190 aa)
B277_06889Formate dehydrogenase subunit beta; COG0437 Fe-S-cluster-containing hydrogenase components 1. (379 aa)
B277_06894COG3301 Formate-dependent nitrite reductase, membrane component. (381 aa)
B277_06929COG1765 Predicted redox protein, regulator of disulfide bond formation. (155 aa)
B277_06959COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (493 aa)
B277_06964COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (400 aa)
B277_06974COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases. (329 aa)
B277_06984COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (405 aa)
gndCOG1023 Predicted 6-phosphogluconate dehydrogenase. (361 aa)
ectBDiaminobutyrate--2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa)
ectADiaminobutyrate acetyltransferase; Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. (168 aa)
B277_07406COG0259 Pyridoxamine-phosphate oxidase. (229 aa)
B277_07426COG4221 Short-chain alcohol dehydrogenase of unknown specificity. (679 aa)
B277_07548Integrase catalytic subunit. (148 aa)
acsacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (643 aa)
B277_07618COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (263 aa)
B277_07690COG2826 Transposase and inactivated derivatives, IS30 family. (70 aa)
B277_07800Morphological differentiation-associated protein; COG0560 Phosphoserine phosphatase. (485 aa)
B277_07805COG2186 Transcriptional regulators. (236 aa)
B277_07815Putative gluconokinase; COG3265 Gluconate kinase. (174 aa)
B277_07875Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (344 aa)
B277_07965Iron-binding zinc finger protein, CDGSH type. (75 aa)
B277_08010COG2303 Choline dehydrogenase and related flavoproteins. (544 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa)
B277_08175Hypothetical protein; COG1145 Ferredoxin. (98 aa)
scpBCondensin subunit ScpB; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (216 aa)
B277_08499Hypothetical protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold. (278 aa)
B277_08519COG1064 Zn-dependent alcohol dehydrogenases. (349 aa)
B277_08604COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (427 aa)
B277_08644COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases). (336 aa)
B277_08704OsmC family protein; COG1764 Predicted redox protein, regulator of disulfide bond formation. (140 aa)
B277_08794Mycothiol-dependent formaldehyde dehydrogenase; COG1062 Zn-dependent alcohol dehydrogenases, class III. (362 aa)
B277_08814FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COG2072 Predicted flavoprotein involved in K+ transport. (354 aa)
gpmA2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (244 aa)
B277_08974COG1024 Enoyl-CoA hydratase/carnithine racemase. (240 aa)
B277_09177Biotin carboxyl carrier protein; COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit; biotin carboxylase. (588 aa)
B277_09222COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (520 aa)
B277_09287COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (546 aa)
B277_09397COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (266 aa)
xerC-2Tyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (314 aa)
B277_09497Succinyldiaminopimelate aminotransferase apoenzyme; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (382 aa)
serBCOG0560 Phosphoserine phosphatase. (241 aa)
B277_09782Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (246 aa)
B277_09787Putative nitrite/sulfite reductase; COG0155 Sulfite reductase, beta subunit (hemoprotein); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (549 aa)
B277_09812Hypothetical protein; COG2151 Predicted metal-sulfur cluster biosynthetic enzyme. (109 aa)
B277_09832COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases. (111 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (379 aa)
B277_09887COG0166 Glucose-6-phosphate isomerase; Belongs to the GPI family. (538 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (514 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (243 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (263 aa)
pgkCOG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (402 aa)
gapCOG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
B277_09937Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (316 aa)
B277_10044Putative FAD-dependent oxidoreductase; COG0579 Predicted dehydrogenase. (309 aa)
icmFmethylmalonyl-CoA mutase large subunit; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1083 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (612 aa)
B277_10269COG1045 Serine acetyltransferase. (199 aa)
cysKCOG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (308 aa)
B277_10279Hypothetical protein; COG0247 Fe-S oxidoreductase. (1222 aa)
B277_103043-hydroxyisobutyryl-CoA hydrolase; COG1024 Enoyl-CoA hydratase/carnithine racemase. (343 aa)
B277_10314Amidase; COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases; Belongs to the amidase family. (493 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
B277_10364Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (366 aa)
B277_10369COG0460 Homoserine dehydrogenase. (392 aa)
B277_10409COG0376 Catalase (peroxidase I). (523 aa)
B277_10451COG1254 Acylphosphatases. (96 aa)
gltXglutamyl-tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (516 aa)
B277_10596COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (258 aa)
B277_10735COG2259 Predicted membrane protein. (171 aa)
B277_10855Sulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (428 aa)
B277_10860Sulfate adenylyltransferase subunit 2; COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes. (304 aa)
glpXCOG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins. (338 aa)
B277_10945COG3631 Ketosteroid isomerase-related protein. (117 aa)
B277_11160COG0174 Glutamine synthetase. (259 aa)
B277_11190ROK family protein; COG1940 Transcriptional regulator/sugar kinase. (251 aa)
B277_11360COG1587 Uroporphyrinogen-III synthase. (280 aa)
B277_11385COG1587 Uroporphyrinogen-III synthase. (369 aa)
nirDCOG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases. (130 aa)
B277_11395Nitrite reductase (NAD(P)H) large subunit; COG1251 NAD(P)H-nitrite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (863 aa)
B277_11400COG1251 NAD(P)H-nitrite reductase. (512 aa)
B277_11405Molybdopterin oxidoreductase; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (653 aa)
B277_11445Peptidase S66 family protein; COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF. (345 aa)
B277_11450COG4757 Predicted alpha/beta hydrolase. (284 aa)
B277_11545COG1011 Predicted hydrolase (HAD superfamily). (212 aa)
B277_11580Hypothetical protein. (79 aa)
rpeCOG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (218 aa)
B277_11830Hypothetical protein. (212 aa)
B277_11880Glutamate synthase (NADH) large subunit; COG0067 Glutamate synthase domain 1. (1521 aa)
gltDGlutamate synthase (NADH) small subunit; COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. (485 aa)
B277_11890COG0469 Pyruvate kinase; overlaps another CDS with the same product name. (526 aa)
B277_12241Putative polyketide cyclase/dehydrase. (157 aa)
B277_12261Pyruvate phosphate dikinase; COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (899 aa)
B277_12436Hypothetical protein; COG2068 Uncharacterized MobA-related protein. (186 aa)
B277_12486HpcH/HpaI aldolase; COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. (356 aa)
B277_12541Phosphoglycerate mutase; COG0406 Fructose-2,6-bisphosphatase; Belongs to the phosphoglycerate mutase family. (203 aa)
B277_12656D-isomer specific 2-hydroxyacid dehydrogenase; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases. (308 aa)
B277_12701COG1024 Enoyl-CoA hydratase/carnithine racemase. (114 aa)
B277_12711COG1011 Predicted hydrolase (HAD superfamily). (222 aa)
B277_12751Putative enoyl-CoA hydratase 1; COG2030 Acyl dehydratase (Nodulation protein) (N-related protein). (156 aa)
B277_12786COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
B277_12791Carbamoyl-phosphate synthase L chain ATP-binding protein; COG0439 Biotin carboxylase; overlaps another CDS with the same product name. (748 aa)
B277_12841Hypothetical protein; COG2030 Acyl dehydratase; Belongs to the UPF0336 family. (148 aa)
B277_12846MaoC domain-containing protein dehydratase; COG2030 Acyl dehydratase. (143 aa)
B277_12901Integrase catalytic subunit; COG2826 Transposase and inactivated derivatives, IS30 family. (63 aa)
merAMercuric reductase; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (466 aa)
B277_12984COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold. (264 aa)
B277_13044Hypothetical protein. (143 aa)
B277_13129FAD-binding dehydrogenase; COG3573 Predicted oxidoreductase. (547 aa)
B277_13139COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (484 aa)
B277_13164COG0372 Citrate synthase; Belongs to the citrate synthase family. (368 aa)
B277_13174Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (373 aa)
B277_13189COG2252 Permeases. (391 aa)
B277_13324Mycothione reductase; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (474 aa)
B277_13329Phosphosugar isomerase. (392 aa)
B277_13494Aromatic amino acid beta-eliminating lyase/threonine aldolase; COG2008 Threonine aldolase. (359 aa)
B277_13569Osmc family protein; COG1765 Predicted redox protein, regulator of disulfide bond formation. (151 aa)
B277_13574Monooxygenase; COG2072 Predicted flavoprotein involved in K+ transport. (354 aa)
B277_137842,4-dienoyl-CoA reductase (NADPH); COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. (76 aa)
B277_13804NADH:flavin oxidoreductase/NADH oxidase. (97 aa)
B277_13834Succinate CoA transferase; COG0427 Acetyl-CoA hydrolase. (504 aa)
B277_13839NAD dependent epimerase/dehydratase family protein; COG0451 Nucleoside-diphosphate-sugar epimerases. (258 aa)
B277_13869COG0174 Glutamine synthetase. (539 aa)
B277_13904Hypothetical protein; COG0323 DNA mismatch repair enzyme (predicted ATPase). (425 aa)
B277_13909Hypothetical protein. (358 aa)
B277_13949COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (616 aa)
lpdACOG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (462 aa)
B277_14094Aromatic ring-opening dioxygenase catalytic subunit. (264 aa)
B277_14124Integrase catalytic subunit. (88 aa)
B277_14209COG2252 Permeases. (49 aa)
B277_14214COG2252 Permeases. (89 aa)
B277_14274Transposase of ISAar43, IS3 family, IS407 group, orfB; COG2801 Transposase and inactivated derivatives. (168 aa)
B277_14314Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein; COG3467 Predicted flavin-nucleotide-binding protein. (141 aa)
B277_14339COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (489 aa)
aceEPyruvate dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (930 aa)
B277_14478Iron-sulfur cluster binding protein; COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain. (494 aa)
B277_14483COG0247 Fe-S oxidoreductase. (240 aa)
B277_14488COG1250 3-hydroxyacyl-CoA dehydrogenase. (286 aa)
B277_14498COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases; overlaps another CDS with the same product name. (241 aa)
B277_14503COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases; overlaps another CDS with the same product name. (308 aa)
mcemethylmalonyl-CoA epimerase; COG0346 Lactoylglutathione lyase and related lyases. (143 aa)
B277_14513COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
B277_14648Twin-arginine translocation pathway signal; COG3485 Protocatechuate 3,4-dioxygenase beta subunit. (325 aa)
B277_14658Putative oxidoreductase; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (469 aa)
B277_14718COG0656 Aldo/keto reductases, related to diketogulonate reductase. (161 aa)
B277_14748COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases. (345 aa)
cobAuroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase. (254 aa)
B277_14883Hypothetical protein. (233 aa)
B277_14913Dehydratase; COG2030 Acyl dehydratase. (350 aa)
B277_14948COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (245 aa)
B277_14953Pyrophosphate--fructose-6-phosphate 1-phosphotransferase; COG0205 6-phosphofructokinase. (402 aa)
B277_14963COG0136 Aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (359 aa)
B277_14968COG0527 Aspartokinases; Belongs to the aspartokinase family. (424 aa)
B277_15013NAD-binding protein 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (724 aa)
B277_15018COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
B277_15159Hypothetical protein; COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (299 aa)
B277_15184COG1024 Enoyl-CoA hydratase/carnithine racemase. (249 aa)
B277_15189COG0183 Acetyl-CoA acetyltransferase. (110 aa)
B277_15214Hypothetical protein; COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins. (170 aa)
B277_15239Putative lysine decarboxylase; COG0076 Glutamate decarboxylase and related PLP-dependent proteins. (498 aa)
B277_15284Hypothetical protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold. (141 aa)
B277_15494Sugar kinase; COG1940 Transcriptional regulator/sugar kinase. (189 aa)
B277_15499Glucokinase, rok family protein; COG1940 Transcriptional regulator/sugar kinase. (283 aa)
B277_15504Glucokinase; COG1940 Transcriptional regulator/sugar kinase. (322 aa)
B277_15832Aminoglycoside phosphotransferase. (271 aa)
B277_15842LPPG:FO 2-phospho-L-lactate transferase; COG0391 Uncharacterized conserved protein; overlaps another CDS with the same product name. (143 aa)
B277_15847LPPG:FO 2-phospho-L-lactate transferase; COG0391 Uncharacterized conserved protein; overlaps another CDS with the same product name. (187 aa)
B277_16089COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (733 aa)
B277_16104COG1250 3-hydroxyacyl-CoA dehydrogenase. (402 aa)
B277_16292IS30 family transposase; COG2826 Transposase and inactivated derivatives, IS30 family. (161 aa)
B277_16302COG2826 Transposase and inactivated derivatives, IS30 family. (113 aa)
B277_16307Integrase catalytic subunit; COG2826 Transposase and inactivated derivatives, IS30 family. (355 aa)
Your Current Organism:
Janibacter hoylei
NCBI taxonomy Id: 1210046
Other names: J. hoylei PVAS-1, Janibacter hoylei DSM 21601, Janibacter hoylei MTCC 8307, Janibacter hoylei PVAS-1, Janibacter hoylei str. PVAS-1, Janibacter hoylei strain PVAS-1, Janibacter sp. PVAS-1
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